This preprint is under consideration at The International Journal of Cardiovascular Imaging. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Research Article
Reza Piri
University of Southern Denmark
Corresponding Author
ORCiD: https://orcid.org/0000-0002-6379-3373
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose
To examine 2-year changes in carotid and aortic 18F-sodium fluoride (NaF) uptake in both healthy controls and angina pectoris patients.
Methods
Twenty-nine healthy subjects and 20 angina pectoris patients underwent 90-min NaF-PET/CT twice two years apart. The carotids and three sections of the aorta (arch, thoracic, abdominal) were manually segmented. NaF uptake was expressed as the mean and total standardized uptake values without and with partial volume correction (SUVmean, SUVtotal and cSUVmean, cSUVtotal).
Results
Insignificant tendencies were higher NaF uptake in angina patients at both time points with less uptake in healthy subjects and higher uptake in angina patients after 2 years. Thus, aortic cSUVmean of angina patients was 1.14±0.35 and 1.29±0.71 at baseline and after 2 years vs. 0.99±0.31 and 0.95±0.28 in healthy subjects. A similar pattern was observed for the carotid cSUVmean. NaF uptake at baseline could not predict a change in CT-calcification after 2 years. NaF uptake in all parts of the aorta correlated positively with age.
Conclusions
Slightly, but consistently, higher arterial NaF uptake in the angina group indicated more ongoing microcalcification at both time points in patients than in healthy subjects. The 2-year changes were very small in both groups, albeit with a tendency of slight decreases among healthy controls and slight increases in angina patients despite statin therapy in half of these.
Keywords
18F-sodium fluoride, NaF, microcalcifications, positron emission tomography/computed tomography, atherosclerosis, disease progression
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CURRENT STATUS: Under Review
Version 1
Posted 24 Feb, 2021
No community comments so far
Editor invited
On 26 Mar, 2021
Reviews received
Received 14 Feb, 2021
Reviewers invited
Invitations sent on 12 Feb, 2021
Editor assigned
On 11 Feb, 2021
First submitted
On 10 Feb, 2021
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Subject Areas
Cardiac & Cardiovascular Systems
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This preprint is under consideration at The International Journal of Cardiovascular Imaging. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Reza Piri
University of Southern Denmark
Corresponding Author
ORCiD: https://orcid.org/0000-0002-6379-3373
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 24 Feb, 2021
No community comments so far
Editor invited
On 26 Mar, 2021
Reviews received
Received 14 Feb, 2021
Reviewers invited
Invitations sent on 12 Feb, 2021
Editor assigned
On 11 Feb, 2021
First submitted
On 10 Feb, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Cardiac & Cardiovascular Systems
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose
To examine 2-year changes in carotid and aortic 18F-sodium fluoride (NaF) uptake in both healthy controls and angina pectoris patients.
Methods
Twenty-nine healthy subjects and 20 angina pectoris patients underwent 90-min NaF-PET/CT twice two years apart. The carotids and three sections of the aorta (arch, thoracic, abdominal) were manually segmented. NaF uptake was expressed as the mean and total standardized uptake values without and with partial volume correction (SUVmean, SUVtotal and cSUVmean, cSUVtotal).
Results
Insignificant tendencies were higher NaF uptake in angina patients at both time points with less uptake in healthy subjects and higher uptake in angina patients after 2 years. Thus, aortic cSUVmean of angina patients was 1.14±0.35 and 1.29±0.71 at baseline and after 2 years vs. 0.99±0.31 and 0.95±0.28 in healthy subjects. A similar pattern was observed for the carotid cSUVmean. NaF uptake at baseline could not predict a change in CT-calcification after 2 years. NaF uptake in all parts of the aorta correlated positively with age.
Conclusions
Slightly, but consistently, higher arterial NaF uptake in the angina group indicated more ongoing microcalcification at both time points in patients than in healthy subjects. The 2-year changes were very small in both groups, albeit with a tendency of slight decreases among healthy controls and slight increases in angina patients despite statin therapy in half of these.
Figure 1
Figure 2
Figure 3
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