This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research
Ye Fan
Xinqiao Hospital Third Military Medical University
Corresponding Author
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This work is licensed under a CC BY 4.0 License. Read Full License
Background: Tuberculous pleural effusion (TPE) is one of the most prevalent causes of exudative pleural effusion. As it is curable, early diagnosis is essential. Nevertheless, direct examination is not so sensitive while thoracoscopy is invasive and resource-demanding.
Objective: To seek a less-invasive but also cost-effective substitute for medical thoracoscopy to identify TPE.
Methods: We retrospectively collected 662 patients with pleural effusions who have undergone thoracoscopy as the training cohort, developed a predictive model and then validated it in another independent cohort. Independent predictor was screened by univariate analysis, feature selection and multivariate logistic regression. A predictive nomogram model was then established and evaluated by calibration, discrimination and clinical values. A standard model with a pleural adenosine deaminase (plADA) cut-off value at 40 IU/L was applied for comparison.
Results: A lower plADA threshold at 24.5 IU/L was identified to discriminate TPE from other etiologies. Furthermore, serum tumor marker CA153 and Cyfra21.1, pleural lactic acid dehydrogenase and pleural interstitial cells were also identified as independent predictors (p<0.05) in multivariate logistic regression. The multivariate nomogram model presented good calibration, discrimination and clinical values, superior to the standard model. Excellent discrimination was demonstrated by the Harrell’s concordance index of 0.993 in the training cohort and 0.968 in the validation cohort. Furthermore, decision curve analysis demonstrated that the multivariate nomogram model added more benefit to patients with TPE.
Conclusion: A multivariate nomogram model involved biochemical examinations and thoracentesis performed well in TPE clinical diagnosis among undetermined pleural effusions with approximate efficacy to medical thoracoscopy.
Keywords
Pleural effusion, Tuberculous pleurisy
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research
Ye Fan
Xinqiao Hospital Third Military Medical University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 22 Feb, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Infectious Diseases
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Tuberculous pleural effusion (TPE) is one of the most prevalent causes of exudative pleural effusion. As it is curable, early diagnosis is essential. Nevertheless, direct examination is not so sensitive while thoracoscopy is invasive and resource-demanding.
Objective: To seek a less-invasive but also cost-effective substitute for medical thoracoscopy to identify TPE.
Methods: We retrospectively collected 662 patients with pleural effusions who have undergone thoracoscopy as the training cohort, developed a predictive model and then validated it in another independent cohort. Independent predictor was screened by univariate analysis, feature selection and multivariate logistic regression. A predictive nomogram model was then established and evaluated by calibration, discrimination and clinical values. A standard model with a pleural adenosine deaminase (plADA) cut-off value at 40 IU/L was applied for comparison.
Results: A lower plADA threshold at 24.5 IU/L was identified to discriminate TPE from other etiologies. Furthermore, serum tumor marker CA153 and Cyfra21.1, pleural lactic acid dehydrogenase and pleural interstitial cells were also identified as independent predictors (p<0.05) in multivariate logistic regression. The multivariate nomogram model presented good calibration, discrimination and clinical values, superior to the standard model. Excellent discrimination was demonstrated by the Harrell’s concordance index of 0.993 in the training cohort and 0.968 in the validation cohort. Furthermore, decision curve analysis demonstrated that the multivariate nomogram model added more benefit to patients with TPE.
Conclusion: A multivariate nomogram model involved biochemical examinations and thoracentesis performed well in TPE clinical diagnosis among undetermined pleural effusions with approximate efficacy to medical thoracoscopy.
Figure 1
Figure 2
Figure 3
Figure 4
This is a list of supplementary files associated with this preprint. Click to download.
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