This preprint is under consideration at BMC Cardiovascular Disorders. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
Research article
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Hyperuricemia is associated with aortic dissection and cardiovascular diseases. The implication of high serum uric acid (UA) level after acute aortic dissection repair remains unknown. The aim of this study is to explore the role of peri-operative serum UA level in predicting 30-days mortality with acute type A aortic dissection (AAAD) patients, who underwent surgery.
Methods and Results: 209 consecutive AAAD patients were included, 14.3% (n=30) were dead within 30 days after surgery. By univariate analysis, we found AAAD repair patients with 30-days mortality had a higher prevalence of cerebral malperfusion, lower pre-operative fibrinogen, longer cardiopulmonary bypass and aortic crossclamp time, and higher post-operative day 1 (POD1) creatinine and urea levels. Both pre-operative (433.80±152.59 vs. 373.46±108.31mmol/L, P=0.038) and POD1 (559.78±162.23 vs. 391.29±145.19 mmol/L, P=0.000) UA level were higher in mortality group than in survival group. In regression model, only cerebral malperfusion (OR, 7.937, 95% CI, 1.252-50.323; P=0.028) and POD1 UA level (OR, 1.006; 95% CI, 1.003-1.009; P=0.000) were independent predictors of 30-days mortality in AAAD repair patients. According to the ROC curve, the POD1 UA level provided positive value for 30-days mortality in AAAD repair patients with 0.799 areas under the curve. The optimum cutoff value selected by ROC curve was 500.15 mmol/L, with a sensitivity of 69.2% and a specificity of 81.7%.
Conclusion: Pre- and post-operative hyperuricemia are potentially associated with worsened outcomes in AAAD surgery patients. The POD1 UA level has a predictive role in 30-days mortality in AAAD repair patients.
Keywords
Type A aortic dissection, Uric acid, Outcomes, Regression analysis,
Figure 1
Loading...
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 12 Feb, 2021
No community comments so far
Editorial decision: Major revision
On 04 Apr, 2021
Review #2 received
Received 30 Mar, 2021
Reviewer #2 agreed
On 14 Mar, 2021
Review #1 received
Received 22 Feb, 2021
Reviewer #1 agreed
On 18 Feb, 2021
Reviewers invited
Invitations sent on 14 Feb, 2021
Editor invited
On 09 Feb, 2021
First submitted
On 03 Jan, 2021
Editor assigned
On 03 Jan, 2021
Submission checks complete
On 03 Jan, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Learn more about our company.
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
This preprint is under consideration at BMC Cardiovascular Disorders. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 12 Feb, 2021
No community comments so far
Editorial decision: Major revision
On 04 Apr, 2021
Review #2 received
Received 30 Mar, 2021
Reviewer #2 agreed
On 14 Mar, 2021
Review #1 received
Received 22 Feb, 2021
Reviewer #1 agreed
On 18 Feb, 2021
Reviewers invited
Invitations sent on 14 Feb, 2021
Editor invited
On 09 Feb, 2021
First submitted
On 03 Jan, 2021
Editor assigned
On 03 Jan, 2021
Submission checks complete
On 03 Jan, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Hyperuricemia is associated with aortic dissection and cardiovascular diseases. The implication of high serum uric acid (UA) level after acute aortic dissection repair remains unknown. The aim of this study is to explore the role of peri-operative serum UA level in predicting 30-days mortality with acute type A aortic dissection (AAAD) patients, who underwent surgery.
Methods and Results: 209 consecutive AAAD patients were included, 14.3% (n=30) were dead within 30 days after surgery. By univariate analysis, we found AAAD repair patients with 30-days mortality had a higher prevalence of cerebral malperfusion, lower pre-operative fibrinogen, longer cardiopulmonary bypass and aortic crossclamp time, and higher post-operative day 1 (POD1) creatinine and urea levels. Both pre-operative (433.80±152.59 vs. 373.46±108.31mmol/L, P=0.038) and POD1 (559.78±162.23 vs. 391.29±145.19 mmol/L, P=0.000) UA level were higher in mortality group than in survival group. In regression model, only cerebral malperfusion (OR, 7.937, 95% CI, 1.252-50.323; P=0.028) and POD1 UA level (OR, 1.006; 95% CI, 1.003-1.009; P=0.000) were independent predictors of 30-days mortality in AAAD repair patients. According to the ROC curve, the POD1 UA level provided positive value for 30-days mortality in AAAD repair patients with 0.799 areas under the curve. The optimum cutoff value selected by ROC curve was 500.15 mmol/L, with a sensitivity of 69.2% and a specificity of 81.7%.
Conclusion: Pre- and post-operative hyperuricemia are potentially associated with worsened outcomes in AAAD surgery patients. The POD1 UA level has a predictive role in 30-days mortality in AAAD repair patients.
Figure 1
Loading...