See the published version of this preprint at BMC Endocrine Disorders.
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Research article
Ehsaneh Taheri
Shaheed Beheshti University of Medical Sciences
Corresponding Author
Parvin Mirmiran
Shahid Beheshti university of Medical Science
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Individuals with normal weight obesity (NWO) are prone to cardiometabolic disorders. This study aims to investigate the circulating levels of vaspin, leptin and their association with glycemic and lipid profiles in women with NWO.
Methods: Forty women with body mass index (BMI) = 18.5-24.9 kg/m2 and fat mass (FM) ≥ 30% were assigned in the NWO group. Thirty age-matched women with identical BMI range and FM < 30% (normal weight non-obese; NWNO) were considered as a control group. In addition to anthropometric measurements, glycemic and lipid profiles and also, circulating levels of leptin and vaspin were measured.
Results: The mean ± standard deviation (SD) age of participants was 28.76 ± 4.76 years in the NWO group and 29.23 ± 4.50 years in the control group. The NWO group had higher mean serum levels of insulin (9.02 ± 4.75 vs. 6.24 ± 2.51, P = 0.009), leptin (17.31 ± 8.10 vs. 9.94 ± 4.30, P < 0.001) and homeostatic model assessment of insulin resistance (HOMA-IR) (33.77 ± 20.71 vs. 23.48 ± 10.03, P = 0.009) compared to the NWNO group. Serum level of vaspin was higher in the NWO group compared to the control group (34.82 pg/ml vs. 27.72 pg/ml, respectively, P = 0.12). In NWO group, serum levels of leptin correlated positively with FBS (r = 0.45, P = 0.02), insulin (r = 0.51, P = 0.008), and HOMA-IR (r = 0.46, P = 0.02) and vaspin concentration was positively associated with insulin (r = 0.36, P = 0.02) and HOMA-IR (r = 0.30, P = 0.06).
Conclusion: It is concluded that the concentration of insulin and HOMA-IR index were significantly higher in women with NWO compared to NWNO. Higher levels of leptin and vaspin in the NWO group were associated with glycemic profiles.
Keywords
Normal weight obesity, Adipokines, Glycemic profile, Lipid profile
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CURRENT STATUS: Published
View the published article at BMC Endocrine Disorders.
No community comments so far
Submission checks complete
On 02 Nov, 2020
Editorial decision: Accept
On 28 Oct, 2020
Version 4
Posted 19 Oct, 2020
No comments provided
Editorial decision: Minor revision
On 14 Oct, 2020
Editor assigned
On 06 Oct, 2020
Submission checks complete
On 05 Oct, 2020
Editor invited
On 05 Oct, 2020
No comments provided
Editorial decision: Minor revision
On 17 Sep, 2020
Editor assigned
On 25 Aug, 2020
Submission checks complete
On 24 Aug, 2020
Editor invited
On 24 Aug, 2020
No comments provided
Editorial decision: Minor revision
On 17 Aug, 2020
Review #1 received
Received 31 Jul, 2020
Reviewer #2 agreed
On 25 Jul, 2020
Review #2 received
Received 25 Jul, 2020
Reviewer #1 agreed
On 22 Jul, 2020
Reviewers invited
Invitations sent on 20 Jul, 2020
Editor assigned
On 05 Jul, 2020
Submission checks complete
On 04 Jul, 2020
Editor invited
On 04 Jul, 2020
No comments provided
Review #2 received
Received 11 Jun, 2020
Editorial decision: Minor revision
On 11 Jun, 2020
Review #1 received
Received 21 May, 2020
Reviewer #3 agreed
On 13 May, 2020
Reviewer #2 agreed
On 11 May, 2020
Reviewer #1 agreed
On 10 May, 2020
Reviewers invited
Invitations sent on 08 May, 2020
Editor assigned
On 14 Apr, 2020
Submission checks complete
On 13 Apr, 2020
Editor invited
On 13 Apr, 2020
First submitted
On 09 Apr, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Endocrinology & Metabolism
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at BMC Endocrine Disorders.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Ehsaneh Taheri
Shaheed Beheshti University of Medical Sciences
Corresponding Author
Parvin Mirmiran
Shahid Beheshti university of Medical Science
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Endocrine Disorders.
No community comments so far
Submission checks complete
On 02 Nov, 2020
Editorial decision: Accept
On 28 Oct, 2020
Version 4
Posted 19 Oct, 2020
No comments provided
Editorial decision: Minor revision
On 14 Oct, 2020
Editor assigned
On 06 Oct, 2020
Submission checks complete
On 05 Oct, 2020
Editor invited
On 05 Oct, 2020
No comments provided
Editorial decision: Minor revision
On 17 Sep, 2020
Editor assigned
On 25 Aug, 2020
Submission checks complete
On 24 Aug, 2020
Editor invited
On 24 Aug, 2020
No comments provided
Editorial decision: Minor revision
On 17 Aug, 2020
Review #1 received
Received 31 Jul, 2020
Reviewer #2 agreed
On 25 Jul, 2020
Review #2 received
Received 25 Jul, 2020
Reviewer #1 agreed
On 22 Jul, 2020
Reviewers invited
Invitations sent on 20 Jul, 2020
Editor assigned
On 05 Jul, 2020
Submission checks complete
On 04 Jul, 2020
Editor invited
On 04 Jul, 2020
No comments provided
Review #2 received
Received 11 Jun, 2020
Editorial decision: Minor revision
On 11 Jun, 2020
Review #1 received
Received 21 May, 2020
Reviewer #3 agreed
On 13 May, 2020
Reviewer #2 agreed
On 11 May, 2020
Reviewer #1 agreed
On 10 May, 2020
Reviewers invited
Invitations sent on 08 May, 2020
Editor assigned
On 14 Apr, 2020
Submission checks complete
On 13 Apr, 2020
Editor invited
On 13 Apr, 2020
First submitted
On 09 Apr, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Endocrinology & Metabolism
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Endocrine Disorders.
Background: Individuals with normal weight obesity (NWO) are prone to cardiometabolic disorders. This study aims to investigate the circulating levels of vaspin, leptin and their association with glycemic and lipid profiles in women with NWO.
Methods: Forty women with body mass index (BMI) = 18.5-24.9 kg/m2 and fat mass (FM) ≥ 30% were assigned in the NWO group. Thirty age-matched women with identical BMI range and FM < 30% (normal weight non-obese; NWNO) were considered as a control group. In addition to anthropometric measurements, glycemic and lipid profiles and also, circulating levels of leptin and vaspin were measured.
Results: The mean ± standard deviation (SD) age of participants was 28.76 ± 4.76 years in the NWO group and 29.23 ± 4.50 years in the control group. The NWO group had higher mean serum levels of insulin (9.02 ± 4.75 vs. 6.24 ± 2.51, P = 0.009), leptin (17.31 ± 8.10 vs. 9.94 ± 4.30, P < 0.001) and homeostatic model assessment of insulin resistance (HOMA-IR) (33.77 ± 20.71 vs. 23.48 ± 10.03, P = 0.009) compared to the NWNO group. Serum level of vaspin was higher in the NWO group compared to the control group (34.82 pg/ml vs. 27.72 pg/ml, respectively, P = 0.12). In NWO group, serum levels of leptin correlated positively with FBS (r = 0.45, P = 0.02), insulin (r = 0.51, P = 0.008), and HOMA-IR (r = 0.46, P = 0.02) and vaspin concentration was positively associated with insulin (r = 0.36, P = 0.02) and HOMA-IR (r = 0.30, P = 0.06).
Conclusion: It is concluded that the concentration of insulin and HOMA-IR index were significantly higher in women with NWO compared to NWNO. Higher levels of leptin and vaspin in the NWO group were associated with glycemic profiles.
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