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Research Article
Lei Yu
Renal Division, Inner Mongolia People's Hospital, Hohhot, Inner Mongolia 010017.
Corresponding Author
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Background
Chronic kidney disease (CKD) is associated with Immune deficiency. T lymphocytes are significant components of the adaptive immune system. Previous studies have found dysfunction of T lymphocytes in patients with CKD,but the changing trend of the absolute number of T lymphocytes and the relationship with infection has been still unclear in CKD.
Methods
We collected 447 patients with CKD, tested the absolute counts of T lymphocyte subsets, explored the relationship between the absolute count of T lymphocytes and renal function, and explored these impacts on infection.
Results
absolute counts of T lymphocyte gradually decrease as CKD progresses. The patients with infection demonstrated fewer T lymphocyte cells compared with non-infected patients. CD4+ (cluster of differentiation 4) T lymphocytes are closely related to infection and CD4+ T < 469 cells/µl has a certain value in predicting infection in patients with CKD.
Conclusion
With the gradual decline of renal function in CKD patients, the level of T lymphocytes gradually decreased and the risk of infection gradually increased. The CD4+T absolute count has a specific predictive power for infection in patients with chronic kidney disease. Our results suggest a new feasible strategy for preventing infections in CKD patients.
Figure 1
Figure 2
Figure 3
No competing interests reported.
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research Article
Lei Yu
Renal Division, Inner Mongolia People's Hospital, Hohhot, Inner Mongolia 010017.
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 25 Feb, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Urology & Nephrology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Chronic kidney disease (CKD) is associated with Immune deficiency. T lymphocytes are significant components of the adaptive immune system. Previous studies have found dysfunction of T lymphocytes in patients with CKD,but the changing trend of the absolute number of T lymphocytes and the relationship with infection has been still unclear in CKD.
Methods
We collected 447 patients with CKD, tested the absolute counts of T lymphocyte subsets, explored the relationship between the absolute count of T lymphocytes and renal function, and explored these impacts on infection.
Results
absolute counts of T lymphocyte gradually decrease as CKD progresses. The patients with infection demonstrated fewer T lymphocyte cells compared with non-infected patients. CD4+ (cluster of differentiation 4) T lymphocytes are closely related to infection and CD4+ T < 469 cells/µl has a certain value in predicting infection in patients with CKD.
Conclusion
With the gradual decline of renal function in CKD patients, the level of T lymphocytes gradually decreased and the risk of infection gradually increased. The CD4+T absolute count has a specific predictive power for infection in patients with chronic kidney disease. Our results suggest a new feasible strategy for preventing infections in CKD patients.
Figure 1
Figure 2
Figure 3
No competing interests reported.
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