This preprint is under consideration at Allergy, Asthma & Clinical Immunology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Case report
David X. Gao
University of Illinois College of Medicine at Peoria
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1314-8800
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: common variable immunodeficiency (CVID) is a primary immunodeficiency disorder associated with a broad symptom presentation that is still being characterized. We report a rare case of recurrent mycoplasma skin abscesses in a patient with a history of autoimmune disorders and prolonged mycoplasma pneumonia who was diagnosed with CVID.
Case presentation: a 34-year-old woman presented with a history of recurrent abscesses previously confirmed positive for Mycoplasma pneumoniae. Her past medical history of recurrent mycoplasma abscesses, prolonged mycoplasma pneumonia, and autoimmune disorders (mixed connective tissue disease and immune thrombocytopenia) raised suspicion of CVID. Workup included negative anti-mycoplasma antibody titers, hypogammaglobulinemia, and negative anti-pneumococcal antibody titers despite prior vaccination, solidifying the diagnosis of CVID. The patient was discharged on antibiotic and intravenous immunoglobulin therapy with improvement and now follows allergy and immunology long-term for treatment.
Conclusions: her diagnostic history underscores the importance of considering the various criteria of CVID for diagnosis, and her unique presentation of M. pneumoniae skin abscesses highlights the broad sequelae patients with CVID can manifest.
Keywords
common variable immunodeficiency, mycoplasma
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CURRENT STATUS: Under Revision
Version 1
Posted 26 Feb, 2021
No community comments so far
Editorial decision: Major revision
On 16 May, 2021
Review #2 received
Received 14 May, 2021
Reviewer #3 agreed
On 02 May, 2021
Review #3 received
Received 02 May, 2021
Reviewer #2 agreed
On 01 May, 2021
Review #1 received
Received 06 Apr, 2021
Reviewer #1 agreed
On 27 Feb, 2021
Reviews received
Received 27 Feb, 2021
Reviewers invited
Invitations sent on 20 Feb, 2021
Editor assigned
On 14 Feb, 2021
Submission checks complete
On 14 Feb, 2021
Editor invited
On 14 Feb, 2021
First submitted
On 14 Feb, 2021
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This preprint is under consideration at Allergy, Asthma & Clinical Immunology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Case report
David X. Gao
University of Illinois College of Medicine at Peoria
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1314-8800
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Revision
Version 1
Posted 26 Feb, 2021
No community comments so far
Editorial decision: Major revision
On 16 May, 2021
Review #2 received
Received 14 May, 2021
Reviewer #3 agreed
On 02 May, 2021
Review #3 received
Received 02 May, 2021
Reviewer #2 agreed
On 01 May, 2021
Review #1 received
Received 06 Apr, 2021
Reviewer #1 agreed
On 27 Feb, 2021
Reviews received
Received 27 Feb, 2021
Reviewers invited
Invitations sent on 20 Feb, 2021
Editor assigned
On 14 Feb, 2021
Submission checks complete
On 14 Feb, 2021
Editor invited
On 14 Feb, 2021
First submitted
On 14 Feb, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: common variable immunodeficiency (CVID) is a primary immunodeficiency disorder associated with a broad symptom presentation that is still being characterized. We report a rare case of recurrent mycoplasma skin abscesses in a patient with a history of autoimmune disorders and prolonged mycoplasma pneumonia who was diagnosed with CVID.
Case presentation: a 34-year-old woman presented with a history of recurrent abscesses previously confirmed positive for Mycoplasma pneumoniae. Her past medical history of recurrent mycoplasma abscesses, prolonged mycoplasma pneumonia, and autoimmune disorders (mixed connective tissue disease and immune thrombocytopenia) raised suspicion of CVID. Workup included negative anti-mycoplasma antibody titers, hypogammaglobulinemia, and negative anti-pneumococcal antibody titers despite prior vaccination, solidifying the diagnosis of CVID. The patient was discharged on antibiotic and intravenous immunoglobulin therapy with improvement and now follows allergy and immunology long-term for treatment.
Conclusions: her diagnostic history underscores the importance of considering the various criteria of CVID for diagnosis, and her unique presentation of M. pneumoniae skin abscesses highlights the broad sequelae patients with CVID can manifest.
Figure 1
Figure 2
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