Ethical Approval and Consent to participate
This single-centre observational study was approved by Ethical Committee of the Dr. Kariadi Hospital.
Consent for publication
All authors have consented for the publication.
Avaibility of supporting data
Database of all patients and statistical analaysis are available upon request and authorization from Dr. Kariadi Hospital.
Competing interest
All authors declared no potential conflict of interest with respect to the research, authorship, and/or publication of this article.
Funding: Not applicable
Authors’ contributions:
Budi Setiawan : Conceptualizing and design the study, reviewed data, wrote the first manuscript, analyzed the data and reviewed the final manuscript.
Widi Budianto : Included patients, collected the samples and data, and reviewed the manuscript
Tri Wahyu Sukarnowati : Included patients, collected the samples and data, and reviewed the manuscript.
Daniel Rizky : Assissted with study oversight, collected the data, analyzed and carried out the statistical analysis, and reviewed the manuscript.
Eko Adhi Pangarsa : Supervision the study, critically appraised the manuscript.
Damai Santosa: Supervision the study, critically appraised the manuscript.
Aru Wisaksono Sudoyo : Supervision the study, reviewed data, analyzed the data, critically appraised the manuscript.
Tri Indah Winarni : Supervision the study, reviewed data, analyzed the data, critically appraised the manuscript.
Ignatius Riwanto : Supervision the study, reviewed data, analyzed the data, critically appraised the manuscript.
Rahajuningsih Dharma Setiabudy : Conceptualization design the study, reviewed data, analyzed the data and reviewed the final manuscript, supervision the study, critically appraised the manuscript.
Catharina Suharti : Conceptualization design the study, reviewed data, analyzed the data and reviewed the final manuscript, supervision the study, critically appraised the manuscript.
All authors participated in the interpretation and presentation of the results, then contributed, read and approved the final manuscript hereby submitted for publication
Acknowledgments
Our sincere gratitude to Mika Lumbantobing, M.D., and Suyono, M.D. from the Department of Internal Medicine, Dr. Kariadi Hospital, Diponegoro University, Semarang, Indonesia for their contribution in cancer patient and to all colleagues at dr. Kariadi Hospital who supported us in patient recruitment. We also acknowledge support of the biomolecular laboratory at for providing assistance in ELISA analysis, Gunawan Santosa M.D., Ph.D. for his radiological expertise in performing dupplex ultrasound of the extremities, and Suhartono, M.D., Ph.D. from the Clinical Epidemiology Unit of Diponegoro University for the statistical support. Lastly but not least, the authors would like to thank the participants and their family for contributing by enrolling in the study.
Authors detail:
Budi Setiawan is Hematologist and Medical Oncologist, PhD in Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Diponegoro University/Dr. Kariadi Hospital, Semarang, Indonesia
Widi Budianto is a clinical fellow in Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Diponegoro University/Dr. Kariadi Hospital, Semarang, Indonesia.
Tri Wahyu Sukarnowati is a clinical fellow in Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Diponegoro University/Dr. Kariadi Hospital, Semarang, Indonesia.
Daniel Rizky is Hematologist and Medical Oncologist in Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Diponegoro University/Dr. Kariadi Hospital, Semarang, Indonesia
Eko Adhi Pangarsa is Hematologist and Medical Oncologist, PhD candidate in Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Diponegoro University/Dr. Kariadi Hospital, Semarang, Indonesia
Damai Santosa is Hematologist and Medical Oncologist, PhD, chief of Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Diponegoro University/Dr. Kariadi Hospital, Semarang, Indonesia
Aru Wisaksono Sudoyo is professor of medicine in Internal Medicine Department, Faculty of Medicine, Indonesian University/Cipto Mangunkusumo Hospital, Jakarta, Indonesia
Tri Indah Winarni is professor of medicine in Anatomy Department, Faculty of Medicine, Diponegoro University, Semarang, Indonesia
Ignatius Riwanto is professor of medicine in Surgery Department, Faculty of Medicine Diponegoro University/Dr. Kariadi Hospital, Semarang, Indonesia
Rahajuningsih Dharma Setiabudy is professor of medicine in Clinical Pathology Department, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
Catharina Suharti is professor of medicine in Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Diponegoro University/Dr. Kariadi Hospital, Semarang, Indonesia