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Research article
Farzad Hadaegh
Prevention of Metabolic Research Disorder Center, Research institute for Endocrine Disorder, Shahid Beheshti University of Medical Science.
Corresponding Author
ORCiD: https://orcid.org/0000-0002-8935-2744
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Background: Most previous studies conducted in non-Middle Eastern populations have suggested that an increase in the number of parity/live birth(s) leads to cardiovascular disease (CVD) development, although their findings were inconclusive on this issue for both sexes. Biologic and socioeconomic pathways were suggested to explain this association. We studied this issue among urban Iranian men and women.
Methods: In this population-based cohort study, which included 3929 women and 2571 men aged ≥ 30 years, data for the number of parity/live birth(s) were obtained by a standard questionnaire. Participants were then annually followed for CVD events. Multivariate Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the number of parity/live birth(s) and other traditional CVD risk factors.
Results: During more than 15 years of follow-up, 456 and 524 CVD events have occurred among women and men, respectively. Among women, a J-shaped association was found between the number of live births and incident CVD with the lowest risk for women with two live births. Among women in multivariate analyses, each unit increase in parity had a HR of 1.05 (CI: 1.01-1.10), and having ≥4 parity was associated with a HR of 1.86 (0.97-3.56, p-value=0.061). Among men, in comparison with participants who had 1 child, multivariate HRs of having 2, 3, and ≥4 children were 1.97 (1.24-3.12), 2.08 (1.31-3.31), and 2.08 (1.30-3.34), respectively.
Conclusion: To the best of our knowledge, the current study is the first report on this issue in the Middle East and North Africa region, a region with a high burden of CVD. It can now be suggested that the number of parity/live birth(s) is linked to CVD among the Iranian population, with this issue being more prominent among men. Further research is needed to support our results and clarify the pathways between the number of parity/live birth(s) and CVD development among Iranian populations by considering potential risk factors, especially psycho-socio-economic risk factors.
Keywords
Cardiovascular disease, Parity, Live birth, The Tehran Lipid and Glucose Study
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CURRENT STATUS: Published
View the published article at BMC Pregnancy and Childbirth.
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On 17 Dec, 2020
Editorial decision: Accept
On 14 Dec, 2020
Version 3
Posted 08 Dec, 2020
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Editorial decision: Minor revision
On 02 Dec, 2020
Editor assigned
On 24 Nov, 2020
Submission checks complete
On 24 Nov, 2020
Editor invited
On 24 Nov, 2020
No comments provided
Editorial decision: Minor revision
On 14 Nov, 2020
Review #1 received
Received 25 Oct, 2020
Editor assigned
On 19 Oct, 2020
Reviewers invited
Invitations sent on 19 Oct, 2020
Reviewer #1 agreed
On 19 Oct, 2020
Submission checks complete
On 18 Oct, 2020
Editor invited
On 18 Oct, 2020
No comments provided
Editorial decision: Major revision
On 16 Sep, 2020
Review #1 received
Received 22 Jun, 2020
Reviewer #1 agreed
On 02 Jun, 2020
Reviewers invited
Invitations sent on 14 May, 2020
Editor assigned
On 23 Apr, 2020
Submission checks complete
On 22 Apr, 2020
Editor invited
On 22 Apr, 2020
First submitted
On 21 Apr, 2020
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A new preprint design is coming!
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See the published version of this preprint at BMC Pregnancy and Childbirth.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Farzad Hadaegh
Prevention of Metabolic Research Disorder Center, Research institute for Endocrine Disorder, Shahid Beheshti University of Medical Science.
Corresponding Author
ORCiD: https://orcid.org/0000-0002-8935-2744
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Pregnancy and Childbirth.
No community comments so far
Submission checks complete
On 17 Dec, 2020
Editorial decision: Accept
On 14 Dec, 2020
Version 3
Posted 08 Dec, 2020
No comments provided
Editorial decision: Minor revision
On 02 Dec, 2020
Editor assigned
On 24 Nov, 2020
Submission checks complete
On 24 Nov, 2020
Editor invited
On 24 Nov, 2020
No comments provided
Editorial decision: Minor revision
On 14 Nov, 2020
Review #1 received
Received 25 Oct, 2020
Editor assigned
On 19 Oct, 2020
Reviewers invited
Invitations sent on 19 Oct, 2020
Reviewer #1 agreed
On 19 Oct, 2020
Submission checks complete
On 18 Oct, 2020
Editor invited
On 18 Oct, 2020
No comments provided
Editorial decision: Major revision
On 16 Sep, 2020
Review #1 received
Received 22 Jun, 2020
Reviewer #1 agreed
On 02 Jun, 2020
Reviewers invited
Invitations sent on 14 May, 2020
Editor assigned
On 23 Apr, 2020
Submission checks complete
On 22 Apr, 2020
Editor invited
On 22 Apr, 2020
First submitted
On 21 Apr, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Pregnancy and Childbirth.
Background: Most previous studies conducted in non-Middle Eastern populations have suggested that an increase in the number of parity/live birth(s) leads to cardiovascular disease (CVD) development, although their findings were inconclusive on this issue for both sexes. Biologic and socioeconomic pathways were suggested to explain this association. We studied this issue among urban Iranian men and women.
Methods: In this population-based cohort study, which included 3929 women and 2571 men aged ≥ 30 years, data for the number of parity/live birth(s) were obtained by a standard questionnaire. Participants were then annually followed for CVD events. Multivariate Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the number of parity/live birth(s) and other traditional CVD risk factors.
Results: During more than 15 years of follow-up, 456 and 524 CVD events have occurred among women and men, respectively. Among women, a J-shaped association was found between the number of live births and incident CVD with the lowest risk for women with two live births. Among women in multivariate analyses, each unit increase in parity had a HR of 1.05 (CI: 1.01-1.10), and having ≥4 parity was associated with a HR of 1.86 (0.97-3.56, p-value=0.061). Among men, in comparison with participants who had 1 child, multivariate HRs of having 2, 3, and ≥4 children were 1.97 (1.24-3.12), 2.08 (1.31-3.31), and 2.08 (1.30-3.34), respectively.
Conclusion: To the best of our knowledge, the current study is the first report on this issue in the Middle East and North Africa region, a region with a high burden of CVD. It can now be suggested that the number of parity/live birth(s) is linked to CVD among the Iranian population, with this issue being more prominent among men. Further research is needed to support our results and clarify the pathways between the number of parity/live birth(s) and CVD development among Iranian populations by considering potential risk factors, especially psycho-socio-economic risk factors.
Figure 1
This is a list of supplementary files associated with this preprint. Click to download.
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