Ultraviolet irradiation improves the hydrophilicity and osteo-conduction of hydroxyapatite
Background: Treating a titanium or titanium alloy implant with ultraviolet (UV) light is known to improve its associated cell growth and osseointegration. However, little is known about the effect of UV irradiation on hydroxyapatite (HA), which is also used frequently in orthopaedic and dental surgery. Here we examined the effect of UV irradiation on the hydrophilicity of HA, and on its osteoconduction ability in rats.
Methods: HA implants of low and high porosity were treated with UV light, and photofunctionalisation was assessed by the contact angle of a water drop on the surface. HA implants were also inserted into rat femurs, and the rats were killed two or four weeks later. The bone volume and bone area ratio were calculated from microcomputed tomography and histological data.
Results: The contact angle of a water drop on HA implants of both porosities was significantly reduced after UV irradiation. In the rat femurs, there was no significant difference in the bone volume between the UV light-treated and control implants at two or four weeks. The bone area ratio for the UV light-treated versus control implants was significantly increased at two weeks, but there was no significant difference at four weeks.
Conclusions: The surface of UV-irradiated HA disks was hydrophilic, in contrast to that of non-irradiated HA disks. Photofunctionalisation accelerated the increase in the bone area ratio in the early healing stage. This technology can be applied to surgical cases requiring the early fusion of bone and HA.
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Posted 15 Jun, 2020
On 18 Sep, 2020
On 07 Sep, 2020
On 12 Jun, 2020
On 11 Jun, 2020
On 11 Jun, 2020
On 11 May, 2020
Received 02 May, 2020
Received 02 May, 2020
On 01 May, 2020
On 29 Apr, 2020
On 28 Apr, 2020
Invitations sent on 28 Apr, 2020
On 28 Apr, 2020
On 28 Apr, 2020
On 27 Apr, 2020
On 17 Apr, 2020
On 16 Apr, 2020
Ultraviolet irradiation improves the hydrophilicity and osteo-conduction of hydroxyapatite
Posted 15 Jun, 2020
On 18 Sep, 2020
On 07 Sep, 2020
On 12 Jun, 2020
On 11 Jun, 2020
On 11 Jun, 2020
On 11 May, 2020
Received 02 May, 2020
Received 02 May, 2020
On 01 May, 2020
On 29 Apr, 2020
On 28 Apr, 2020
Invitations sent on 28 Apr, 2020
On 28 Apr, 2020
On 28 Apr, 2020
On 27 Apr, 2020
On 17 Apr, 2020
On 16 Apr, 2020
Background: Treating a titanium or titanium alloy implant with ultraviolet (UV) light is known to improve its associated cell growth and osseointegration. However, little is known about the effect of UV irradiation on hydroxyapatite (HA), which is also used frequently in orthopaedic and dental surgery. Here we examined the effect of UV irradiation on the hydrophilicity of HA, and on its osteoconduction ability in rats.
Methods: HA implants of low and high porosity were treated with UV light, and photofunctionalisation was assessed by the contact angle of a water drop on the surface. HA implants were also inserted into rat femurs, and the rats were killed two or four weeks later. The bone volume and bone area ratio were calculated from microcomputed tomography and histological data.
Results: The contact angle of a water drop on HA implants of both porosities was significantly reduced after UV irradiation. In the rat femurs, there was no significant difference in the bone volume between the UV light-treated and control implants at two or four weeks. The bone area ratio for the UV light-treated versus control implants was significantly increased at two weeks, but there was no significant difference at four weeks.
Conclusions: The surface of UV-irradiated HA disks was hydrophilic, in contrast to that of non-irradiated HA disks. Photofunctionalisation accelerated the increase in the bone area ratio in the early healing stage. This technology can be applied to surgical cases requiring the early fusion of bone and HA.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7