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Research Article
Berna Eriten
Malatya Education and Research Hospital
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objectives: We aimed the relationship between with selected prognostic factors of MM, 1) C-KIT (CD117), which related to MM pathogenesis, 2) Ki-67, which is the determinant of cell kinetics, 3) MMP-2, which degradation of the basement membrane and extracellular matrix required for cell migration, invasion and metastasis in melanogenesis, 4) bcl-2, which reduces the apoptotic response to cytotoxic chemotherapy and 5) MT’s whose overexpression shows resistance to anticancer drugs and radiotherapy and thus poor prognosis.
Material and Methods: In this study, 30 skin and 15 non-skin MMM cases diagnosed between January 01, 2000 and June 01, 2011 in SCU-TF Medical Pathology Department were examined. C-Kit, MMP-2, Ki-67, bcl-2 and MT markers were applied to these cases.
Results: When comparing the skin and non-skin groups, the difference between Ki-67 and MMP-2 expressions was found to be statistically significant, but no significant difference was found in staining with c-Kit, MT and bcl-2. It was thought that high MMP-2, C-KIT, bcl-2 expressions and high Ki-67 index as well as loss of MT expression might be associated with poor prognosis. Despite the high level of KIT immunostaining in melanomas, this parameter does not appear to be a good predictor of the presence of molecular mutations. Mutations that activate KIT should be considered a rare event in this tumor.
Keywords
bcl-2, c-KIT, Kellgren-Lawrence Staging System (KLSS), Ki-67, Malignant Melanoma, Metallothionein, MMP-2, Prognostic Factors
No competing interests reported.
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This is a preprint. It has not completed peer review.
Research Article
Berna Eriten
Malatya Education and Research Hospital
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 17 Mar, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objectives: We aimed the relationship between with selected prognostic factors of MM, 1) C-KIT (CD117), which related to MM pathogenesis, 2) Ki-67, which is the determinant of cell kinetics, 3) MMP-2, which degradation of the basement membrane and extracellular matrix required for cell migration, invasion and metastasis in melanogenesis, 4) bcl-2, which reduces the apoptotic response to cytotoxic chemotherapy and 5) MT’s whose overexpression shows resistance to anticancer drugs and radiotherapy and thus poor prognosis.
Material and Methods: In this study, 30 skin and 15 non-skin MMM cases diagnosed between January 01, 2000 and June 01, 2011 in SCU-TF Medical Pathology Department were examined. C-Kit, MMP-2, Ki-67, bcl-2 and MT markers were applied to these cases.
Results: When comparing the skin and non-skin groups, the difference between Ki-67 and MMP-2 expressions was found to be statistically significant, but no significant difference was found in staining with c-Kit, MT and bcl-2. It was thought that high MMP-2, C-KIT, bcl-2 expressions and high Ki-67 index as well as loss of MT expression might be associated with poor prognosis. Despite the high level of KIT immunostaining in melanomas, this parameter does not appear to be a good predictor of the presence of molecular mutations. Mutations that activate KIT should be considered a rare event in this tumor.
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