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Research Article
Ghadi S. Azzahrani
King Abdulaziz University
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: the clinical investigations regarding the efficacy of different fluoride products are limited. Aim: to compare the effectiveness of Colgateâ PreviDentâ and MITM varnishes to the standard (1.23%) acidulated phosphate fluoride gel in the remineralization of non-cavitated proximal incipient lesions.
Design: this randomized clinical trial included 91 lesions which were assigned to three groups. We performed an initial examination, and 3- and 6-month follow-ups.
Result: teeth treated with both MITM and Colgateâ PreviDentâ varnishes showed statistically significant improvements in caries progression. In the Colgateâ PreviDentâ group, nine surfaces with white spots with dryness remained unchanged, one surface changed to a white spot without dryness, and one surface improved to a sound surface. In the MITM group, nine surfaces with white spots with dryness remained unchanged, and one surface changed to a white spot without dryness. Only teeth treated with MI varnishTM showed significant improvements radiographically. Teeth affected by outer enamel caries remained the same or improved to sound surfaces. Additionally, teeth with inner enamel caries remained the same. Conclusion: both MITM and Colgateâ PreviDentâ varnishes are effective therapies to remineralize non-cavitated incipient lesions. However, there were no significant differences in the radiographic outcomes among the three types of varnish applications.
Trial registration
This clinical trial was registered at ClinicalTrials.gov (no. NCT03925740), and the first registration date was on 24/04/2019. Ethical approval was obtained from the institutional ethical committee at King Abdulaziz University (REC-013-01019).All methods were carried out in accordance to the ethical committee at King Abdulaziz University guidelines and regulations.
Keywords
Fluoride varnish, Remineralization, Non-cavitated interproximal
Figure 1
No competing interests reported.
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This is a preprint. It has not completed peer review.
Research Article
Ghadi S. Azzahrani
King Abdulaziz University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 09 Mar, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Dentistry
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: the clinical investigations regarding the efficacy of different fluoride products are limited. Aim: to compare the effectiveness of Colgateâ PreviDentâ and MITM varnishes to the standard (1.23%) acidulated phosphate fluoride gel in the remineralization of non-cavitated proximal incipient lesions.
Design: this randomized clinical trial included 91 lesions which were assigned to three groups. We performed an initial examination, and 3- and 6-month follow-ups.
Result: teeth treated with both MITM and Colgateâ PreviDentâ varnishes showed statistically significant improvements in caries progression. In the Colgateâ PreviDentâ group, nine surfaces with white spots with dryness remained unchanged, one surface changed to a white spot without dryness, and one surface improved to a sound surface. In the MITM group, nine surfaces with white spots with dryness remained unchanged, and one surface changed to a white spot without dryness. Only teeth treated with MI varnishTM showed significant improvements radiographically. Teeth affected by outer enamel caries remained the same or improved to sound surfaces. Additionally, teeth with inner enamel caries remained the same. Conclusion: both MITM and Colgateâ PreviDentâ varnishes are effective therapies to remineralize non-cavitated incipient lesions. However, there were no significant differences in the radiographic outcomes among the three types of varnish applications.
Trial registration
This clinical trial was registered at ClinicalTrials.gov (no. NCT03925740), and the first registration date was on 24/04/2019. Ethical approval was obtained from the institutional ethical committee at King Abdulaziz University (REC-013-01019).All methods were carried out in accordance to the ethical committee at King Abdulaziz University guidelines and regulations.
Figure 1
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