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Research article
Ehsaneh Taheri
Shaheed Beheshti University of Medical Sciences
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Subjects with normal weight obesity (NOW) are supposed to cardiometabolic disorders. The aim of this study was to investigate the circulating levels of vaspin and leptin and their association with glycemic and lipid profiles in women with NWO compared to controls
Material & Methods: Forty women with BMI:18.5-24.9 kg/m2 and FM ≥ 30% as a NOW group and 30 age matched women with same BMI range and FM<30% as control group were enrolled. Anthropometric measurement, fasting serum levels of fasting blood sugar (FBS), insulin, HbA1c, lipid profiles and also, leptin and vaspin were measured.
Results: The mean ± SD of age were 28.76±4.76 years in NWO group and 29.23 ± 4.50 years in controls. Subjects in NWO group had higher serum level of insulin (9.02 ± 4.75 vs.6.24 ± 2.51, p= 0.009), leptin (17.31 ± 8.10 vs. 9.94 ± 4.30, p<0.001) and HOMA-IR (33.77 ± 20.71 vs. 23.48 ± 10.03, p=0.009) compared to the NWNO group. Serum level of vaspin was higher in NWO (34.82 pg/ml) than control group (27.72 pg/ml),(p=0.12). In NWO subjects, serum level of leptin showed positive association with FBS (r=0.45, p=0.02), insulin (r=0.51, p=0.008), and HOMA-IR (r=0.46, p= 0.02) and vaspin concentration was positively associated with insulin (r=0.36, p= 0.02) and HOMA-IR (r=0.30, p=0.06).
Conclusion: We observed that women with NWO had statistically significant increased concentration of insulin and HOMA-IR index compared to the controls. Higher levels of leptin and vaspin in NWO were associated with glycemic profiles in NWO.
Keywords
Normal Weight Obesity, Adipokines, Glycemic Profile, Lipid Profile
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CURRENT STATUS: Published
View the published article at BMC Endocrine Disorders.
No community comments so far
Submission checks complete
On 02 Nov, 2020
Editorial decision: Accept
On 28 Oct, 2020
No comments provided
Editorial decision: Minor revision
On 14 Oct, 2020
Editor assigned
On 06 Oct, 2020
Submission checks complete
On 05 Oct, 2020
Editor invited
On 05 Oct, 2020
No comments provided
Editorial decision: Minor revision
On 17 Sep, 2020
Editor assigned
On 25 Aug, 2020
Submission checks complete
On 24 Aug, 2020
Editor invited
On 24 Aug, 2020
No comments provided
Editorial decision: Minor revision
On 17 Aug, 2020
Review #1 received
Received 31 Jul, 2020
Reviewer #2 agreed
On 25 Jul, 2020
Review #2 received
Received 25 Jul, 2020
Reviewer #1 agreed
On 22 Jul, 2020
Reviewers invited
Invitations sent on 20 Jul, 2020
Editor assigned
On 05 Jul, 2020
Submission checks complete
On 04 Jul, 2020
Editor invited
On 04 Jul, 2020
Version 1
Posted 01 May, 2020
No comments provided
Review #2 received
Received 11 Jun, 2020
Editorial decision: Minor revision
On 11 Jun, 2020
Review #1 received
Received 21 May, 2020
Reviewer #3 agreed
On 13 May, 2020
Reviewer #2 agreed
On 11 May, 2020
Reviewer #1 agreed
On 10 May, 2020
Reviewers invited
Invitations sent on 08 May, 2020
Editor assigned
On 14 Apr, 2020
Submission checks complete
On 13 Apr, 2020
Editor invited
On 13 Apr, 2020
First submitted
On 09 Apr, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Endocrinology & Metabolism
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at BMC Endocrine Disorders.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Ehsaneh Taheri
Shaheed Beheshti University of Medical Sciences
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Endocrine Disorders.
No community comments so far
Submission checks complete
On 02 Nov, 2020
Editorial decision: Accept
On 28 Oct, 2020
No comments provided
Editorial decision: Minor revision
On 14 Oct, 2020
Editor assigned
On 06 Oct, 2020
Submission checks complete
On 05 Oct, 2020
Editor invited
On 05 Oct, 2020
No comments provided
Editorial decision: Minor revision
On 17 Sep, 2020
Editor assigned
On 25 Aug, 2020
Submission checks complete
On 24 Aug, 2020
Editor invited
On 24 Aug, 2020
No comments provided
Editorial decision: Minor revision
On 17 Aug, 2020
Review #1 received
Received 31 Jul, 2020
Reviewer #2 agreed
On 25 Jul, 2020
Review #2 received
Received 25 Jul, 2020
Reviewer #1 agreed
On 22 Jul, 2020
Reviewers invited
Invitations sent on 20 Jul, 2020
Editor assigned
On 05 Jul, 2020
Submission checks complete
On 04 Jul, 2020
Editor invited
On 04 Jul, 2020
Version 1
Posted 01 May, 2020
No comments provided
Review #2 received
Received 11 Jun, 2020
Editorial decision: Minor revision
On 11 Jun, 2020
Review #1 received
Received 21 May, 2020
Reviewer #3 agreed
On 13 May, 2020
Reviewer #2 agreed
On 11 May, 2020
Reviewer #1 agreed
On 10 May, 2020
Reviewers invited
Invitations sent on 08 May, 2020
Editor assigned
On 14 Apr, 2020
Submission checks complete
On 13 Apr, 2020
Editor invited
On 13 Apr, 2020
First submitted
On 09 Apr, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Endocrinology & Metabolism
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Endocrine Disorders.
Background: Subjects with normal weight obesity (NOW) are supposed to cardiometabolic disorders. The aim of this study was to investigate the circulating levels of vaspin and leptin and their association with glycemic and lipid profiles in women with NWO compared to controls
Material & Methods: Forty women with BMI:18.5-24.9 kg/m2 and FM ≥ 30% as a NOW group and 30 age matched women with same BMI range and FM<30% as control group were enrolled. Anthropometric measurement, fasting serum levels of fasting blood sugar (FBS), insulin, HbA1c, lipid profiles and also, leptin and vaspin were measured.
Results: The mean ± SD of age were 28.76±4.76 years in NWO group and 29.23 ± 4.50 years in controls. Subjects in NWO group had higher serum level of insulin (9.02 ± 4.75 vs.6.24 ± 2.51, p= 0.009), leptin (17.31 ± 8.10 vs. 9.94 ± 4.30, p<0.001) and HOMA-IR (33.77 ± 20.71 vs. 23.48 ± 10.03, p=0.009) compared to the NWNO group. Serum level of vaspin was higher in NWO (34.82 pg/ml) than control group (27.72 pg/ml),(p=0.12). In NWO subjects, serum level of leptin showed positive association with FBS (r=0.45, p=0.02), insulin (r=0.51, p=0.008), and HOMA-IR (r=0.46, p= 0.02) and vaspin concentration was positively associated with insulin (r=0.36, p= 0.02) and HOMA-IR (r=0.30, p=0.06).
Conclusion: We observed that women with NWO had statistically significant increased concentration of insulin and HOMA-IR index compared to the controls. Higher levels of leptin and vaspin in NWO were associated with glycemic profiles in NWO.
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