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Research article
Haibin Xia
Wuhan University
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2550-1146
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: This study aimed to investigate clinical characteristics and early soft tissues response to zirconium oxide (Zr) and titanium (Ti) abutments in dogs.
Methods: Eight implants-four at each hemi-mandible were inserted after bilateral mandibular third and fourth premolars and first molars extraction. Two Zr and two Ti healing abutments were connected in each unilateral mandible 8 weeks later. The ligation method was used to make peri-implant mucositis model. The twenty-four abutments were divided into four groups, Zr and Ti healing abutments with ligation (ZrL, TiL) and non-ligation (ZrN, TiN) groups. Clinical index, peri-implant crevicular fluid (PICF) and inflammatory cytokines (TNF-α and IL-1β), soft tissue responses were tested. Two-way analysis of variance was used to analyze the data.
Results: The results showed that the clinical index were similar around Zr and Ti healing abutments. PICF in ZrL and TiL groups were significantly higher than those in ZrN and TiN groups. Immunohistochemistry demonstrated inflammatory cells were non-significant differences.
Conclusion: These data indicate soft tissue responses to Zr healing abutments with peri-implant mucositis was comparable to those to Ti healing abutments in vivo, and can provide theoretical foundation for Zr’s clinical application.
Keywords
peri-implant crevicular fluid, healing abutment, ligation, zirconium oxide, titanium
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CURRENT STATUS: Under Review
Version 1
Posted 19 Feb, 2021
No community comments so far
Review #4 received
Received 30 Apr, 2021
Review #3 received
Received 30 Apr, 2021
Editorial decision: Major revision
On 30 Apr, 2021
Reviewer #4 agreed
On 14 Apr, 2021
Review #2 received
Received 20 Mar, 2021
Reviewer #3 agreed
On 05 Mar, 2021
Reviewer #2 agreed
On 05 Mar, 2021
Review #1 received
Received 12 Feb, 2021
Reviewer #1 agreed
On 11 Feb, 2021
Editor assigned
On 09 Feb, 2021
Reviewers invited
Invitations sent on 09 Feb, 2021
Submission checks complete
On 09 Feb, 2021
Editor invited
On 09 Feb, 2021
First submitted
On 19 Jan, 2021
Metrics
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PDF Downloads: ...
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Subject Areas
Dentistry
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This preprint is under consideration at BMC Oral Health. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Haibin Xia
Wuhan University
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2550-1146
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 19 Feb, 2021
No community comments so far
Review #4 received
Received 30 Apr, 2021
Review #3 received
Received 30 Apr, 2021
Editorial decision: Major revision
On 30 Apr, 2021
Reviewer #4 agreed
On 14 Apr, 2021
Review #2 received
Received 20 Mar, 2021
Reviewer #3 agreed
On 05 Mar, 2021
Reviewer #2 agreed
On 05 Mar, 2021
Review #1 received
Received 12 Feb, 2021
Reviewer #1 agreed
On 11 Feb, 2021
Editor assigned
On 09 Feb, 2021
Reviewers invited
Invitations sent on 09 Feb, 2021
Submission checks complete
On 09 Feb, 2021
Editor invited
On 09 Feb, 2021
First submitted
On 19 Jan, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Dentistry
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: This study aimed to investigate clinical characteristics and early soft tissues response to zirconium oxide (Zr) and titanium (Ti) abutments in dogs.
Methods: Eight implants-four at each hemi-mandible were inserted after bilateral mandibular third and fourth premolars and first molars extraction. Two Zr and two Ti healing abutments were connected in each unilateral mandible 8 weeks later. The ligation method was used to make peri-implant mucositis model. The twenty-four abutments were divided into four groups, Zr and Ti healing abutments with ligation (ZrL, TiL) and non-ligation (ZrN, TiN) groups. Clinical index, peri-implant crevicular fluid (PICF) and inflammatory cytokines (TNF-α and IL-1β), soft tissue responses were tested. Two-way analysis of variance was used to analyze the data.
Results: The results showed that the clinical index were similar around Zr and Ti healing abutments. PICF in ZrL and TiL groups were significantly higher than those in ZrN and TiN groups. Immunohistochemistry demonstrated inflammatory cells were non-significant differences.
Conclusion: These data indicate soft tissue responses to Zr healing abutments with peri-implant mucositis was comparable to those to Ti healing abutments in vivo, and can provide theoretical foundation for Zr’s clinical application.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
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