The recent Smriti Mallapaty’work (Nature. News, 10 November 2022) highlights the role of recombination in the evolution of the SARS-CoV-2. It seems hard to deal the origin of the virus as a whole. The SARS-CoV-2genome is a mosaic of regions or parts, each with their own origin. The SARS-CoV-2’s closest known relative is a bat virus found in Laos called BANAL-52, which can therefore infect human cells. Furthermore, BANAL-52 don’t contain the so-called furin cleavage site on the spike protein that further aids the entry of SARS-CoV-2 into human cells. So, the furin site was a key piece in the virus “mosaic”. However, The SARS-CoV-2 furin site “gain-of-function” was being made against the CGG-CGG genetic footprint encoding the polybasic arginine dimer. For SARS-CoV-2 the only output to the CGG-CGGinstability is to proceed with synonymous substitutions (silent mutations) keeping the arginine dimer from the furin site. Theaim of this work is to provide updated data on the plausibility of this evolution in the coding of thatarginine dimer. Using the NCBI Virus database as a source of information, the sample of SARS-CoV-2 spike proteins, with releasedate November 1-10, 2022, shows that 78 out of 27281 (0.28 %) sequences show a synonymous base substitution in the CGG-CGG. This percentage is twice of samples retrieved in August 2022.