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Research Article
Chuan-Long Zhu
the First Affiliated Hospital of Nanjing Medical University
Corresponding Author
ORCiD: https://orcid.org/0000-0002-0657-828X
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: With the spread of SARS-CoV-2 around the world, a rising number of studies have been conducted on the epidemiological and clinical characteristics of COVID-19. However, studies about the effect of SARS-CoV-2 on coagulation function are rare. Hence, we aimed to assess the differences and dynamic changes of blood coagulation function in ordinary, severe and critical patients with COCID-19.
Methods: A retrospective study was conducted. Clinical information, including age, routine blood and blood coagulation function, was collected from medical records of COVID-19 patients from January 24 to March 25, 2020 in Huangshi, Hubei Province. According to new pneumonia diagnosis and treatment of COVID-19 (trial version seventh), the patients were divided into ordinary, severe and critical groups.
Results: 261 COVID-19 patients (186 ordinary, 45 severe and 30 critical ones) were enrolled. Average age in critical group (71.47±11.48 years) was the oldest of three subgroups. At admission, statistically differences could be observed for D-dimer, FDP, Platelet and lymphocyte count among three subgroups (P<0.05). During hospitalization, the peak values of coagulation and valley values of blood routine were monitored, and there were significant differences among ordinary, severe and critical patients in D-dimer (0.26±0.46, 1.39±1.51 and 2.89±1.68 mg/L), FDP (3.29±5.52, 23.68±39.07 and 56.11±49.94 μg/ml), platelet [(164±55.53), (171±69.96) and (84±57.80) ×109/L)] and lymphocyte counts [(1.10±0.46), (0.65±0.35) and (0.55±0.31) ×109/L)], respectively (P<0.001). In the critical group, D-dimer and FDP were significantly increased, while platelet count and lymphocyte count were obviously decreased. D-dimer and FDP in the course of disease in severe/critical groups showed a first upward and then downward trend.
Conclusions: Close monitoring of coagulation function could help predict the severity of COVID-19, and guide treatment.
Keywords
Coagulation function, D-dimer, Fibrin/fibrinogen degradation products (FDP), COVID-19, SARS-CoV-2
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research Article
Chuan-Long Zhu
the First Affiliated Hospital of Nanjing Medical University
Corresponding Author
ORCiD: https://orcid.org/0000-0002-0657-828X
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 12 Apr, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Infectious Diseases
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: With the spread of SARS-CoV-2 around the world, a rising number of studies have been conducted on the epidemiological and clinical characteristics of COVID-19. However, studies about the effect of SARS-CoV-2 on coagulation function are rare. Hence, we aimed to assess the differences and dynamic changes of blood coagulation function in ordinary, severe and critical patients with COCID-19.
Methods: A retrospective study was conducted. Clinical information, including age, routine blood and blood coagulation function, was collected from medical records of COVID-19 patients from January 24 to March 25, 2020 in Huangshi, Hubei Province. According to new pneumonia diagnosis and treatment of COVID-19 (trial version seventh), the patients were divided into ordinary, severe and critical groups.
Results: 261 COVID-19 patients (186 ordinary, 45 severe and 30 critical ones) were enrolled. Average age in critical group (71.47±11.48 years) was the oldest of three subgroups. At admission, statistically differences could be observed for D-dimer, FDP, Platelet and lymphocyte count among three subgroups (P<0.05). During hospitalization, the peak values of coagulation and valley values of blood routine were monitored, and there were significant differences among ordinary, severe and critical patients in D-dimer (0.26±0.46, 1.39±1.51 and 2.89±1.68 mg/L), FDP (3.29±5.52, 23.68±39.07 and 56.11±49.94 μg/ml), platelet [(164±55.53), (171±69.96) and (84±57.80) ×109/L)] and lymphocyte counts [(1.10±0.46), (0.65±0.35) and (0.55±0.31) ×109/L)], respectively (P<0.001). In the critical group, D-dimer and FDP were significantly increased, while platelet count and lymphocyte count were obviously decreased. D-dimer and FDP in the course of disease in severe/critical groups showed a first upward and then downward trend.
Conclusions: Close monitoring of coagulation function could help predict the severity of COVID-19, and guide treatment.
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