Since measurement errors are inevitable in practice, and they are not considered in the existing process performance index, we propose an estimation method of process performance index for two-parameter exponential distribution with measurement errors. In this paper, the relationship between the unobservable actual value and measurement value is considered as an additive measurement error model. The maximum likelihood estimation method is considered to obtain the unknown parameters. In addition, we also use the Bootstrap method to construct confidence intervals of process performance index. The performance of the proposed estimation is investigated in terms of bias, mean square error (MSE) and average interval length. Simulation results show that the proposed estimator outperforms the estimates that do not account for measurement error. Finally, an example of the mileage data of the military personnel carrier is given to illustrate the implementation of the proposed estimation method.