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Research Article
Kentaro Takezawa
Osaka University
Corresponding Author
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This work is licensed under a CC BY 4.0 License. Read Full License
Purpose: To determine the pathophysiology of nocturnal polyuria associated with renal dysfunction.
Methods: Patients who underwent laparoscopic nephrectomy were studied prospectively. The diurnal variation in urine volume, osmolality, and salt excretion were measured on preoperative day two and postoperative day seven. The factors associated with an increase in the nighttime urine volume rate with decreased renal function were evaluated by multiple linear regression analysis.
Results: Forty-nine patients were included. The eGFR decreased from 73.3 ± 2.0 to 47.2 ± 1.6 mL/min/1.73 m2 (P < 0.01) and the nighttime urine volume rate increased from 40.6% ± 2.0% to 45.3% ± 1.5% (P = 0.04) with nephrectomy. The nighttime urine osmolality decreased from 273 ± 15 to 212 ± 10 mOsm/kg (P < 0.01) and the nighttime salt excretion rate increased from 38.7% ± 2.1% to 48.8% ± 1.7% (P < 0.01) with nephrectomy. Multiple linear regression analysis revealed that the increase in the nighttime urine volume rate was strongly affected by the increase in the nighttime salt excretion rate.
Conclusion: A decrease in renal function causes an increase in the nighttime urine volume rate, mainly due to an increase in nighttime salt excretion.
Trial registration number: UMIN000036760 (University Hospital Medical Information Network Clinical Trials Registry)
Date of registration: From June 1st, 2019 to October 31th 2020
Keywords
nocturia, nocturnal polyuria, kidney disease, renal dysfunction
Figure 1
No competing interests reported.
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Review #1 received
Received 14 Mar, 2021
Reviewer #5 agreed
On 09 Mar, 2021
Reviewer #2 agreed
On 09 Mar, 2021
Reviewer #7 agreed
On 09 Mar, 2021
Reviewer #1 agreed
On 09 Mar, 2021
Reviewer #8 agreed
On 09 Mar, 2021
Reviewer #3 agreed
On 09 Mar, 2021
Reviewer #9 agreed
On 09 Mar, 2021
Reviewer #6 agreed
On 09 Mar, 2021
Reviewer #4 agreed
On 09 Mar, 2021
Reviewers invited
Invitations sent on 08 Mar, 2021
Editor assigned
On 08 Mar, 2021
Editor invited
On 02 Mar, 2021
Submission checks complete
On 02 Mar, 2021
First submitted
On 17 Feb, 2021
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Subject Areas
Urology & Nephrology
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This preprint is under consideration at Scientific Reports. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Kentaro Takezawa
Osaka University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 03 Mar, 2021
No community comments so far
Editorial decision: Major revision
On 22 Mar, 2021
Review #2 received
Received 14 Mar, 2021
Review #3 received
Received 14 Mar, 2021
Review #4 received
Received 14 Mar, 2021
Review #1 received
Received 14 Mar, 2021
Reviewer #5 agreed
On 09 Mar, 2021
Reviewer #2 agreed
On 09 Mar, 2021
Reviewer #7 agreed
On 09 Mar, 2021
Reviewer #1 agreed
On 09 Mar, 2021
Reviewer #8 agreed
On 09 Mar, 2021
Reviewer #3 agreed
On 09 Mar, 2021
Reviewer #9 agreed
On 09 Mar, 2021
Reviewer #6 agreed
On 09 Mar, 2021
Reviewer #4 agreed
On 09 Mar, 2021
Reviewers invited
Invitations sent on 08 Mar, 2021
Editor assigned
On 08 Mar, 2021
Editor invited
On 02 Mar, 2021
Submission checks complete
On 02 Mar, 2021
First submitted
On 17 Feb, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Urology & Nephrology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose: To determine the pathophysiology of nocturnal polyuria associated with renal dysfunction.
Methods: Patients who underwent laparoscopic nephrectomy were studied prospectively. The diurnal variation in urine volume, osmolality, and salt excretion were measured on preoperative day two and postoperative day seven. The factors associated with an increase in the nighttime urine volume rate with decreased renal function were evaluated by multiple linear regression analysis.
Results: Forty-nine patients were included. The eGFR decreased from 73.3 ± 2.0 to 47.2 ± 1.6 mL/min/1.73 m2 (P < 0.01) and the nighttime urine volume rate increased from 40.6% ± 2.0% to 45.3% ± 1.5% (P = 0.04) with nephrectomy. The nighttime urine osmolality decreased from 273 ± 15 to 212 ± 10 mOsm/kg (P < 0.01) and the nighttime salt excretion rate increased from 38.7% ± 2.1% to 48.8% ± 1.7% (P < 0.01) with nephrectomy. Multiple linear regression analysis revealed that the increase in the nighttime urine volume rate was strongly affected by the increase in the nighttime salt excretion rate.
Conclusion: A decrease in renal function causes an increase in the nighttime urine volume rate, mainly due to an increase in nighttime salt excretion.
Trial registration number: UMIN000036760 (University Hospital Medical Information Network Clinical Trials Registry)
Date of registration: From June 1st, 2019 to October 31th 2020
Figure 1
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