This preprint is under consideration at Archives of Gynecology and Obstetrics. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Research Article
Patrick Stelzl
Johannes Kepler Universitat Linz
Corresponding Author
ORCiD: https://orcid.org/0000-0002-5915-7788
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose: Exposure to endocrine disrupting chemicals (EDCs) is ubiquitous in modern civilization and their impact on hormonal regulation in vivid organisms is well established. These substances also seem to play a pivotal role during pregnancy as they might influence birth and pregnancy outcomes, such as fetal birthweight and pregnancy duration.
The objective of this study is to investigate the associations of increased EDC exposure during pregnancy with changes of fetal birthweight and pregnancy duration.
Methods: Individual use of plastic food and liquid packages was evaluated in 493 pregnant patients from the Clinical Gravidity Association Trial and Evaluation (CGATE) cohort using a three item lifestyle questionnaire concerning plastic consumption habits. To assess exposure to EDCs patients were further grouped into risk categories, and the associations with birthweight and pregnancy duration were investigated using a linear regression model.
Results: For none of the investigated plastic consumption habits concerning drinking water, food from cans/plastic or beverage cartons (Tetra Pak) a statistically significant association with birthweight could be found. Moreover, no significant correlation between plastic consumption in regards of drinking water and food from cans/plastic with pregnancy duration could be detected. Interestingly, a statistically significant pregnancy prolongation of 0.4 weeks (p = 0.01, 95% CI: 0.1; 0.7) was observed with increasing consumption of Tetra Pak.
Conclusion: The impact of plastic package consumption during pregnancy does not seem to have a major effect on birthweight or pregnancy duration, however the direction in which the statistically non-significant differences were seen were into the expected direction. Therefore larger studies are warranted to investigate this potentially important epidemiological factor.
Keywords
Endocrine Disrupting Chemicals, EDCs, Plastic Packages, Preterm Birth, Birthweight, Pregnancy Duration
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A new preprint design is coming!
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This preprint is under consideration at Archives of Gynecology and Obstetrics. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Patrick Stelzl
Johannes Kepler Universitat Linz
Corresponding Author
ORCiD: https://orcid.org/0000-0002-5915-7788
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 27 May, 2021
No community comments so far
First submitted
On 15 Dec, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose: Exposure to endocrine disrupting chemicals (EDCs) is ubiquitous in modern civilization and their impact on hormonal regulation in vivid organisms is well established. These substances also seem to play a pivotal role during pregnancy as they might influence birth and pregnancy outcomes, such as fetal birthweight and pregnancy duration.
The objective of this study is to investigate the associations of increased EDC exposure during pregnancy with changes of fetal birthweight and pregnancy duration.
Methods: Individual use of plastic food and liquid packages was evaluated in 493 pregnant patients from the Clinical Gravidity Association Trial and Evaluation (CGATE) cohort using a three item lifestyle questionnaire concerning plastic consumption habits. To assess exposure to EDCs patients were further grouped into risk categories, and the associations with birthweight and pregnancy duration were investigated using a linear regression model.
Results: For none of the investigated plastic consumption habits concerning drinking water, food from cans/plastic or beverage cartons (Tetra Pak) a statistically significant association with birthweight could be found. Moreover, no significant correlation between plastic consumption in regards of drinking water and food from cans/plastic with pregnancy duration could be detected. Interestingly, a statistically significant pregnancy prolongation of 0.4 weeks (p = 0.01, 95% CI: 0.1; 0.7) was observed with increasing consumption of Tetra Pak.
Conclusion: The impact of plastic package consumption during pregnancy does not seem to have a major effect on birthweight or pregnancy duration, however the direction in which the statistically non-significant differences were seen were into the expected direction. Therefore larger studies are warranted to investigate this potentially important epidemiological factor.
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