What is the impact of post-COVID-19 syndrome on health-related quality of life and associated factors: a cross-sectional analysis

doi:10.21203/rs.3.rs-2337041/v1

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What is the impact of post-COVID-19 syndrome on health-related quality of life and associated factors: a cross-sectional analysis

https://doi.org/10.21203/rs.3.rs-2337041/v1

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published 22 Mar, 2023

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Background.

After the acute phase, symptoms or sequelae related to post-COVID-19 syndrome may persist for months. We aim to measure their impact on health-related quality of life (HRQoL) and to investigate influencing factors, among patients, previously hospitalized and not, followed up to 12 months.

Methods.

We present the cross-sectional analysis of a prospective study, including patients referred to the post-COVID-19 service. Questionnaires and scales administered at 3, 6, 12 months were: Short-Form 36-item questionnaire (SF-36); Visual Analogue Scale of the EQ5D (EQ-VAS); in a subgroup, Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI-II) and Pittsburgh Sleep Quality Index (PSQI). Linear regression was used to assess for the presence of a trend over time by month of evaluation after the acute infection (continuous measure in month); two different linear regression models were fitted to identify factors associated with HRQoL.

Results.

We considered the first assessment of each participant (n = 572): 235 (41%), 175 (31%) and 118 (21%) patients were evaluated 3 months [median 3.5 (IQR 2.9-3-9)], 6 months [5.6 (5.0-6.5)], and more than 6 months [9.6 (8.3–14.7)], after the acute infection, respectively. The mean scores in SF-36 and in EQ-VAS were significantly lower than the Italian normative values and remained stable over time, except the mental components score (MCS) of the SF-36 and EQ-VAS which resulted in lower ratings at the last observations. Female gender, presence of comorbidities, and corticosteroids treatment during acute COVID-19, were associated with lower scores in SF-36 and EQ-VAS; patients previously hospitalized (54%) reported higher MCS. Alterations in BAI, BDI-II, and PSQI, evaluated in a subgroup of 265 participants, were associated with lower ratings in SF-36 and EQ-VAS.

Conclusions.

This study provides evidence of a significantly bad perception of health status among persons with post-COVID-19 syndrome, associated with female gender and, indirectly, with disease severity. In case of anxious-depressive symptoms and sleep disorders, a worse HRQoL was also reported. A systematic monitoring of these aspects is recommended to properly manage the post-COVID-19 period.

Post-COVID-19 syndrome

post-acute sequelae of COVID-19 infection (PASC)

post-COVID-19 condition

long COVID

health-related quality of life

the Short-Form 36-item questionnaire

physical health

mental health

neuropsychiatric symptoms

sleep disorders

SARS-CoV-2 infection, after the end of the acute phase, can result in heterogeneous clinical manifestations that preclude a full return to the previous state of health. Quality of life is a multidimensional concept that refers to an “individuals’ perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, and standards” and is influenced by both, physical and mental health status of a person [1]. The measure of health perception in the population is crucial to assess the benefit of health care interventions and to target services. A comprehensive assessment of quality of life require instruments able to capture subjectivity and multidimensionality. To be of practical use, the measure must be brief, easy to use and comprehensive. The Short-Form 36-item questionnaire (SF-36) and the Euro-Qol-5 Dimension (EQ-5D) include these features, in fact they are widely used to assess multi-dimensional domains of health and well-being of different target populations [2]. “Long COVID” is commonly used to describe signs and symptoms that continue or develop after acute COVID-19, both in ongoing symptomatic COVID-19 (from 4 to 12 weeks after the acute phase) and in postCOVID-19 syndrome (for more than 12 weeks and not explained by an alternative diagnosis) [3]. It has been estimated that it may occur in up to 25% of patients [3, 4]. The post COVID-19 syndrome may have a negative impact on health-related quality of life (HRQoL), but the majority of the studies uses not homogeneous generic HRQoL assessment tools, and only few studies include a systematic assessment through validate instruments [2, 5, 6]. Furthermore, little is known about long-term sequelae, as the available reports present short observation periods limited to the first 6 months after acute infection, few up to 12 months [6, 7]. In addition, almost all the published analyses are focused on previously hospitalized patients [5–7], rather than non-hospitalized patients with asymptomatic or pauci-symptomatic forms of COVID-19, who represent the majority of the population. Finally, understanding the burden of this condition, and who is at greatest risk of lower HRQoL due to COVID-19 long-term complications, may help to target preventive strategies and provide support for rehabilitation and targeted interventions [7–10].

The objectives of this study, were to measure the impact of post-COVID-19 syndrome on self-reported HRQoL and health status perception, and to investigate influencing factors, in patients with and without prior hospitalization, followed up to 12 months after the acute infection, enrolled in the NEUROCOVID study.

Study design and study population

NEUROCOVID is an ongoing prospective and monocentric study conducted at the National Institute for Infectious Diseases “L. Spallanzani” IRCCS in Rome, Italy, enrolling patients during the acute phase of COVID-19 and/or during the post-COVID-19 period. The study protocol (NeuroCovid Study, version 2.0, January 08, 2021), approved by the Ethical Committee of the Institute (approval number 265/2021), included four main sub-studies aimed (1) to assess patients’ neuropsychological and neurocognitive profile, (2) to evaluate HRQoL self-reported by the patients, (3) to describe any peculiar neuroradiological findings and (4) to compare immunological and virological data on blood and cerebrospinal fluid, analyzing the evolution of all these aspects over time. Patients were asked to adhere to one or more specific sub-studies, driven by clinical decision. All the patients with 18 years or older and with documented SARS-CoV-2 infection, ongoing or previous, were considered eligible after having signed a specific informed. Patients with cerebral focal pathologies, major depression in progress, presence of psychosis and other serious psychiatric pathologies, current drug use, opioid treatment, abuse of psychiatric drugs, visual impairment, motor deficit of the dominant hand, mental delay, lack of command of the Italian language and cultural disadvantage were excluded from the study.

Here, we present a cross-sectional analysis including patients referred to our post-COVID-19 outpatient service, with and without prior hospitalization, from June 2020 to October 2021, evaluated 3 months after the acute infection and, according to clinical decision, at 6 and 12 months, approximately. Each participant agreed to be enrolled in the second sub-study (HRQoL evaluation), a subgroup in the first one (neuropsychological assessment). Demographic, clinical and pharmacological data were collected anonymously into an Electronic Case Report Forms (eCRF); subjects were identified by numeric codes only, password protected.

Questionnaires

The psychological instruments used in this study were chosen based on their psychometric properties and ability to measure self-perception of health status and HRQoL [11, 12]. This assessment was carried out through two specific tools, SF-36 and EQ-5D, and patients were asked to fill them at each visit. The validated Italian version of both instruments, SF-36 [13] and EQ-5D (available at the EuroQol website http://www.euroqol.org), was administered and Italian normative values reported in earlier studies were used as comparison [13–15].

The SF-36 [13, 16] is a self-administered questionnaire containing 36 items which takes about five/ten minutes to be completed; it may be applied to people having many different types of treatment or conditions and in all the different states of health. It is one of the most widely employed generic measures of HRQoL, used to evaluate individual patients, to estimate the cost-effectiveness of a treatment and to monitor and compare the disease burden; in fact, it has been shown to discriminate between subjects with different chronic conditions and between subjects with different severity levels of the same disease [13, 17]. The SF-36 questionnaire measures mental and physical health by considering eight multi items dimensions, covering functional status, well-being, and overall evaluation of health: items are claimed to detect positive as well as negative states of health. In six of the eight dimensions, patients are asked to rate their responses on three- or six-point scales (box). For each dimension, item scores are coded, summed, and transformed on to a scale from 0 (worst health) to 100 (best health). The SF-36 comprises eight health scales: physical role functioning (PF, 10 items), role limitations–physical (RP, 4 items), bodily pain (BP, 2 items), general health perceptions (GH, 5 items), vitality (VT, 4 items), social role functioning (SF, 2 items), emotional role functioning (RE, 3 items), and mental health (MH, 5 items). Two core dimensions of health, physical (PH) and mental (MH), can be derived from these eight scales in order to obtain a mental components score (MCS) and a physical components score (PCS).

The EQ-5D [18, 19] was built with the aim of becoming a generic and extremely flexible tool for measuring the self-perception of quality of life, short and easy to use in self-administration. Although recently an expanded five-level version of the EQ-5D instrument (EQ-5D-5L) has become available and was translated for use across countries, the original three-level version of the EQ-5D (EQ-5D-3L), here referred to as EQ-5D, was used for our study. The EQ-5D is made up of two separate sections. The first section asks for a subjective evaluation of five dimensions of health (mobility, self-care, daily activities, pain/ discomfort and anxiety/depression) on three severity level (1. no problems, 2. some problems, 3. extreme limitation). The aggregation of the answers represents the respondent's state of health and allows to highlight the presence/absence of any problems and their intensity. The second section of the EQ-5D includes a self-rating of “your health today” using a visual analogue scale (VAS) graphically represented by a graduated scale ranging from 0 (the worst possible state of health) to 100 (the best possible health state) on which the interview indicates their perceived level of health. For the present study, we considered only the VAS score of the EQ-5D (EQ-VAS).

Neuropsychiatric symptom assessment

In a subgroup of patients enrolled in the sub-study consisting of a complete neuropsychological assessment, the Beck Anxiety Inventory (BAI), the Beck Depression Inventory (BDI II) and the Pittsburgh Sleep Quality Index (PSQI) were administered in order to assess the presence of anxiety and depressive symptoms and sleep disorders, respectively.

The BAI is a self-report tool that allows to assess the severity of anxiety symptoms in adults, through a questionnaire of 21 items (descriptions of symptoms of somatic, subjective or phobia-related anxiety), to be evaluated on a four-point scale (from 0 to 3) [20, 21].

The BDI-II is a self-report tool that allows to assess the presence and intensity of symptoms correlated to depression. This test of 21 items returns a total score and two other scores relating to somatic-affective area (which concerns the somatic-affective manifestations of depression such as loss of interest, loss of energy, changes in sleep and appetite, shaking and crying) and to cognitive area (which concerns cognitive manifestations such as pessimism, guilt, self-criticism) [22, 23].

The PSQI is a self-assessment scale consisting of 19 items, grouped into 7 composite items, evaluated on a scale from 0 to 3, which give the overall score of the PSQI, ranging from 0 to 21. These 7 composite items represent subjective quality of sleep, sleep latency, sleep duration, habitual sleep efficacy, sleep disturbances, hypnotic drug use, and disturbances during the day [24].

Statistical analyses

Descriptive characteristics were provided using medians and interquartile ranges (IQR) for continuous variables, and frequencies and percentages for categorical variables. Student’s T-test was employed to compare SF-36 and EQ-VAS mean scores to the normative values, and a linear regression was used to assess for the presence of a trend over time by month of evaluation after the acute infection (continuous measure in month). Finally, two different linear regression models were fitted. The first one was built using as dependent variable, scores in SF-36 (splitted in PCS and MCS) and in EQ-VAS, and as covariates, demographic, clinical and therapeutic variables, including distance from the acute infection. This association was studied in both uni- and multivariable analyses. In the subgroup of patients with neuropsychiatric symptoms’ evaluation, linear regression, was used in order to explore the correlation between alterations in BAI, BDI II, and PSQI, with the perception of PH and MH status and HRQoL. A statistically significant difference in the variables tested was indicated as p-value < 0.05 (two-sided). Statistical analysis was performed using STATA 15.1 software.

Descriptive analysis

Out of a total of 914 assessments, we considered the first one of each patient (n = 572). The median age was 55 years (IQR 47–62), 303 (53%) were male, 215 (38%) had at least one comorbidity, 235 (41%), 175 (31%) and 118 (21%) patients were evaluated 3 months [median 3.5 (IQR 2.9-3-9)], 6 months [5.6 (5.0-6.5)], and more than 6 months [9.6 (8.3–14.7)], after the acute infection, respectively. Patients with a previous hospitalization were 309 (54%) and the median time from acute infection was 4.8 months (IQR 3.6–7.1). General baseline patients’ characteristics and the management during the hospital admission are reported in Table 1.

Table 1

Patients’ characteristics at baseline.
	Characteristics of Study Population n = 572
Demographic
Gender
male, n (%)	303 (53.0%)
female, n (%)	269 (47.0%)
Age, years, median (IQR)	55 (47–62)
Comorbidities
Presence of comorbidities, n (%)	215 (37.6%)
Number of comorbidities
1, n (%)	152 (26.6%)
2, n (%)	44 (7.7%)
≥3, n (%)	19 (3.3%)
Distance from acute phase
Months from acute phase, median (IQR)	4.8 (3.6–7.1)
3 months, n (%)	235 (41.1%)
6 months, n (%)	175 (30.6%)
>6 months, n (%)	118 (20.6%)
Previous hospitalization, n (%)	309 (54.0%)
Non-invasive ventilation, n (%)	104 (18.2%)
Intensive Care Unit, n (%)	11 (1.9%)
Treatment in the acute phase
corticosteroids, n (%)	323 (56.5%)
remdesivir, n (%)	145 (25.4%)
immunotherapy, n (%)	10 (1.8%)
heparin, n (%)	258 (45.1%)

IQR InterQuartile Range, n number of participants.

HRQoL assessment

The mean scores of the two dimensions of health, PCS and MCS, investigated by the SF-36 questionnaire, were 63 (SD 25) and 60 (23), respectively. When compared to the reference population [11], the mean ratings of each subscale assessed in SF-36 were significantly lower; similarly, the mean EQ-VAS score was 70 (19) for the entire study population, lower than the Italian normative value (p < 0.001) [15]. Comparisons are reported in Table 2. During the period of observation, the over mentioned scores remained stable over time, with the exception of MCS and EQ-VAS which resulted in lower ratings at the last observations (Fig. 1).

Table 2

Mean scores in SF-36 and in EQ-VAS for study population compared to the Italian normative values.
	Study Population, mean (SD)	Italian Normative Population, mean (SD)	p-value*
SF-36 subscales
pf, Physical Function	74.7 (24.6)	84.5 (23.2)	< 0.001
rp, Role Physical	51.5 (43.3)	78.2 (35.9)	< 0.001
bp, Bodily Pain	66.0 (28.5)	73.7 (27.7)	< 0.001
gh, General Health	60.6 (21.4)	65.2 (22.2)	< 0.001
VT, Vitality	52.2 (21.3)	61.9 (20.7)	< 0.001
SF, Social Functioning	63.7 (25.4)	77.4 (23.3)	< 0.001
RE, Role Emotional	57.9 (42.6)	76.2 (37.3)	< 0.001
mh, Mental Health	64.5 (20.9)	66.6 (20.9)	0.003
EQ-5D
EQ-VAS	70.1 (18.8)	77.7 (19.1)	< 0.001
SD standard deviation, SF-36 short-form 36-item questionnaire, EQ-VAS visual analogue scale score of the EQ-5D. *p-values refer to student’s t-test.

Neuropsychiatric symptoms assessment

Analysis of neuropsychiatric symptoms was performed in a subgroup of a total of 256 patients and we found that scores of the BAI scale for self-reported anxiety symptoms were above the 85° percentile in 141/295 (48%) patients (85°-90° percentile anxiety bordering on pathological aspects, 91°-95° anxiety index of unease, > 95° disabling anxiety), and for the BDI-II scale for self-reported depressive symptoms, somatic-affective and cognitive symptoms respectively, were above the 85° percentile in 134/295 (45%) patients (85°-90° percentile depressive symptoms bordering on pathological aspects, 91°-95° depressive symptoms index of unease, > 95° disabling depressive symptoms). In addition, the pathological scores (≥ 5) on the PSQI scale for the self-perceived sleep quality, evaluated in the same population, were reported from 85/295 (29%) patients, highlighting alterations in sleep quality.

Factors influencing HRQoL

The multivariable linear regression analysis showed that female gender, the presence of comorbidities and the use of corticosteroids during the acute COVID-19, were associated with lower scores in SF-36, considering PCS and MCS, and EQ-VAS, which mean a worse perception of health status and HRQoL; only patients with previous hospitalization reported higher scores in MCS and the use of immunotherapy during the acute phase of infection was a significant predictor of lower scores in PCS (Table 3). Finally, in the univariable linear regression model, alterations in BAI, BDI II, and PSQI were associated with lower scores in SF-36 and EQ-VAS, in the subgroup of 265 patients in whom they were evaluated (Table 4).

Table 3

Factors associated with higher scores in SF-36 and in EQ-VAS, by multivariable linear regression.
	PCS				MCS				EQ-VAS
	beta	95%CI		p-value	beta	95%CI		p-value	beta	95%CI		p-value
Male vs female	16.64	12.71	20.57	< 0.001	15.53	11.73	19.33	< 0.001	10.28	7.12	13.45	< 0.001
Age, 10 years increase	-0.66	-2.45	1.12	0.466	1.38	-0.35	3.10	0.118	-0.32	-1.76	1.12	0.662
Number of comorbidities
1	-7.99	-12.75	-3.24	0.001	-4.99	-9.59	-0.39	0.033	-4.79	-8.62	-0.95	0.015
2	-12.90	-21.03	-4.77	0.002	-9.91	-17.77	-2.05	0.014	-12.18	-18.74	-5.63	< 0.001
≥ 3	-27.63	-38.76	-16.50	< 0.001	-23.78	-34.54	-13.02	< 0.001	-17.13	-26.10	-8.16	< 0.001
Months from the acute phase	0.21	-0.06	0.48	0.125	0.03	-0.23	0.29	0.817	0.14	-0.08	0.36	0.204
Previous hospitalization	2.50	-2.55	7.55	0.331	5.67	0.80	10.55	0.023	0.62	-3.44	4.69	0.764
Treatment in the acute phase
corticosteroids	-10.18	-15.17	-5.18	< 0.001	-6.16	-10.99	-1.33	0.012	-5.55	-9.58	-1.53	0.007
remdesivir	3.89	-1.96	9.74	0.192	3.67	-1.99	9.32	0.203	3.14	-1.57	7.85	0.191
immunotherapy	-16.11	-31.60	-0.62	0.042	-9.26	-24.24	5.72	0.225	-11.14	-23.62	1.34	0.080
heparin	-1.24	-6.82	4.33	0.661	-4.80	-10.19	0.59	0.081	2.76	-1.74	7.25	0.228
NIV	1.14	-4.63	6.90	0.699	0.69	-4.88	6.27	0.808	-1.20	-5.85	3.44	0.611
SF-36 the Short-Form 36-item questionnaire, PCS physical components score of the SF-36, MCS mental components score of the SF-36, EQ-VAS Visual Analogue Scale score of the EQ-5D, CI confidence interval, NIV noninvasive ventilation.

Table 4

Association between alterations in BAI, BDI-II and PSQI, and higher scores in SF-36 and EQ-VAS, by univariable linear regression.
	PCS				MCS				EQ-VAS
	beta	95%CI		p-value	beta	95%CI		p-value	beta	95%CI		p-value
BAI*	-0.84	-1.04	-0.65	< 0.001	-0.93	-1.11	-0.75	< 0.001	-0.59	-0.74	-0.44	< 0.001
BDI-II*	-1.10	-1.32	-0.88	< 0.001	-1.22	-1.42	-1.01	< 0.001	-0.74	-0.91	-0.57	< 0.001
PSQI*	-0.29	-0.50	-0.08	0.007	-0.22	-0.43	-0.01	0.037	-0.24	-0.39	-0.08	0.004
PCS physical components score of the SF-36, MCS mental components score of the Short-Form 36-item questionnaire, EQ-VAS Visual Analogue Scale score of the EQ-5D, CI confidence interval, BAI the Beck Anxiety Inventory, BDI-II the Beck Depression Inventory, PSQI the Pittsburgh Sleep Quality Index. *evaluated in a subgroup of 265 participants.

Our study involved a large number of patients from Italy who were systematically assessed for neuropsychological signs and symptoms at three timepoints after COVID-19, including a high proportion of patients without previous hospitalization, followed up to more than one year after the acute infection. Patients reported a significantly worse perception of physical and mental health status compared to the Italian normative group, and it remained stable over time, even one year after the acute infection. Other Italian studies assessing HRQoL through the same instruments (SF-36 and EQ-5D), were mainly focused on previously hospitalized patients evaluated not more than six months after COVID-19 [25–29]. One of the key findings of our study was the evidence of a persistent poor health status perception in the post-COVID-19 period. Similarly to previous studies done using SF-36, the most affected domains and the least affected domain were physical role and physical function, respectively [30–32]. When compared to the Italian normative group, both SF-36 (PCS and MCS) and EQ-VAS scores were lower in the study population. Interestingly, these ratings remained stable over the period of observation and, for the mental component of SF-36 and for EQ-VAS, they were even lower at the last evaluations. These findings emphasize that the impact on quality of life in the post-COVID-19 period, is not restricted to the first few months after the acute infection, but it should be considered a concern also at distance. Here, we have analyzed only the first evaluation of the participants, performed during their first referral at our outpatient clinic, even when it occurred several months after the infection, highlighting the necessity of a prolonged follow up. Even though, in this study, details on signs and symptoms of post-COVID-19 syndrome were not reported, the persistence of a poor health status perception could be directly related to the persistence of such symptoms, providing further evidences of the considerable effect of this condition on quality of life.

A recent systematic review [5] reported that the most common factors associated with lower levels of HRQoL, were female sex, older age, the presence of co-morbidities and developing critical illness. Similarly, a previous structured review [7], focusing on the impact of both acute and long COVID-19 on HRQoL, found that age, gender, severity of illness, comorbidity, income and educational level of the patients, were factors related to a worse perception of HRQoL. Our results were partially consistent with these findings. If the association of lower scores in EQ-VAS, MCS and PCS with female gender was strong and clear, the correlation to disease severity was indirect. In fact, a worse perception of HRQoL was observed mainly among patients with comorbidities and patients treated, during the acute phase, with corticosteroids and, only for PCS, immunotherapy. These features may be considered an indirect sign of disease severity, even though the use of noninvasive ventilation was not related to lower scores. Moreover, gender-based inequalities in health and in quality of life, have been frequently documented in several settings [33–35], probably due to the different exposure and vulnerability to specific determinants of health [33], and this phenomenon was particularly evident in the contest of COVID-19, considering that women seemed to suffer more frequently from long COVID symptoms [8, 36] with the consequent impact on the perception of health status and quality of life. As expected, considering the stable scores in SF-36 subscales during the entire period of observation, any association was found between HRQoL and distance from the acute phase. Finally, we did not observe any evidence of association with age, analyzed as a continuous variable, and we did not investigate income and educational level. Surprisingly, our study showed a better perception of MH in patients with previous hospitalization and it could be determined by the fact that patients managed at their own home, experienced the lockdown period and felt worried about the disease progression and potential complications, and insufficiently reassured about the symptoms they experienced. As a result, their perception of these symptoms could be exacerbated and their psychological sphere was possibly affected more the ones hospitalized. On the contrary, the hospitalization could offer more reassurance to the patients by inhibiting their anxious thoughts.

Regarding the presence of anxious-depressive symptoms and sleep disorders, we found that it was associated with a worse perception of health status and QoL. Such correlation is well documented also for other diseases, acute and chronic, and highlights the need to deal with neuropsychiatric symptoms during the post-COVID-19 period [37, 38].

Strengths of the present study were the prospective design and, as already underlined, the large sample size, including patients, with milder forms of COVID-19 and with a long follow up period, systematically evaluated at each visit; moreover, scales and questionnaires were face-to-face administered by health-professionals and neuropsychologists, decreasing the likelihood of misunderstanding and missing responses. The study had also some limitations. First of all, it was a single-center study without a control group of patients; furthermore, the absence of longitudinal data could limit the generalizability of the results; finally, for this analysis, we did not collect details on symptoms and we are aware of the potential selection bias due to the increased willingness of more symptomatic patients to take part in a follow-up study.

The findings of the present analysis confirm the high impact of post-COVID-19 syndrome on the perception of health status and quality of life, when compared to the Italian reference group, even more than one year after the acute phase of infection and also among patients without a previous hospitalization. Factors as female gender, presence of comorbidities and disease severity, seem to characterize patients at a higher risk and may be considered a target population for focused interventions. Moreover, it is likely to assume that the health status perception is also affected by stress factors related to the pandemic isolation condition and to the infectious event itself. Indeed, COVID-19 should be seen as a traumatic event. Further large-scale prospective longitudinal studies focusing on the ability to respond to the traumatic event, especially among those patients who experience the infection, are needed to obtain a thorough knowledge of peri- and post-traumatic implications of the SARS-CoV-2 pandemic and of the seriousness of the psychological distress on the world population. Finally, a systematic monitoring of Patient Reported Outcomes and quality of life is recommended to properly manage patients in the post-COVID-19 period, for whom a multidimensional patient care must be ensured by the health care system, coordinated by a dedicated long COVID service with multidisciplinary support.

Ethics approval and consent to participate

The study protocol (NeuroCovid Study, version 2.0, January 08, 2021) and the informed consent, were approved by the Ethical Committee of the National Institute for Infectious Diseases “Lazzaro Spallanzani” in Rome, Italy (approval number 265/2021). Written informed consent was obtained from all the participants.

Consent for publication

Not applicable.

Availability of data and materials

The raw data generated and/or analyzed within the present study are available in our institutional repository (rawdata.inmi.it), subject to registration. In the event of a malfunction of the application, the request can be sent directly by e-mail to the Library ([email protected]). No charge for granting access to data is required.

Competing interests

The authors declare that they have no competing interests for the present study.

Funding

This work was supported by INMI “Lazzaro Spallanzani” Ricerca Corrente Linea 1 on emerging and reemerging infections, funded by Italian Ministry of Health.

Authors’ contributions

Conceptualization: IM, GDD, CP, PL, AV, ACB; Methodology: IM, PL; Formal analysis: PL; Investigation: IM, AV, MC, VM, FB, PC, PM, MLG, AAb; Writing - original draft preparation: IM; Writing - review and editing: GDD, CP, PL, AV, ACB, MC, FB, MLG, AAn; Funding acquisition: EG, FV, AAn; Supervision: EG, FV, AAn.

Acknowledgements

The authors gratefully acknowledge all thestudy participants, doctors and nurses of the post-COVID-19 outpatient service at the National Institute for Infectious Diseases “Lazzaro Spallanzani” in Rome, Italy.

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No competing interests reported.

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What is the impact of post-COVID-19 syndrome on health-related quality of life and associated factors: a cross-sectional analysis

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Abstract

Background.

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Results.

Conclusions.

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Introduction

Methods

Study design and study population

Questionnaires

Neuropsychiatric symptom assessment

Statistical analyses

Results

Descriptive analysis

HRQoL assessment

Neuropsychiatric symptoms assessment

Factors influencing HRQoL

Discussion

Conclusions

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References

Additional Declarations

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