The object of this research is to investigate the effect of cutting parameters such as cutting speed (Vc), feed rate (f) and depth of cut (ap) on machining parameters including cutting temperature (TC) and tool flank wear (VB) during dry turning of AISI 316L using coated carbide tool. The experiments were conducted according to Taguchi L27 orthogonal array, RSM and ANN have been used. Results revealed that (ap) found to be the dominant factor for TC. VB mainly influenced by Vc, f and ap, respectively. The prediction results obtained by ANN and RSM models showed a good agreement with experimental data. However, ANN models proved their capability to provide more accurate results compared to RSM models. According to the optimization analysis, Desirability function showed good accuracy in optimization.