This preprint is under consideration at BMC Infectious Diseases. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Huan-ling Wang
Peking Union Medical College Hospital
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objectives
We analyzed the peripheral blood lymphocyte subsets of human immunodeficiency virus (HIV) negative patients infected with pneumocystis pneumonia (PCP), aimed to find out the relationship between the levels of different types of lymphocytes with the prognosis of patients.
Methods
We retrospectively reviewed HIV negative patients with PCP diagnosed in our department, all the eligible patients underwent lymphocyte subsets analysis on admission.
Results
A total of 88 HIV negative PCP patients were enrolled in the study. In univariate analyses, low CD4+ T cell count, low CD8+ T cell count, and low natural killer cell (NK cell) count were associated with in-hospital mortality. CD8+ T cell count≤300/μL was found to be an independent risk factor for poor prognosis in multivariate logistical regression analysis (p=0.015, OR=11.526, 95%CI=1.597-83.158). Although low CD4+ T cell and NK cell counts were not independent risk factors, the mortality rates of PCP patients decreased sequentially with the increased levels of CD4+ T cell and NK cell counts.
Conclusion
The immunity process of Pneumocystis jirovecii infection is complex and crucial. We proposed that lymphocyte subsets give clinicians better understandings of patients 3 immune status, early identification of potential lethal patients and decision making, such as adjusting immunosuppressive regimen and choosing appropriate patient monitoring level.
Keywords
Pneumocystis peumonia, lymphocyte subsets, prognosis, immunosuppression, infectionandimmunity.
Figure 1
Figure 2
Figure 3
No competing interests reported.
Loading...
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 23 Feb, 2021
No community comments so far
Editorial decision: Major revision
On 08 Apr, 2021
Reviews received
Received 21 Mar, 2021
Reviewers agreed
On 26 Feb, 2021
Reviewers agreed
On 18 Feb, 2021
Reviewers invited
Invitations sent on 15 Feb, 2021
Editor assigned
On 15 Feb, 2021
Editor invited
On 15 Feb, 2021
Submission checks complete
On 15 Feb, 2021
First submitted
On 09 Feb, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Infectious Diseases
Learn more about our company.
This preprint is under consideration at BMC Infectious Diseases. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Huan-ling Wang
Peking Union Medical College Hospital
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 23 Feb, 2021
No community comments so far
Editorial decision: Major revision
On 08 Apr, 2021
Reviews received
Received 21 Mar, 2021
Reviewers agreed
On 26 Feb, 2021
Reviewers agreed
On 18 Feb, 2021
Reviewers invited
Invitations sent on 15 Feb, 2021
Editor assigned
On 15 Feb, 2021
Editor invited
On 15 Feb, 2021
Submission checks complete
On 15 Feb, 2021
First submitted
On 09 Feb, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Infectious Diseases
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objectives
We analyzed the peripheral blood lymphocyte subsets of human immunodeficiency virus (HIV) negative patients infected with pneumocystis pneumonia (PCP), aimed to find out the relationship between the levels of different types of lymphocytes with the prognosis of patients.
Methods
We retrospectively reviewed HIV negative patients with PCP diagnosed in our department, all the eligible patients underwent lymphocyte subsets analysis on admission.
Results
A total of 88 HIV negative PCP patients were enrolled in the study. In univariate analyses, low CD4+ T cell count, low CD8+ T cell count, and low natural killer cell (NK cell) count were associated with in-hospital mortality. CD8+ T cell count≤300/μL was found to be an independent risk factor for poor prognosis in multivariate logistical regression analysis (p=0.015, OR=11.526, 95%CI=1.597-83.158). Although low CD4+ T cell and NK cell counts were not independent risk factors, the mortality rates of PCP patients decreased sequentially with the increased levels of CD4+ T cell and NK cell counts.
Conclusion
The immunity process of Pneumocystis jirovecii infection is complex and crucial. We proposed that lymphocyte subsets give clinicians better understandings of patients 3 immune status, early identification of potential lethal patients and decision making, such as adjusting immunosuppressive regimen and choosing appropriate patient monitoring level.
Figure 1
Figure 2
Figure 3
No competing interests reported.
Loading...