Clinical Characteristics and Long-term Surgical Outcome of Spinal Myxopapillary Ependymoma: A French Cohort of 101 Patients

Abstract

Purpose: Myxopapillary ependymoma (MPE) is the most frequent tumor affecting the medullary conus. The surgical therapeutic management is still debated and only few studies have focused on the postoperative clinical outcome of patients. This study aimed to demonstrate long-term postoperative outcome and to assess the predictive factors of recurrence as well as the clinical evolution of these patients.

Methods: From 1984 to 2019, in four French centers 101 adult patients diagnosed with MPE were retrospectively included.

Results: Median age at surgery was 39 years. Median tumor size was 50mm and lesions were multifocal in 13% of patients. All patients benefited from surgery and one patient received postoperative radiotherapy. Gross total resection was obtained in 75% of cases. Sixteen percent of patients presented recurrence after a median follow-up of 70 months. Progression free survival at 5 and 10 years were respectively estimated at 83% and 79%. After multivariable analysis, sacral localization, and subtotal resection were shown to be independently associated with tumor recurrence. 85% of the patients had a favorable evolution concerning pain. Twelve percent of the patients presented a postoperative deterioration of sphincter function and 4% of motor function.

Conclusion: Surgery alone is an acceptable option for MPE patients. Patients with sacral location or incomplete resection are at high risk of recurrence and should be carefully monitored. 

Introduction

Myxopapillary ependymoma (MPE) is a rare tumor, with an estimated incidence of 1 out of one million inhabitants [1]. The 2006 WHO classification assigned to MPE a grade 1, but the grade will be changed to grade 2 in the next classification [2, 3]. MPE occurred almost exclusively within the conus and the filum terminale [3]. MPE is the most frequent tumor of the conus medularis [3, 4]. The natural course of MPE remains largely unknown. Some articles on untreated MPE report an evolution towards tumor growth and neurological degradation within a few years [5, 6]. The average duration of symptoms preceding diagnosis ranges from 13 months to 8.3 years since they are slow growing [6–8].Most patients present a long history of non-specific symptoms such as low back pain with or without motor, sphincter or sensory signs [9].

Surgical tumor gross total resection (GTR) is the gold standard treatment. The impact of adjuvant radiotherapy (RT) remains currently debated [9–11]. Young age, subtotal resection (STR) and capsule violation are described as unfavorable prognostic factors associated with tumor recurrence [12–15]. Few studies have evaluated the functional postoperative outcome [16].

This study aims to: (i) analyze patient and tumor characteristics as well as the long-term clinical outcome after surgery and (ii) clarify the management of recurrences.

Methods

Ethics Statement

The data collected during the study was stored in a computer file in accordance with the law of the French Data Protection Act of January 6, 1978 amended in 2004. The protocol can be found in the reference methodology MR003 chapter adopted by the Commission Nationale de l’Informatique et des Libertés (No 2219024 v0) in agreement with the policies of the University Hospitals involved in this project. In accordance with the ethical standards of our hospital’s institutional review board, the Committee for the Protection of Human Subjects, and French law, written informed consent was not needed for demographic, physiological and hospital-outcome data analyses because this observational study did not modify existing diagnostic or therapeutic strategies; however, patients were informed of their inclusion in the study. The manuscript was prepared in accordance with the STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) statement.

Patients

From 1984 to 2019, 101 patients with an histological diagnosis of MPE (according to the WHO classification of tumors of the central nervous system 2016 [3]) and treated in four French institutions were included in this study. Patients younger than 15 years of age, and patients who had a lack of data in their medical report were excluded.

All information regarding the patient, the clinical and the surgical procedures as well as periodic check-ups were anonymously extracted from medical records and analyzed by the authors. Patients’ motor and sphincter dysfunctions were assessed using motor and urodynamic testing respectively that allowed comparisons between the pre- and postoperative periods. Radiological data were collected from reports or original images if available and included the number of vertebral segments affected, size and location of the tumor, presence of cyst, syringomyelia, bone scalloping, hemorrhage, T1- an T2- weighted MRI signal and gadolinium enhancement.

Statistical analysis

All statistical analyses were performed with the software R (version 4.0.0, 2020-04-24), and figures with GraphPad PRISM 5.00. Age at the time of the surgery, gender, body mass index, tobacco use and, quality of resection were collected.

Resection was classified as GTR by radiologist if no residual tumor was seen on first injected postoperative MRI, 6 weeks after surgery, as near GTR for >90% of tumor volume resection, as subtotal for 50-90% of tumor volume resection and partial for <50% of tumor volume resection.

The tumor was defined as “large” if: (i) it measured more than 5cm [17] or, (ii) when the size was unknown, if it extended over at least four vertebral bodies. Intraoperative bleeding, suspected pre-operative diagnosis, duration of surgery, blood transfusion, pre- and post-operative symptoms, time from first symptoms to surgery and outcome at last follow-up were also collected. For patients presenting recurrence, we registered the time from surgery to recurrence (progression free survival, (PFS)) as well as the location and treatment of the recurrence.

The age of male patients was significantly different from a normal distribution (Shapiro-Wilk test p=0.04). Thus, age differences between men and women were analyzed with a Wilcoxon test. In order to determine the association between univariate factors and recurrence and for the calculation of odd ratios and 95% confidence intervals we used Fisher’s exact text to analyze 2-way contingency tables.

To assess PFS we used Kaplan-Meier estimates with the “survival” package in R. Tumor recurrence represented the events. We used the log-rank test to assess the influence of the different factors listed above on tumor recurrence. Factors achieving P ≤ 0.05 in our univariable analyses were entered into the multivariable model. Multivariable analysis was then performed using Cox stepwise regression analysis to define the independent contribution of each prognostic factor. Statistical tests were two-sided and P < 0.05 defined statistical significance.

Data Availability Statement

Anonymized data will be shared on request from any qualified investigator.

Results

Patient and tumor characteristics

One hundred and one patients were included. Patient characteristics are detailed in Table 1. Women were older than men (median=45 vs 34 years, P=0.004). The lumbar localization was the most frequent (94%), more specifically the upper segments, as the L1, L2 or L3 vertebral levels were involved in 88% of patients. Thirteen patients (13%) presented multifocal MPE (2, 3 and 4 locations in 8, 3 and 2 patients respectively). 

Pain was the main symptom: 90 patients (90%): 63 patients (62%) suffered from low back pain with radiculalgia, 19 patients (19%) isolated low back pain and 8 patients (8%) isolated radiculalgia. A nocturnal exacerbation was described in 20% of the cases.

The other symptoms such as sphincter, motor and sensory dysfunctions were almost equally distributed (41%, 35% and 37% of patients respectively). Among patients with sphincter dysfunction, 83% had chronic or acute urinary retention, 35% had urinary incontinence, 34% complained of abnormal anal sphincter function and 15% of erectile dysfunction.

 Onset was abrupt in 12 patients and six of them showed intratumoral hemorrhage on MRI. Furthermore, one of these patients presented a sudden headache caused by subarachnoid hemorrhage with negative digital subtraction arteriography. MRI signals were not specific, the most frequent pattern was an iso signal T1 and a hypersignal T2. However, Gadolinium enhancement was constant. Diagnosis of MPE was preoperatively evoked for 61 patients (66%)

Surgical Treatment

All patients underwent surgery. One patient (1%) underwent adjuvant radiotherapy. A GTR was achieved in 76 patients (75%). Near GTR was obtained in 8 patients (8%) and subtotal resection in 16 patients (16%). One (1%) patient had a partial resection. Dura matter was perforated by the tumor in 9 cases. GTR was obtained more frequently for solitary lesions compared to multifocal lesions (84% vs 15% P<0.001).

Post-operative complications

Six patients presented a postoperative cerebro-spinal fluid leakage (two required surgical treatment), four patients had an infection of the operative site (two required surgical treatment), five patients developed a meningocele (three required surgical treatment), three patients had arachnoiditis (one of them required surgical treatment), and one patient developed pneumocephalus. Other non-specific complications were reported: one pulmonary embolism, one pulmonary atelectasis and one ileus.

Clinical evolution

The median follow-up was 70 months [1 – 422]. No patient died during the follow-up. The evolutions of the main symptoms (motor dysfunction, sphincter dysfunction and pain) are summarized in Fig. 1. Most patients had functional improvement: 24/41 (59%) patients with sphincter dysfunction improved and 12/41 (29%) remained stable; motor function was improved in 24/35 (69%) patients and 7/35 (20%) were stable. Pain decreased or resolved in 76/90 (84%) patients.

Worsening of symptoms was recorded for 30 patients (30%) (Hypoesthesia n=14, motor function n=4, sphincter function n=12, pain n=3, deformation n=1). All motor declines occurred in patients presenting a preoperative motor deficit. Postoperative sphincter deterioration was present in 12 patients, including seven with normal preoperative sphincter function. Three patients needed permanent self-catheterization, and the others had perineal hypoesthesia or occasional urinary incontinence. Age, sex, overweight, tobacco use, large tumor sizes and time from first symptom to surgery were not associated with increased risk of functional decline (motor or sphincter). Preoperative deficits and significant tumor adherences seem to increase the risk of functional deterioration, although results did not reach statistical significance (P=0.07 and P=0.08 respectively).

Tumor recurrence

Recurrence occurred in 16 patients (16%). One of them underwent initial adjuvant radiotherapy. Data are summarized in Table 2. The median time to recurrence was 25 months. Two recurrences occurred for initially undiagnosed bifocal lesions. Thirteen patients (13%) presented a local recurrence and 3 patients (3 %) a distant location. For five patients, recurrence was multinodular. PFS at 5 and 10 years were estimated at 83% and 79% respectively (Fig. 2).

Factors associated with tumor recurrence

In univariable analysis, preoperative factors significantly associated with recurrence were: involvement of at least one sacral level (OR=15.7 IC95%=[4.4-60.5], P<0.001), large tumors (OR=6.3, IC95%=[1.56-27.5], P=0.005) and multifocal lesions (OR=4.3, IC95%=[1.17-15.6], P=0.03). The intraoperative data that was significantly associated with recurrence were: subtotal resection (OR= 25 IC95%=[ 6.4-117], P<0.001), dural perforation by the tumor (OR=8.9 IC95%=[1.6-52], P=0.005), transfusion or bleeding >500cc (OR=8.6 IC95%=[1.75-58.2], P=0.002), surgery ≥3hours (OR=8.6 IC95%=[1.2-189], P=0.03) and substantial adherence (OR=3.7 IC95%=[1.1-13.7], P=0.045) (Fig. 3 and Table 3). The recurrence rate was 4% (3/76 patients) in the GTR group versus 52% (13/25 patients) in the STR group.

The multivariable model (Table 3) retained incomplete resection (OR=11.2 IC95%=[2.1-60.6], P=0.005) and the involvement of at least one sacral level (OR=7.7 IC95%[1.8-32.7], p=0.005) as being independently associated with tumor recurrence.

Management of recurrence

Among 16 recurrences (16%), 8 (50%) were treated with a second surgery, 2 (12.5%) with radiation therapy, 1 (6%) by surgery associated with radiotherapy, 1 (6%) with chemotherapy (temozolomide), and 2 (12.5%) followed by close monitoring. Two patients refused treatment, and both deteriorated to complete paraplegia. Four patients (25%) treated with surgery developed a new recurrence requiring additional treatment (radiotherapy and/or surgery). Tumors were controlled at last follow-up in 12/16 patients (75%) (Table 2).

Discussion

Surgery

In most cases, a GTR was obtained. With this attitude, despite larger tumors than those classically described, our recurrence rate (16%) and PFS at 5 and 10 years was comparable or lower than those described in the literature although median tumor size is larger [9–11, 18]. However, in our study, the rate of GTR was higher than that found in the literature. This factor is important in limiting the risk of recurrence (4% in the GTR group versus vs 52% in the STR group in our study) It is not possible to determine whether the good results of this series are related to our therapeutic strategy (no adjuvant radiotherapy) or to the high rate of GTR.

Clinical evolution and toxicity

The postoperative evolution was marked by an improvement in pain levels for almost all patients. Motor and sphincter disorders were partly or completely improved in most patients independently of the duration of the symptoms. This surgery has a rather high postoperative complication rate. Nearly a third of patients had a neurological complication. Most often it is a well-tolerated sensory deficit. Only patients with preoperative motor deficits showed an aggravation of their motor symptoms. It is important to note that the bladder function of a significant amount of the patients was impaired, including patients with no sign of such disorder before surgery. However, not all patients underwent a preoperative urodynamic assessment. Therefore, surgeons need to warn their patients of this risk.

Recurrences

Risk factors for recurrence included classic factors such as incomplete resection or multiple locations. Age under 30 or 35 is a commonly described as unfavorable prognostic factor, but studies generally combine pediatric and adult populations [15, 18]. In our study, focused on adult population, young adults under 30 years do not appear to be more prone to recurrence than other patients. Therefore, it does not seem legitimate to propose a different treatment for this age category. In this study, intraoperative capsular infraction did not appear to be a negative risk factor, although this information was not included in all the records.

It is interesting to note that sacral location represents a strong risk factor for recurrence. Biomolecular analyses could be of interest to determine whether sacral tumors present different molecular profiles, particularly concerning the expression of genes involved in cranio-caudal development. Previous work has been done on the HoxB13 gene that is expressed during the development of the terminal filum [19]. After the early embryonic stages, Hoxb13 is no longer expressed in the terminal filum nor in the spinal cord of healthy subjects.[20] Molecular profiling of ependymomas has shown that high expression of Hox genes in spinal ependymomas compared to intracranial localizations [21]. In addition, HoxB13 gene expression is a sensitive and specific marker of MPE in spinal cord tumors [20, 22]. The HoxB13 gene is known to be involved in various tumors of the pelvic region [23]. It would therefore be interesting to evaluate the expression of this gene in MPE with recurrence as well as in sacral localized MPE. To the best of our knowledge, no biomolecular factor has ever been associated with tumor recurrence. In our study, proliferative index (Ki67 / MIB-1 was not associated to recurrence.

Our study confirms data from the literature underlining the need of GTR in order to reduce the risk of recurrence. However, it cannot always be achieved, especially for multifocal tumors associated with increased risk of recurrence. In patients treated with GTR, only two developed recurrence. One had a giant tumor (140mm) and the other had a sacral localization (L5-S2). It is thus necessary to reassure patients treated with GTR. One of the patients had a cervical distal recurrence. It seems appropriate to perform in patients at risk of recurrence (incomplete resection, giant or multifocal tumor...) a follow-up including pan-medullary MRI. In two patients the bifocal nature of the tumor had not been diagnosed preoperatively, and only one of the two lesions was removed. These two patients developed recurrence. It therefore seems important to search carefully for multiple locations.

Therapeutic strategy

The appropriate timing of surgery is still debated as this tumor is benign with a slow evolution. Most patients recover from their preoperative symptoms and the postoperative complication rate cannot be neglected, especially sphincter dysfunctions. Offering a close clinical and radiological monitoring to patients with drugs-controlled symptoms could be of interest [24]. Surgery should be considered on a case-by-case basis and recommended only to patients with disabling symptoms or radiological proof of tumor progression. However, in such a case, patients should not be lost to follow-up. Since only few insights into the natural course of these tumors are described in medical literature, the risk would be to let giant lesions develop, which would eventually be surgically challenging.

Despite the 35 year-period of analysis, few changes were noticed in the management of patients. All patients but one had preoperative MRI. All patients with a follow-up had serial MRI. The surgical technique described in operative reports did not change except dural sealing (fibrin sealant). No patient had intraoperative neuromonitoring. It could have been helpful for invasive tumors in order to maximize the GTR rate and minimize postoperative complications. However, most of the aggravations involved sphincter functions and not motor functions.

The interest of systematic adjuvant radiotherapy after incomplete resection is debated. In our series, half of the patients who received an incomplete resection had recurrences, including the one patient who had received adjuvant radiotherapy. However, it is interesting to note that all the patients with recurrence who accepted salvage treatment are now controlled, except one who was multimetastatic from the outset. Our attitude is therefore to keep radiotherapy as a treatment option in cases with non-operable recurrences or as an adjuvant to salvage surgery. However, Akyurek et al concluded that adjuvant RT appeared to significantly reduce the rate of tumor progression [13], while Pica et al stated that only postoperative high-dose RT reduced the risk of recurrence [11]. Only results provided by a randomized controlled trial comparing surgery versus surgery plus RT could bring the debate to a conclusion.

The two patients who refused treatment for their recurrence declined to paraplegia. It therefore seems essential to monitor patients carefully over a long period of time, as late recurrences are not uncommon and early management of recurrences may be easier.

Limitations

First, due to the low incidence of this tumor, our study is retrospective. Some data is missing, and some patients were lost to follow-up. Monitoring of symptoms before and after surgery seems to be a major factor to consider in this benign tumor. Being a retrospective study, data was extracted from medical records and there was no validated clinical score scale. Second, only one patient received first-line adjuvant radiotherapy. We cannot therefore compare efficacy of surgery versus radiotherapy. Due to the low incidence of this tumor, it is difficult to gather a large cohort of patients. This work focuses on 101 cases which is one of the largest clinical study with that from Weber et al [10].

Conclusion

Surgery alone demonstrates good results concerning the treatment of MPE, even for young adults. GTR is strongly associated with a lower rate of recurrence. Patients with sacral or multifocal lesions are highly prone to recurrence. Further biomolecular studies may be of interest to understand inter-tumor heterogeneity.

Declarations

Funding: none.

Conflicts of interest/Competing interests: None

Ethics approval: The protocol can be found in the reference methodology MR003 chapter adopted by the Commission Nationale de l’Informatique et des Libertés (No 2219024 v0) in agreement with the policies of the University Hospitals involved in this project.

Consent to participate: In accordance with the ethical standards of our hospital’s institutional review board, the Committee for the Protection of Human Subjects, and French law, written informed consent was not needed for demographic, physiological and hospital-outcome data analyses because this observational study did not modify existing diagnostic or therapeutic strategies; however, patients were informed of their inclusion in the study.

Consent for publication: not applicable.

Availability of data and material: Anonymized data will be shared on request from any qualified investigator.

Code availability: Not applicable.

Author Contributions: Conceptualization, A.S.M and B.M.; methodology, A.S.M and B.M.; validation, all the authors.; formal analysis, A.S.M., F.Be. and B.M..; investigation, A.S.M., S.T., G.L., S.G., M.P., C.A., F.P., A.I., L.F., F.Bi and B.M..; resources, B.M..; data curation, A.S.M., S.T., G.L., S.G., M.P., C.A., F.P., A.I., L.F., F.Bi and B.M. ; writing—original draft preparation, A.S.M., A.A. and B.M.; writing—review and editing, all the authors.; supervision, B.M. and A.C.. All authors have read and agreed to the published version of the manuscript.

References

1. Bates JE, Choi G, Milano MT (2016) Myxopapillary ependymoma: a SEER analysis of epidemiology and outcomes. J Neurooncol 129:251–258. https://doi.org/10.1007/s11060-016-2167-0
2. Ellison DW, Aldape KD, Capper D, et al (2020) cIMPACT-NOW update 7: advancing the molecular classification of ependymal tumors. Brain Pathol. https://doi.org/10.1111/bpa.12866
3. Louis DN, Ohgaki H, Wiestler OD, et al (2016) Ependymal tumours. In: WHO Classification of Tumours of the Central Nervous System. 4th Edition Revised, the International Agency for Research on Cancer (IARC). pp 101–115
4. Abul-Kasim K, Thurnher MM, McKeever P, Sundgren PC (2008) Intradural spinal tumors: current classification and MRI features. Neuroradiology 50:301–314. https://doi.org/10.1007/s00234-007-0345-7
5. Pusat S, Erbaş YC, Göçmen S, et al (2019) Natural Course of Myxopapillary Ependymoma: Unusual Case Report and Review of Literature. World Neurosurg 121:239–242. https://doi.org/10.1016/j.wneu.2018.10.028
6. Ngo TP, Dufton J, Stern PJ, Islam O (2013) Myxopapillary ependymoma as a cause of back pain in a young male – A case report. J Can Chiropr Assoc 57:150–155
7. Asazuma T, Toyama Y, Suzuki N, et al (1999) Ependymomas of the spinal cord and cauda equina: An analysis of 26 cases and a review of the literature. Spinal Cord 37:753–759. https://doi.org/10.1038/sj.sc.3100902
8. Sakai Y, Matsuyama Y, Katayama Y, et al (2009) Spinal myxopapillary ependymoma: neurological deterioration in patients treated with surgery. Spine (Phila Pa 1976) 34:1619–1624. https://doi.org/10.1097/BRS.0b013e3181a983d8
9. Feldman WB, Clark AJ, Safaee M, et al (2013) Tumor control after surgery for spinal myxopapillary ependymomas: distinct outcomes in adults versus children: A systematic review. Journal of Neurosurgery: Spine 19:471–476. https://doi.org/10.3171/2013.6.SPINE12927
10. Weber DC, Wang Y, Miller R, et al (2015) Long-term outcome of patients with spinal myxopapillary ependymoma: treatment results from the MD Anderson Cancer Center and institutions from the Rare Cancer Network. Neuro-oncology 17:588–595. https://doi.org/10.1093/neuonc/nou293
11. Pica A, Miller R, Villà S, et al (2009) The results of surgery, with or without radiotherapy, for primary spinal myxopapillary ependymoma: a retrospective study from the rare cancer network. Int J Radiat Oncol Biol Phys 74:1114–1120. https://doi.org/10.1016/j.ijrobp.2008.09.034
12. Pesce A, Palmieri M, Armocida D, et al (2019) Spinal Myxopapillary Ependymoma: The Sapienza University Experience and Comprehensive Literature Review Concerning the Clinical Course of 1602 Patients. World Neurosurg 129:245–253. https://doi.org/10.1016/j.wneu.2019.05.206
13. Akyurek S, Chang EL, Yu T-K, et al (2006) Spinal myxopapillary ependymoma outcomes in patients treated with surgery and radiotherapy at M.D. Anderson Cancer Center. J Neurooncol 80:177–183. https://doi.org/10.1007/s11060-006-9169-2
14. Abdulaziz M, Mallory GW, Bydon M, et al (2015) Outcomes following myxopapillary ependymoma resection: the importance of capsule integrity. Neurosurg Focus 39:E8. https://doi.org/10.3171/2015.5.FOCUS15164
15. Tsai CJ, Wang Y, Allen PK, et al (2014) Outcomes after surgery and radiotherapy for spinal myxopapillary ependymoma: update of the MD Anderson Cancer Center experience. Neurosurgery 75:205–214; discussion 213-214. https://doi.org/10.1227/NEU.0000000000000408
16. Bagley CA, Wilson S, Kothbauer KF, et al (2009) Long term outcomes following surgical resection of myxopapillary ependymomas. Neurosurg Rev 32:321–334; discussion 334. https://doi.org/10.1007/s10143-009-0190-8
17. Liu M, Jevtic S, Markham-Coultes K, et al (2018) Investigating the efficacy of a combination Aβ-targeted treatment in a mouse model of Alzheimer’s disease. Brain Research 1678:138–145. https://doi.org/10.1016/j.brainres.2017.10.015
18. Kukreja S, Ambekar S, Sharma M, et al (2015) Outcome predictors in the management of spinal myxopapillary ependymoma: an integrative survival analysis. World Neurosurg 83:852–859. https://doi.org/10.1016/j.wneu.2014.08.006
19. Wellik DM (2007) Hox patterning of the vertebrate axial skeleton. Dev Dyn 236:2454–2463. https://doi.org/10.1002/dvdy.21286
20. Barton VN, Donson AM, Kleinschmidt-DeMasters BK, et al (2010) Unique Molecular Characteristics of Pediatric Myxopapillary Ependymoma. Brain Pathol 20:560–570. https://doi.org/10.1111/j.1750-3639.2009.00333.x
21. Palm T, Figarella-Branger D, Chapon F, et al (2009) Expression profiling of ependymomas unravels localization and tumor grade-specific tumorigenesis. Cancer 115:3955–3968. https://doi.org/10.1002/cncr.24476
22. Gu S, Gu W, Shou J, et al (2017) The Molecular Feature of HOX Gene Family in the Intramedullary Spinal Tumors. Spine 42:291–297. https://doi.org/10.1097/BRS.0000000000000889
23. Lotan TL, Torres A, Zhang M, et al (2017) Somatic molecular subtyping of prostate tumors from HOXB13 G84E carriers. Oncotarget 8:22772–22782. https://doi.org/10.18632/oncotarget.15196
24. Amelot A, Peyre M, Mokhtari K, et al (2020) Primary Extraosseous Spinal Ewing’s Sarcomas (PESES): Should we be more aware about Diagnosis? Spine (Phila Pa 1976). https://doi.org/10.1097/BRS.0000000000003784

Tables

Table 1: Patient characteristics

Values are expressed as number of patients (%) unless otherwise indicated.

Table 2: Characteristics of patients with recurrence.

STR= Subtotal resection, GTR= gross total resection, RT= radiotherapy, PFS = progression free survival

Table 3. Univariable and multivariable analyses of recurrence-associated factors. 

Sacral level : at least one sacral level is involved. Thoracic level : At least one thoracic level is involved.