Access to affordable clean energy source as stipulated in UN SDG goal number 7 is important for the development and socio-economic well-being of people, the need for proper assessment of resources to achieve this goal is indisputable. The goal of this study is to assess the economic feasibility of utilizing organic fraction of Municipal Solid Wastes (MSWof) using a case study of 21 Local Government Areas (LGA) or Authority for Anambra State of Nigeria for waste to energy project. The quantity of organic fraction of MSW, energy recovery and optimum number of plants at the various LGAs was estimated. The result of the study indicates that about 198 tons maximum value of MSWof can be generated daily in Aguata LGA, with electric energy potential value of 545MW. The number of plants for the LGAs ranged from 10 to 50 and from 3 to 12 for small and medium scale plants. A large scale plant of about 50m3 can possibly be installed at all the LGAs, with a maximum of 4 plants in Idemili and Aguata LGA. The economic assessment based on Net Present Value (NPV) criteria shows poor economic feasibility for small scale plant, while NPV was positive for medium and large scale plants. The Internal Rate of Return (IRR) ranged from 0.32 to 0.94, with a general increase from small scale to large scale economic feasibility. It is suggested that the autonomy of the various LGAs in the country should serve as a major motivation in adopting bio-energy projects independently, and this study will serve as a decision toolkit in the appropriate scale to be adopted.