Abd El-Hameed, A. M.; Eskandrani, A. A.; Elroby, F. A. (2020): Assessment of the ameliorative effect of Hypericum perforatum on olanzapine-induced hepatic oxidative stress and metabolic abnormalities in experimental male albino rats. Journal of Taibah University for Science, v. 14, n. 1, p. 1496-1502, ISSN 1658-3655.
Abd El-Hameed, A. M.; Mahmoud, H. S. (2020): Cypermethrin induced apoptosis and testicular toxicity by upregulation of p53 in the brain and testis of male rats is alleviated by Sesame oil. Journal of Taibah University for Science, v. 14, n. 1, p. 1342-1349, ISSN 1658-3655.
Abdel-Reheim, E. S. (2009): Physiological and biochemical studies on the melatonin effect on the fertility of epileptic rats. J. Egyp. Ger. Soci. Zool, v. 58, p. 1-25,
Adelman, J. P.; Maylie, J.; Sah, P. (2012): Small-conductance Ca2+-activated K+ channels: form and function. Annual review of physiology, v. 74, p. 245-269, ISSN 0066-4278.
Aust, W.; Wichmann, G.; Dietz, A. (2010): Therapy control of specific hymenoptera venom allergy. Laryngo-rhino-otologie, v. 89, n. 12, p. 725-728, ISSN 0935-8943.
Baek, H.; Lee, C.-j.; Choi, D. B.; Kim, N.-s.; Kim, Y.-S.; Ye, Y. J. et al. (2018): Bee venom phospholipase A2 ameliorates Alzheimer’s disease pathology in Aβ vaccination treatment without inducing neuro-inflammation in a 3xTg-AD mouse model. SCIentIfIC RepoRtS, v. 8, n. 1, p. 1-11, ISSN 2045-2322.
Beghi, E.; Giussani, G.; Nichols, E.; Abd-Allah, F.; Abdela, J.; Abdelalim, A. et al. (2019): Global, regional, and national burden of epilepsy, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet Neurology, v. 18, n. 4, p. 357-375, ISSN 1474-4422.
Bhat, R.; Axtell, R.; Mitra, A.; Miranda, M.; Lock, C.; Tsien, R. W. et al. (2010): Inhibitory role for GABA in autoimmune inflammation. Proceedings of the National Academy of Sciences, v. 107, n. 6, p. 2580-2585, Disponível em: < https://www.pnas.org/content/pnas/107/6/2580.full.pdf >.
Bradford, M. M. (1976): A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical biochemistry, v. 72, n. 1-2, p. 248-254, ISSN 0003-2697.
Cacheaux, L. P.; Ivens, S.; David, Y.; Lakhter, A. J.; Bar-Klein, G.; Shapira, M. et al. (2009): Transcriptome profiling reveals TGF-β signaling involvement in epileptogenesis. Journal of Neuroscience, v. 29, n. 28, p. 8927-8935, ISSN 0270-6474.
Castilla‐Guerra, L.; Fernández‐Moreno, M. d. C.; López‐Chozas, J. M.; Fernández‐Bolaños, R. (2006): Electrolytes disturbances and seizures. Epilepsia, v. 47, n. 12, p. 1990-1998, ISSN 0013-9580.
Chen, J.; Guan, S.-M. (2017): Bee Venom and Pain, . Toxins and Drug Discovery, Toxinology v. P. Gopalakrishnakone et al. (eds.), p. 253-295. DOI 10.1007/978-94-007-6452-1_1,
Chung, E. S.; Kim, H.; Lee, G.; Park, S.; Kim, H.; Bae, H. (2012): Neuro-protective effects of bee venom by suppression of neuroinflammatory responses in a mouse model of Parkinson’s disease: role of regulatory T cells. Brain, behavior, and immunity, v. 26, n. 8, p. 1322-1330, ISSN 0889-1591.
Cipollini, V.; Anrather, J.; Orzi, F.; Iadecola, C. (2019): Th17 and Cognitive Impairment: Possible Mechanisms of Action. Frontiers in Neuroanatomy, v. 13, n. 95, ISSN 1662-5129. Disponível em: < https://www.frontiersin.org/article/10.3389/fnana.2019.00095 >.
Clynen, E.; Swijsen, A.; Raijmakers, M.; Hoogland, G.; Rigo, J.-M. (2014): Neuropeptides as targets for the development of anticonvulsant drugs. Molecular neurobiology, v. 50, n. 2, p. 626-646, ISSN 0893-7648.
Cruciani, R. A.; Barker, J. L.; Zasloff, M.; Chen, H.-C.; Colamonici, O. (1991): Antibiotic magainins exert cytolytic activity against transformed cell lines through channel formation. Proceedings of the National Academy of Sciences, v. 88, n. 9, p. 3792-3796, ISSN 0027-8424.
De Simoni, M. G.; Perego, C.; Ravizza, T.; Moneta, D.; Conti, M.; Marchesi, F. et al. (2000): Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus. European Journal of Neuroscience, v. 12, n. 7, p. 2623-2633, ISSN 0953-816X.
Dolga, A. M.; Culmsee, C. (2012): Protective roles for potassium SK/KCa2 channels in microglia and neurons. Frontiers in Pharmacology, v. 3, p. 196, ISSN 1663-9812.
Du, Y.-R.; Xiao, Y.; Lu, Z.-M.; Ding, J.; Xie, F.; Fu, H. et al. (2011): Melittin activates TRPV1 receptors in primary nociceptive sensory neurons via the phospholipase A2 cascade pathways. Biochemical and biophysical research communications, v. 408, n. 1, p. 32-37, ISSN 0006-291X.
Engelhardt, B.; Ransohoff, R. M. (2012): Capture, crawl, cross: the T cell code to breach the blood–brain barriers. Trends in immunology, v. 33, n. 12, p. 579-589, ISSN 1471-4906.
Faber, E. L.; Sah, P. (2007): Functions of SK channels in central neurons. Proc. Austral. Physiol. Soc, v. 38, p. 25-34,
Farrant, M.; Kaila, K. (2007): The cellular, molecular and ionic basis of GABAA receptor signalling. Progress in brain research, v. 160, p. 59-87, ISSN 0079-6123.
Gu, H.; Han, S. M.; Park, K.-K. (2020): Therapeutic effects of apamin as a bee venom component for non-neoplastic disease. Toxins, v. 12, n. 3, p. 195,
Hossen, M. S.; Gan, S. H.; Khalil, M. I. (2017): Melittin, a Potential Natural Toxin of Crude Bee Venom: Probable Future Arsenal in the Treatment of Diabetes Mellitus. Journal of Chemistry, v. 2017, p. 4035626, ISSN 2090-9063. Disponível em: < https://doi.org/10.1155/2017/4035626 >.
Khalil, W. K.; Assaf, N.; ElShebiney, S. A.; Salem, N. A. (2015): Neuroprotective effects of bee venom acupuncture therapy against rotenone-induced oxidative stress and apoptosis. Neurochemistry international, v. 80, p. 79-86, ISSN 0197-0186.
Kim, C. (1997): Potentiating health and the crisis of the immune system. Chapter 24; apitherapy (Bee Venom Therapy) literature review. 'Apitherapy Bee Venom Therapy.”: Mizrahi et al., ed. Plenum Press, New York, 1997, pp. 243-269.
Kim, H.; Hong, J. Y.; Jeon, W.-J.; Baek, S. H.; Ha, I.-H. (2020): Bee venom melittin protects against cisplatin-induced acute kidney injury in mice via the regulation of M2 macrophage activation. Toxins, v. 12, n. 9, p. 574,
Kim, S.-J.; Park, J.-H.; Kim, K.-H.; Lee, W.-R.; An, H.-J.; Min, B.-K. et al. (2012): Apamin inhibits THP-1-derived macrophage apoptosis via mitochondria-related apoptotic pathway. Experimental and molecular pathology, v. 93, n. 1, p. 129-134, ISSN 0014-4800.
Kim, W.-H.; An, H.-J.; Kim, J.-Y.; Gwon, M.-G.; Gu, H.; Lee, S.-J. et al. (2017): Apamin inhibits TNF-α-and IFN-γ-induced inflammatory cytokines and chemokines via suppressions of NF-κB signaling pathway and STAT in human keratinocytes. Pharmacological Reports, v. 69, n. 5, p. 1030-1035, ISSN 2299-5684.
Kobow, K.; Auvin, S.; Jensen, F.; Löscher, W.; Mody, I.; Potschka, H. et al. (2012): Finding a better drug for epilepsy: antiepileptogenesis targets. Epilepsia, v. 53, n. 11, p. 1868-1876, ISSN 0013-9580.
Koyama, N.; Hirata, K.; Hori, K.; Dan, K.; Yokota, T. (2000): Computer-assisted infrared thermographic study of axon reflex induced by intradermal melittin. PAIN®, v. 84, n. 2-3, p. 133-139, ISSN 0304-3959.
Krell, R. (1996): Value-added products from beekeeping. Food & Agriculture Org., ISBN 9251038198.
Krishna, M.; Ewan, P.; Diwakar, L.; Durham, S.; Frew, A.; Leech, S. et al. (2011): Diagnosis and management of hymenoptera venom allergy: British Society for Allergy and Clinical Immunology (BSACI) guidelines. Clinical & Experimental Allergy, v. 41, n. 9, p. 1201-1220, ISSN 0954-7894.
Kwon, Y. B.; Kim, H. W.; Ham, T. W.; Yoon, S. Y.; Roh, D. H.; Han, H. J. et al. (2003): The anti‐inflammatory effect of bee venom stimulation in a mouse air pouch model is mediated by adrenal medullary activity. Journal of neuroendocrinology, v. 15, n. 1, p. 93-96, ISSN 0953-8194.
Lai, H. C.; Jan, L. Y. (2006): The distribution and targeting of neuronal voltage-gated ion channels. Nature Reviews Neuroscience, v. 7, n. 7, p. 548-562, ISSN 1471-0048. Disponível em: < https://doi.org/10.1038/nrn1938 >.
Lambe, E. K.; Aghajanian, G. K. (2001): The role of Kv1. 2-containing potassium channels in serotonin-induced glutamate release from thalamocortical terminals in rat frontal cortex. Journal of Neuroscience, v. 21, n. 24, p. 9955-9963, ISSN 0270-6474.
Lee, G.; Bae, H. (2016): Anti-inflammatory applications of melittin, a major component of bee venom: Detailed mechanism of action and adverse effects. Molecules, v. 21, n. 5, p. 616,
Lorincz, A.; Nusser, Z. (2010): Molecular Identity of Dendritic Voltage-Gated Sodium Channels. Science, v. 328, n. 5980, p. 906-909, Disponível em: < https://science.sciencemag.org/content/sci/328/5980/906.full.pdf >.
Löscher, W.; Brandt, C. (2010): Prevention or modification of epileptogenesis after brain insults: experimental approaches and translational research. Pharmacological reviews, v. 62, n. 4, p. 668-700, ISSN 0031-6997.
Luján, R.; Maylie, J.; Adelman, J. P. (2009): New sites of action for GIRK and SK channels. Nature Reviews Neuroscience, v. 10, n. 7, p. 475-480, ISSN 1471-0048.
Magee, J. C.; Johnston, D. (1995): Characterization of single voltage‐gated Na+ and Ca2+ channels in apical dendrites of rat CA1 pyramidal neurons. The Journal of physiology, v. 487, n. 1, p. 67-90, ISSN 0022-3751.
Marx, S. J. (2000): Hyperparathyroid and hypoparathyroid disorders. New England Journal of Medicine v. 343, p. 1863–1875,
Miller, R. J. (2001): Rocking and rolling with Ca2+ channels. Trends in neurosciences, v. 24, n. 8, p. 445-449, ISSN 0166-2236.
Modzelewska, B.; Kostrzewska, A.; Sipowicz, M.; Kleszczewski, T.; Batra, S. (2003): Apamin inhibits NO-induced relaxation of the spontaneous contractile activity of the myometrium from non-pregnant women. Reproductive Biology and Endocrinology, v. 1, n. 1, p. 8, ISSN 1477-7827.
Monge-Fuentes, V.; Gomes, F. M. M.; Campos, G. A. A.; de Castro Silva, J.; Biolchi, A. M.; dos Anjos, L. C. et al. (2015): Neuroactive compounds obtained from arthropod venoms as new therapeutic platforms for the treatment of neurological disorders. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 21, n. 1, p. 1-9, ISSN 1678-9199.
Mrowka, M.; Knabe, S.; Klinge, H.; Oden, P.; Rosenow, F. (2004): Hypocalcemic generalized seizures as manifestation of iatrogenic hypoparathyroidism months to years after thyroid surgery. . Epileptic Disorders, v. 6, p. 85-87,
Nair, X.; Nettleton, D.; Clever, D.; Tramposch, K.; Ghosh, S.; Franson, R. (1993): Swine as a model of skin inflammation. Inflammation, v. 17, n. 2, p. 205-215, ISSN 0360-3997.
Nawaz, A.; Khan, M. A.; Naz, R.; Zeb, S. (2019): Extraction of venom from honey bee in district swat, Khyber Pakhtunkhwa, Pakistan. International Journal of Zoology Studies, v. 4, n. 6, p. 27-30. www.zoologyjournals.com,
NCBI. (2020): Standardized bee venom preparation. PubChem Patent Summary for US-8691283-B2, : National Center for Biotechnology Information. . Retrieved December 31, 2020
Newton, C. R.; Garcia, H. H. (2012): Epilepsy in poor regions of the world. The Lancet, v. 380, n. 9848, p. 1193-1201, ISSN 0140-6736.
Oguni, H. (2004): Diagnosis and treatment of epilepsy. Epilepsia, v. 45, p. 13-16, ISSN 0013-9580.
Park, J.; Jang, K. M.; Park, K.-K. (2020): Apamin suppresses LPS-induced neuroinflammatory responses by regulating SK CHANNELS and TLR4-mediated signaling pathways. International journal of molecular sciences, v. 21, n. 12, p. 4319,
Park, K. M.; Kim, S. E.; Lee, B. I. (2019): Antiepileptic drug therapy in patients with drug-resistant epilepsy. Journal of Epilepsy Research, v. 9, n. 1, p. 14,
Reyes-García, M. G.; Hernández-Hernández, F.; Hernández-Téllez, B.; García-Tamayo, F. (2007): GABA (A) receptor subunits RNA expression in mice peritoneal macrophages modulate their IL-6/IL-12 production. Journal of neuroimmunology, v. 188, n. 1-2, p. 64-68, ISSN 0165-5728.
Riggs, J. E. (2002): Neurologic manifestations of electrolyte disturbances. Neurologic clinics, v. 20, n. 1, p. 227-239, ISSN 0733-8619.
Rozengurt, E.; Gelehrte, T. D.; Legg, A.; Pettican, P. (1981): Melittin stimulates Na entry, Na-K pump activity and DNA synthesis in quiescent cultures of mouse cells. Cell v. 23, n. (3), p. 781-788. doi: 10.1016/0092-8674(81)90442-6.,
Schlichter, L. C.; Kaushal, V.; Moxon-Emre, I.; Sivagnanam, V.; Vincent, C. (2010): The Ca 2+ activated SK3 channel is expressed in microglia in the rat striatum and contributes to microglia-mediated neurotoxicity in vitro. Journal of neuroinflammation, v. 7, n. 1, p. 1-15, ISSN 1742-2094.
Seleem, A. A. (2016): The protective effect of bee venom against verapamil embryotoxicity during prenatal liver and kidney development of mice Mus musculus. The Journal of Basic & Applied Zoology, v. 75, p. 13-27, ISSN 2090-9896.
Shin, M., Cheolsu; McNamara, M., James O. (1994): Mechanism of epilepsy. Annual review of medicine, v. 45, n. 1, p. 379-389, ISSN 0066-4219.
Shin, S. H.; Ye, M. K.; Choi, S. Y.; Park, K. K. (2018): Anti-inflammatory effect of bee venom in an allergic chronic rhinosinusitis mouse model. Molecular medicine reports, v. 17, n. 5, p. 6632-6638, ISSN 1791-2997.
Silva, J.; Monge-Fuentes, V.; Gomes, F.; Lopes, K.; Anjos, L. D.; Campos, G. et al. (2015): Pharmacological alternatives for the treatment of neurodegenerative disorders: Wasp and bee venoms and their components as new neuroactive tools. Toxins, v. 7, n. 8, p. 3179-3209,
Son, D. J.; Lee, J. W.; Lee, Y. H.; Song, H. S.; Lee, C. K.; Hong, J. T. (2007): Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds. Pharmacology & therapeutics, v. 115, n. 2, p. 246-270, ISSN 0163-7258.
Stocker, M. (2004): Ca 2+-activated K+ channels: molecular determinants and function of the SK family. Nature Reviews Neuroscience, v. 5, n. 10, p. 758-770, ISSN 1471-0048.
Stuhlmeier, K. M. (2007): Apis mellifera venom and melittin block neither NF-κB-p50-DNA interactions nor the activation of NF-κB, instead they activate the transcription of proinflammatory genes and the release of reactive oxygen intermediates. The Journal of Immunology, v. 179, n. 1, p. 655-664, ISSN 0022-1767.
Syrbe, S.; Hedrich, U. B.; Riesch, E.; Djémié, T.; Müller, S.; Møller, R. S. et al. (2015): De novo loss-or gain-of-function mutations in KCNA2 cause epileptic encephalopathy. Nature genetics, v. 47, n. 4, p. 393-399, ISSN 1546-1718.
Tian, J.; Chau, C.; Hales, T. G.; Kaufman, D. L. (1999): GABAA receptors mediate inhibition of T cell responses. Journal of neuroimmunology, v. 96, n. 1, p. 21-28, ISSN 0165-5728.
Traub, R. D.; Miles, R.; Jefferys, J. (1993): Synaptic and intrinsic conductances shape picrotoxin‐induced synchronized after‐discharges in the guinea‐pig hippocampal slice. The Journal of Physiology, v. 461, n. 1, p. 525-547, ISSN 0022-3751.
Trimmer, J. S.; Rhodes, K. J. (2004): Localization of voltage-gated ion channels in mammalian brain. Annu. Rev. Physiol., v. 66, p. 477-519, ISSN 0066-4278.
Trumbeckaite, S.; Dauksiene, J.; Bernatoniene, J.; Janulis, V. (2015): Knowledge, attitudes, and usage of apitherapy for disease prevention and treatment among undergraduate pharmacy students in Lithuania. Evidence-Based Complementary and Alternative Medicine, v. 2015, ISSN 1741-427X.
Turski, L.; Ikonomidou, C.; Turski, W. A.; Bortolotto, Z. A.; Cavalheiro, E. A. (1989): Cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: a novel experimental model of intractable epilepsy. Synapse, v. 3, n. 2, p. 154-171, ISSN 0887-4476.
Verma, N.; Karmakar, M.; Singh, K.; Smita, S. (2013): Structural and dynamic insights into S100B protein activity inhibition by melittin for the treatment of epilepsy. Int. J. Comp. App. NSAAILS, v. 1, p. 55-60,
Vezzani, A.; French, J.; Bartfai, T.; Baram, T. Z. (2011): The role of inflammation in epilepsy. Nature reviews neurology, v. 7, n. 1, p. 31, ISSN 1759-4766.
Vezzani, A.; Friedman, A.; Dingledine, R. J. (2013): The role of inflammation in epileptogenesis. Neuropharmacology, v. 69, p. 16-24, ISSN 0028-3908.
Wang, H.; Kunkel, D.; Schwartzkroin, P. A.; Tempel, B. L. (1994): Localization of Kv1. 1 and Kv1. 2, two K channel proteins, to synaptic terminals, somata, and dendrites in the mouse brain. Journal of Neuroscience, v. 14, n. 8, p. 4588-4599, ISSN 0270-6474.
Wehbe, R.; Frangieh, J.; Rima, M.; El Obeid, D.; Sabatier, J.-M.; Fajloun, Z. (2019): Bee venom: Overview of main compounds and bioactivities for therapeutic interests. Molecules, v. 24, n. 16, p. 2997,
Wei, F.; Yan, L.-M.; Su, T.; He, N.; Lin, Z.-J.; Wang, J. et al. (2017): Ion channel genes and epilepsy: functional alteration, pathogenic potential, and mechanism of epilepsy. Neuroscience bulletin, v. 33, n. 4, p. 455-477, ISSN 1673-7067.
WHO. (2020): https://www.who.int/health-topics/epilepsy#tab=tab_1. 2020.
Winocur, G.; Roder, J.; Lobaugh, N. (2001): Learning and memory in S100-β transgenic mice: an analysis of impaired and preserved function. Neurobiology of learning and memory, v. 75, n. 2, p. 230-243, ISSN 1074-7427.