Congenital hepatic hemangioma: An unusual case report of pulmonary hypertension

DOI: https://doi.org/10.21203/rs.3.rs-2457894/v1

Abstract

Background: Pulmonary hypertension (PH) in a newborns is a rare but serious condition that often requires immediate intervention and quick diagnosis of the correct etiologyto prevent mortality. Congenital hepatic hemangioma (CHH) is an example of an extrathoracic etiology of PH.

Case presentation: Herein, we report the case of a newborn with a giant liver hemangioma, who presented with an early onset of PH and was successfully treated with intra-arterial embolization.

Conclusions: This case illustrates the importance of suspicion and prompt evaluation of CHH and related systemic arteriovenous shunts among infants with unexplained PH.

Background

The etiologies of pulmonary hypertension(PH) are very diverse and include congenital heart disease(CHD), parenchymal lung diseases, pulmonary hypoplasia, congenital diaphragmatic hernia, sepsis, perinatal depression, and in utero medication exposure (selective serotonin reuptake inhibitor and nonsteroidal anti-inflammatory)[1]. Although intrathoracic disease and congenital heart defects are the most common etiologies, extrathoracic causes and non-cardiac causes must be considered[2]. Congenital hepatic hemangioma (CHH) is an example of a potentially fatal prognosis if not positively managed. Here, we report the case of a newborn who presented with tachypnea and tachycardia. It has been established that the newborn’s symptoms were due to PAH secondary to CHH.

Case presentation

A 23-year-old primigravida was referred to our hospital at 37 weeks of gestation because the B ultrasound showed that the fetal right atrium was enlarged, the lung-to-host ratio was 0.69, and the hepatic vein was widened. Maternal history was unremarkable, with the routine first- and second-trimester ultrasound scans reported as normal. At 37 + 2 weeks, an elective cesarean section was performed, delivering a female infant weighing 2750 g and with Apgar scores of 9 and 10 at 1 and 5 min, respectively. On the first postnatal day, the physical examination revealed tachypnea and tachycardia. The breath sounds were equal bilaterally. Cardiovascular examination revealed a grade 3/6 holosystolic murmur best heard at the left parasternal second intercostal border, with no thrill. The liver was tangible 3 cm below the right costal margin. No vascular malformations were noted over the skin and no splenomegaly was not observed.

A complete blood count revealed mild anemia. Evaluation of cardiac function revealed markedly elevated (33198 pg/mL) B-natriuretic peptide (BNP). Liver function tests were all within normal limits apart from decreased total protein (45.9 g/L, normal range: 49–71 g/L) and albumin (30.4 g/L, normal range: 35–50 g/L). There was no evidence of renal function dysfunction (creatinine: 63µmol/L; blood urea nitrogen: 6.5 mmol/L). Serum α-fetoprotein level (> 3000ng/ml) was above normal limits for the neonatal period. There was no evidence of hepatitis B or A virus infection.

We performed echocardiography, which revealed a heart with a maximum tricuspid regurgitation jet velocity of 4.7 m/s (estimated pulmonary artery systolic pressure of 88 mm Hg), atrial septal defect (ASD) 4.9 mm (bidirectional shunt), patent ductus arteriosus (PDA) 3.0 mm (bidirectional shunt), dilated right atrium and right ventricle, indicative of PH. Chest radiograph revealed an enlarged cardiac silhouette with increased pulmonary vascularity without pneumonia. Given the presence of hepatomegaly, an abdominal ultrasound (US) (Fig. 1) was performed, which revealed cavernous transformation in the liver with the intralesional massive turbulent vascular flow. Surprisingly, the portal vein was slightly thickened, and the left, middle, and right hepatic veins were significantly dilated.

Abdominal CT scan(Fig. 2) revealed an enlarged liver and multiple patchy hypodense foci in the liver. After contrast medium injection, the lesions showed an enhanced signal intensity. There are multiple arteries in the lesion that were connected to the portal and hepatic veins respectively. The thickened right internal thoracic artery was connected to the left branch of the portal vein.

The patient was diagnosed with PH secondary to CHH due to the enhanced pulmonary blood flow from the congenital hepatic vascular shunt. The newborn was treated with diuretics and fluid restriction. Serial echocardiograms were performed to follow the improvement in PH. However, on serial echocardiograms, pulmonary arterial pressure showed an increasing trend (88 mmHg-110 mmHg-117 mmHg) (Fig. 3). At this crucial juncture, the benefits and risks of arterial angiography and embolization were considered, and a decision was made to embolize of the major vascular feeders. Informed consent was acquired from the parents with the understanding that the major indications for this procedure were PH and CHH at 20 days after birth. Preoperative preparation included an electrocardiogram, an abrosia diet, and total parenteral nutrition.

Under general anesthesia, the innominate artery was accessed under ultrasonic guidance, and a 4F elbowed catheter was advanced into the right internal thoracic artery to the anterior bifurcation of the liver tumor vessels. Gelatin sponge particles were slowly from the right internal thoracic artery to the blind end(Figs. 4). A 4F straight flush catheter was advanced into the proper hepatic artery via femoral arterial-celiac trunk access. After angiography, digital subtraction angiography (DSA) was used to guide selective catheterization and gelatin sponge embolization of the right and left hepatic arteries. Branches at all levels were embolized (Figs. 5). The patient was transferred to the neonatal intensive care unit after surgery.

During the postoperative recovery stage, the newborn gradually stabilized. Abdominal scans revealed a progressively smaller hepatic mass. On serial echocardiograms, pulmonary arterial pressure showed a decreasing trend with normal pulmonary arterial pressure (117 mmHg-59 mmHg-33 mmHg) (Figs. 6) 3 weeks after surgery. Serum α-fetoprotein levels dropped to normal limits during the neonatal period, and BNP levels showed a significant reduction. To enhance the involution of the CHH, the patient was treated with oral propranolol 3 weeks after surgery. The dose of propranolol was increased to a maximum dose of 0.5 mg/kg/day, once every 3 to 4 days to a maximum dose of 2 mg/kg/day. Post-discharge follow-up visits confirmed a continued response to treatment at the time of writing.

Discussion And Conclusion

PH is a normal and necessary state for the fetus. However, a dramatic cardiopulmonary transition occurring during the first few hours after birth transforms high-resistance pulmonary vasculature into a low-resistance vascular bed, and a 10-fold increase in pulmonary blood flow[3], failure which results in the development of PH in neonates. PH is secondary to damaged or delayed relaxation of the pulmonary vasculature, which is associated with various groups of cardiopulmonary pathologies. As reported by the current WSPH Paediatric Task Force, associated disorders can be generally be characterized as one of three types: intrathoracic disease (infection, asphyxia); structural cardiac diseases, or hepatic and cerebral arteriovenous malformations[4]. Consequently, the antidiastole should include liver and cranial systemic arteriovenous fistulas for any newborn presenting with unexplained PH without cardiopulmonary disease. Moreover, appropriate imaging studies should be performed.

The newborn in the case study presented wirh symptoms and signs in compliance with PH, although she had no severe lung diseases or a structural cardiovascular system. She had a noncardiac cause of PH secondary to the extracardiac shunting from arteriovenous malformations in the liver. Hepatic tumors among pediatric patients are a rare, accounting for only 2% − 3% of all pediatric solid tumors[5]. Infantile hepatic hemangioma(IHH) is the most common hepatic tumor occurring in infancy. CHH is a rare condition. The precise incidence is unknown, but it likely occurs in less than 1% of all infants[6]. The mean age of onset of PH due to congenital arteriovenous malformations in the liver was reported to be 4–5 years of age; nevertheless, both could be discovered during the neonatal and early infantile periods[7]. Furthermore, the shunt vessel size in CHH did not correlate with the emergence of PH [8, 9]. . The mortality rate of PH caused by CHH is approximately 40–50% in utero and generally reaches its peak size before or at birth. Newborns may present with thrombocytopenia, hypofibrinogenemia, intratumoral bleeding, and anemia after birth[10]. Meanwhile, CHH can act as an arteriovenous fistula causing life-threatening high-output cardiac failure and respiratory distress. Smilarity, our patient had symptoms characteristic of PH, tachypnea, and cardiomegaly after birth. Liver ultrasonography is the most often performed initial diagnostic test for the radiologic diagnosis of CHH, but MRI and CT are the modalities of choice for radiologic confirmation of CHH. The patient’s diagnosis was confirmed using a combination of a ultrasonography and CT scan(Figs. 1 and 2, respectively).

There are diverse medical treatments for liver hemangiomas, including follow-up observation, medical, endovascular, surgical, and a combination of these therapies. The therapy chosen mostly relies on the clinical condition and the experience of the treatment center. In patients with or no mild symptoms, close follow-up observation may be appropriate. CHH is a high-flow vascular tumor that can cause PH and cardiac failure. Therefore, symptomatic CHH requires aggressive treatment. Surgery has been advocated when follow-up observations and medical therapies are insufficient. Invasive interventions, including surgical resection and embolization, are all available method modalities that can enhance overall prognosis.

In our patient, progressive PH required intervention. Our treatment was initially focused on liquid capacity, with diuresis and fluid restriction as needed. However, with the increasing severity of PH, severe AP, and AV shunts, emergency transcatheter intervention (arterial embolization) was thought to be the appropriate and least-invasive treatment of choice compared with surgery. Successful reduction of the cardiac preload following embolization improved the PH in our patient improved following embolization.

We have reported a case of CHH in a term newborn presenting with PH. Due to the significantly increasing PH and dilatation of the heart, an arterial embolization of the liver hemangioma was therapeutic, and she improved quickly after the embolization. More importantly, this case illustrates the importance of suspicion and prompt evaluation of CHH and related systemic arteriovenous shunts among infants with unexplained PH. Perinatal management of this kind of condition is a challenging task and should be carried out in tertiary centers with equipment including NICU and endovascular interventional techniques and pediatric surgery.

Abbreviations

PH: Pulmonary hypertension

CHH: Congenital hepatic hemangioma

CHD: Congenital heart disease

IHH: Infantile hepatic hemangioma

Declarations

Ethical approval and consent

The experimental protocol was established, according to the ethical guidelines of the Helsinki Declaration and was approved by the Human Ethics Committee of The Ningbo Women and Children’s Hospital. Written informed consent was obtained from individual or guardian participants. Informed Consent From parents was obtained(patient was a baby).

Consent to publish

Consent from parents was obtained.

Funding information

This work was supported by Ningbo Leading Medical & Health Discipline(2019A21002) ; Medical Health Science and Technology Project of Zhejiang Provincial Health Commission (2021KY323); Ningbo public welfare science and technology project (2021S154).

Conflict of interest

The authors have indicated they have no potential conflicts of interest to disclose.

Author contribution

Qianqin Zhou wrote the main manuscript text and Juan Jiang, Yinquan Xu, Hanyan Qiu, Xiaoyan Wen, Shaoqi He prepared figures 1-6. All authors reviewed the manuscript.

Availability of data and materials

All data generated or analysed during this study are included in this published article.

Acknowledgement

This work was supported by Ningbo Leading Medical & Health Discipline(2019A21002) ; Medical Health Science and Technology Project of Zhejiang Provincial Health Commission (2021KY323); Ningbo public welfare science and technology project (2021S154).

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