Under a background of coordinated open-pit and underground mining engineering practice in the Pingshuo mining area, a combination of numerical simulations and similar-model experiments was used to study the influence of the underground mining direction on slope deformation in two dimensions. The results show that the disturbance caused by inverse-slope mining is more obvious than that caused by along-slope mining. Underground mining presents an asymmetric influence on the open-pit slope; the slope rock mass on the open-off cut side is disturbed more than that on the coal-wall side. Compared with the slope in front of the advancing direction of the underground mining face, the degree of rock-mass damage and stress concentration of the slope of the open-off cut side are more serious. As such, in coordinated open-pit and underground mining practice, an along-slope mining direction is recommended to reduce adverse effects on slope stability and improve the recovery rate of coal resources.