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Research
Yong Xie
First Affiliated Hospital of Nanchang University
Corresponding Author
ORCiD: https://orcid.org/0000-0002-5290-5579
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Gastrointestinal stromal tumors (GISTs) of the stomach are the most common GISTs. The risk, incidence and outcome of cancer are different between the sexes. Whether gender is related to the prognosis of gastric stromal tumors is unclear. Therefore, this study aims to explore the relationship between gender and gastric GIST prognosis.
Methods: Data from gastric GIST patients were collected from the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching (PSM) was performed to reduce confounding factors, and the clinicopathological features and prognosis of GIST patients were comprehensively evaluated.
Results: There were 512 male patients and 538 female patients with gastric GIST. The gender of gastric GIST patients was associated with marital status, surgical treatment, tumor size, and mitotic index (P < 0.05). The Kaplan-Meier analysis and log-rank test revealed that male patients had a higher mortality rate than female patients (P = 0.0024). After matching all the potential confounding factors, the survival of the female gastric GIST patients was better than that of the male gastric GIST patients (P = 0.042). Cox regression analysis revealed that gender was an independent risk factor for overall survival. The risk of death was higher for males than for females (HR: 1.677, 95% CI: 1.150-2.444, P = 0.007).
Conclusion: Gender could be a prognostic factor for gastric GIST survival, and male patients had a higher risk of death.
Keywords
gender, gastric gastrointestinal stromal tumor, propensity score matching
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CURRENT STATUS: Published
View the published article at Biology of Sex Differences.
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Posted 29 Jun, 2020
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Review #2 received
Received 13 Jul, 2020
Editorial decision: Accept
On 13 Jul, 2020
Review #1 received
Received 03 Jul, 2020
Reviewer #2 agreed
On 30 Jun, 2020
Reviewer #1 agreed
On 29 Jun, 2020
Reviewers invited
Invitations sent on 28 Jun, 2020
Editor assigned
On 25 Jun, 2020
Submission checks complete
On 24 Jun, 2020
Editor invited
On 24 Jun, 2020
No comments provided
Review #2 received
Received 04 Jun, 2020
Editorial decision: Major Revision
On 04 Jun, 2020
Reviewer #2 agreed
On 29 May, 2020
Review #1 received
Received 21 May, 2020
Reviewer #1 agreed
On 07 May, 2020
Reviewers invited
Invitations sent on 06 May, 2020
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On 21 Apr, 2020
Submission checks complete
On 20 Apr, 2020
Editor invited
On 20 Apr, 2020
First submitted
On 19 Apr, 2020
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Subject Areas
Gastroenterology & Hepatology
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A new preprint design is coming!
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See the published version of this preprint at Biology of Sex Differences.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Yong Xie
First Affiliated Hospital of Nanchang University
Corresponding Author
ORCiD: https://orcid.org/0000-0002-5290-5579
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Biology of Sex Differences.
Version 2
Posted 29 Jun, 2020
No community comments so far
Review #2 received
Received 13 Jul, 2020
Editorial decision: Accept
On 13 Jul, 2020
Review #1 received
Received 03 Jul, 2020
Reviewer #2 agreed
On 30 Jun, 2020
Reviewer #1 agreed
On 29 Jun, 2020
Reviewers invited
Invitations sent on 28 Jun, 2020
Editor assigned
On 25 Jun, 2020
Submission checks complete
On 24 Jun, 2020
Editor invited
On 24 Jun, 2020
No comments provided
Review #2 received
Received 04 Jun, 2020
Editorial decision: Major Revision
On 04 Jun, 2020
Reviewer #2 agreed
On 29 May, 2020
Review #1 received
Received 21 May, 2020
Reviewer #1 agreed
On 07 May, 2020
Reviewers invited
Invitations sent on 06 May, 2020
Editor assigned
On 21 Apr, 2020
Submission checks complete
On 20 Apr, 2020
Editor invited
On 20 Apr, 2020
First submitted
On 19 Apr, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Gastroenterology & Hepatology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Biology of Sex Differences.
Background: Gastrointestinal stromal tumors (GISTs) of the stomach are the most common GISTs. The risk, incidence and outcome of cancer are different between the sexes. Whether gender is related to the prognosis of gastric stromal tumors is unclear. Therefore, this study aims to explore the relationship between gender and gastric GIST prognosis.
Methods: Data from gastric GIST patients were collected from the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching (PSM) was performed to reduce confounding factors, and the clinicopathological features and prognosis of GIST patients were comprehensively evaluated.
Results: There were 512 male patients and 538 female patients with gastric GIST. The gender of gastric GIST patients was associated with marital status, surgical treatment, tumor size, and mitotic index (P < 0.05). The Kaplan-Meier analysis and log-rank test revealed that male patients had a higher mortality rate than female patients (P = 0.0024). After matching all the potential confounding factors, the survival of the female gastric GIST patients was better than that of the male gastric GIST patients (P = 0.042). Cox regression analysis revealed that gender was an independent risk factor for overall survival. The risk of death was higher for males than for females (HR: 1.677, 95% CI: 1.150-2.444, P = 0.007).
Conclusion: Gender could be a prognostic factor for gastric GIST survival, and male patients had a higher risk of death.
Figure 1
Figure 2
Figure 3
This is a list of supplementary files associated with this preprint. Click to download.
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