The rapid development of e-commerce has greatly promoted the development of the modern logistics industry. The application level of e-commerce and the application status of modern logistics largely determine the development of regional economic structure in a region. Under this circumstance, it is particularly important to comprehensively strengthen the research and analysis of the impact of e-commerce and modern logistics on the regional economic structure and scope, and promote the coordinated development between each other. As one of the most developed regions in China, the Yangtze River Delta region has achieved certain achievements in the development of regional logistics industry and e-commerce, and plays an important role in the process of regional integration in the Yangtze River Delta. Therefore, this paper takes the Yangtze River Delta as the research object, and empirically analyses the development status of the logistics industry and e-commerce in the Yangtze River Delta region and its contribution to regional economic growth. On this basis, it puts forward countermeasures to further increase the contribution of the logistics industry and e-commerce in the Yangtze River Delta region to economic growth. This will provide a reference for the construction of a coordinated regional logistics-e-commerce system and the realization of regional economic integration in the Yangtze River Delta region.