This preprint is under consideration at Journal of Ovarian Research. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Extended doxycycline treatment versus salpingectomy in the management of patients of hydrosalpinx undergoing IVF-ET
Usama Fouda
Cairo University
Corresponding Author
ORCiD: https://orcid.org/0000-0002-5002-4188
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: The aim of this study was to determine whether the treatment with doxycycline before and after oocyte retrieval is as effective as salpingectomy in minimizing the detrimental effect of hydrosalpinx on the outcomes of IVF-ET.
Methods: A retrospective analysis was done for the outcomes of the IVF-ET cycles of patients with hydrosalpinx who underwent laparoscopic salpingectomy prior to IVF cycle ( n = 260 ) or were treated with extended doxycycline treatment during the IVF cycle (n = 45).In doxycycline group, doxycycline (100 mg twice daily ) was started one week before anticipated oocyte retrieval and was continued for one week after oocyte retrieval. In salpingectomy group, the mesosalpinx was coagulated as close as possible to the fallopian tube.
Results: The implantation, clinical pregnancy, ongoing pregnancy and live birth rates were significantly higher in the salpingectomy group ( 20.87 % Vs. 9.91%, P value =0.007, 44.62% Vs. 20% P value = 0.002, 39.62% Vs. 17.78%,P value = 0.005 and 37.31% Vs. 15.56% P value = 0.005 respectively).
Conclusion: Salpingectomy is more effective than extended doxycycline treatment in improving the outcomes of IVF-ET in patients with hydrosalpinx undergoing IVF-ET. Further, larger well designed randomized controlled trials should be conducted to confirm the findings of this study.
Keywords
Salpingectomy , Doxycycline, Hydrosalpinx, IVF-ET, Infertility
2 comments flagged for moderation
If you posted a comment and think it was mistakenly removed, please contact customer support at [email protected].
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 2
Posted 27 May, 2020
No community comments so far
Review #2 received
Received 21 May, 2020
Reviewer #2 agreed
On 20 May, 2020
Editor assigned
On 18 May, 2020
Reviewers invited
Invitations sent on 18 May, 2020
Reviewer #1 agreed
On 18 May, 2020
Review #1 received
Received 18 May, 2020
Submission checks complete
On 17 May, 2020
Editor invited
On 17 May, 2020
No comments provided
Editorial decision: Major revision
On 05 May, 2020
Review #2 received
Received 22 Apr, 2020
Reviewers invited
Invitations sent on 22 Apr, 2020
Reviewer #1 agreed
On 22 Apr, 2020
Reviewer #2 agreed
On 22 Apr, 2020
Review #1 received
Received 22 Apr, 2020
Editor assigned
On 21 Apr, 2020
First submitted
On 20 Apr, 2020
Submission checks complete
On 20 Apr, 2020
Editor invited
On 20 Apr, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Learn more about our company.
This preprint is under consideration at Journal of Ovarian Research. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Extended doxycycline treatment versus salpingectomy in the management of patients of hydrosalpinx undergoing IVF-ET
Usama Fouda
Cairo University
Corresponding Author
ORCiD: https://orcid.org/0000-0002-5002-4188
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 2
Posted 27 May, 2020
No community comments so far
Review #2 received
Received 21 May, 2020
Reviewer #2 agreed
On 20 May, 2020
Editor assigned
On 18 May, 2020
Reviewers invited
Invitations sent on 18 May, 2020
Reviewer #1 agreed
On 18 May, 2020
Review #1 received
Received 18 May, 2020
Submission checks complete
On 17 May, 2020
Editor invited
On 17 May, 2020
No comments provided
Editorial decision: Major revision
On 05 May, 2020
Review #2 received
Received 22 Apr, 2020
Reviewers invited
Invitations sent on 22 Apr, 2020
Reviewer #1 agreed
On 22 Apr, 2020
Reviewer #2 agreed
On 22 Apr, 2020
Review #1 received
Received 22 Apr, 2020
Editor assigned
On 21 Apr, 2020
First submitted
On 20 Apr, 2020
Submission checks complete
On 20 Apr, 2020
Editor invited
On 20 Apr, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: The aim of this study was to determine whether the treatment with doxycycline before and after oocyte retrieval is as effective as salpingectomy in minimizing the detrimental effect of hydrosalpinx on the outcomes of IVF-ET.
Methods: A retrospective analysis was done for the outcomes of the IVF-ET cycles of patients with hydrosalpinx who underwent laparoscopic salpingectomy prior to IVF cycle ( n = 260 ) or were treated with extended doxycycline treatment during the IVF cycle (n = 45).In doxycycline group, doxycycline (100 mg twice daily ) was started one week before anticipated oocyte retrieval and was continued for one week after oocyte retrieval. In salpingectomy group, the mesosalpinx was coagulated as close as possible to the fallopian tube.
Results: The implantation, clinical pregnancy, ongoing pregnancy and live birth rates were significantly higher in the salpingectomy group ( 20.87 % Vs. 9.91%, P value =0.007, 44.62% Vs. 20% P value = 0.002, 39.62% Vs. 17.78%,P value = 0.005 and 37.31% Vs. 15.56% P value = 0.005 respectively).
Conclusion: Salpingectomy is more effective than extended doxycycline treatment in improving the outcomes of IVF-ET in patients with hydrosalpinx undergoing IVF-ET. Further, larger well designed randomized controlled trials should be conducted to confirm the findings of this study.