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Research Article
Hirokazu Sakaguchi
Osaka University
Corresponding Author
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Although choriocapillaris flow deficit (CFD) around choroidal neovascularization (CNV) is less associated with CNV activity in myopic eyes, there are no reports investigating its size as an indicator of CNV activity. We investigated the relationship between CFD and high myopia-related CNV. In this retrospective, observational study, patients underwent optical coherence tomography angiography (OCTA) with split-spectrum amplitude decorrelation angiography for diagnosing pathological myopic CNV (mCNV); CFD features around CNV margins were evaluated. Of the 33 eyes (30 patients), 11 (33.3%) had active mCNV, and 22 (66.7%) had inactive CNV. Five eyes (15.2%) were treatment-naïve, while the remainder previously underwent anti-vascular endothelial growth factor therapy. On OCTA, blood flow signals were detected in CNV in the outer retinal layer in 28 (84.8%) eyes, including all active cases (11 cases) and 17 (77.3%) of 22 inactive cases. CNV flow signal size correlated significantly with activity (P = 0.002). CFD around CNV was observed in 18 eyes (54.5%), eight of which had active CNV. CFD size correlated significantly with CNV activity (P = 0.014). The size of both the CFD area around CNV and CNV flow signal area are useful indicators of CNV activity in eyes with mCNV, which may help determine treatment timing.
Keywords
choriocapillaris flow deficit (CFD), choroidal neovascularization (CNV), eye disease
Figure 1
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No competing interests reported.
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CURRENT STATUS: Under Revision
Version 1
Posted 23 Feb, 2021
No community comments so far
Editorial decision: Major revision
On 06 Apr, 2021
Reviews received
Received 04 Apr, 2021
Reviewers agreed
On 29 Mar, 2021
Reviews received
Received 26 Mar, 2021
Reviewers agreed
On 21 Mar, 2021
Reviewers invited
Invitations sent on 08 Mar, 2021
Editor assigned
On 08 Mar, 2021
Editor invited
On 11 Feb, 2021
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On 11 Feb, 2021
First submitted
On 09 Feb, 2021
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Subject Areas
Ophthalmology
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This preprint is under consideration at Scientific Reports. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Hirokazu Sakaguchi
Osaka University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Revision
Version 1
Posted 23 Feb, 2021
No community comments so far
Editorial decision: Major revision
On 06 Apr, 2021
Reviews received
Received 04 Apr, 2021
Reviewers agreed
On 29 Mar, 2021
Reviews received
Received 26 Mar, 2021
Reviewers agreed
On 21 Mar, 2021
Reviewers invited
Invitations sent on 08 Mar, 2021
Editor assigned
On 08 Mar, 2021
Editor invited
On 11 Feb, 2021
Submission checks complete
On 11 Feb, 2021
First submitted
On 09 Feb, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Ophthalmology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Although choriocapillaris flow deficit (CFD) around choroidal neovascularization (CNV) is less associated with CNV activity in myopic eyes, there are no reports investigating its size as an indicator of CNV activity. We investigated the relationship between CFD and high myopia-related CNV. In this retrospective, observational study, patients underwent optical coherence tomography angiography (OCTA) with split-spectrum amplitude decorrelation angiography for diagnosing pathological myopic CNV (mCNV); CFD features around CNV margins were evaluated. Of the 33 eyes (30 patients), 11 (33.3%) had active mCNV, and 22 (66.7%) had inactive CNV. Five eyes (15.2%) were treatment-naïve, while the remainder previously underwent anti-vascular endothelial growth factor therapy. On OCTA, blood flow signals were detected in CNV in the outer retinal layer in 28 (84.8%) eyes, including all active cases (11 cases) and 17 (77.3%) of 22 inactive cases. CNV flow signal size correlated significantly with activity (P = 0.002). CFD around CNV was observed in 18 eyes (54.5%), eight of which had active CNV. CFD size correlated significantly with CNV activity (P = 0.014). The size of both the CFD area around CNV and CNV flow signal area are useful indicators of CNV activity in eyes with mCNV, which may help determine treatment timing.
Figure 1
Figure 2
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