Ethics approval and consent to participate
CKDopps was approved by national and/or local ethics committees, and patient consent was obtained as required by local ethics regulations.
The ethics committee that approved the study and the committee’s reference number was: Salus IRB #14004 (currently on approval 14004-10A).
Consent for publication
Not applicable
Availability of data and materials
The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
Competing interests
VC-S reports consulting fees and honoraria from Baxter Brazil; Participation on a Data Safety Monitoring Board or Advisory Board for Brazilian Society of Nephrology, International Society of Nephrology, Latin America Chapter- International Society of Peritoneal Dialysis.
MMYW reports contracts or grants from Michael Smith Health Research BC; consulting fees from George Clinical; Participation on a Data Safety Monitoring Board or Advisory Board for AstraZeneca CKD Early identification and Intervention in Primary Care Advisory Board.
KM and DM are employees of Arbor Research Collaborative for Health, which administers the DOPPS Pograms. DOPPS is supported by private and public sources, see https://www.dopps.org/AboutUs/Support.aspx.
DC reports grants or contracts from Medtronic, Novo Nordisk, Gilead, Amgen; consulting fees from CSL Behring, Gilead, Novo Nordisk, GSK, Eli Lilly, Boehringer, Amgen, Merck, Renalytix, Janssen; Support for attending meetings and/or travel from NovoNordisk; Participation on a Data Safety Monitoring Board or Advisory Board for Astra Zeneca, Allena.
HR has no conflicts to declare.
BR was an employee of Arbor Research Collaborative for Health, which administers the DOPPS Program. Global support for the ongoing DOPPS Program is provided without restriction on publications by a variety of funders. For details see https://www.dopps.org/AboutUs/Support.aspx.
Benedicte Stengel. He reports consulting fees or travel reimbursement since 2019 from AstraZeneca, GlaxoSmithKline, Kyowa Kirin Co., and Monogram Health, all paid directly to his institution of employment.
BS reports grants or contracts from Amgen 2012-2020, GSK since 2012, AstraZeneca since 2018, Lilly France from 2013 to 2018, MSD 2012-2017, Vifor Fresenius France since 2018, Otsuka Pharmaceutical from 2015 to 2020, Fresenius Medical Care since 2012
ZAM declares support from Amgen, Baxter, Fresenius Medical Care, GlaxoSmithKline, Merck Sharp and Dohme-Chibret, Genzyme/ Sanofi, Lilly, Otsuka, Astra Zeneca and Government support for CKD REIN PROJECT AND EXPERIMENTAL PROJECTS; and consulting fees and honoraria from GSK, Boehringer.
RP-F declares support from Amgen; consulting fees and honoraria from Bayer, Boehringer, Astra Zeneca, GSK, Akebia, Fibrogen, Fresenuis Medical Care; Participation on a Data Safety Monitoring Board or Advisory Board for Bayer, Boehringer, Astra Zeneca, GSK, Akebia, Fresenuis Medical Care.
Funding
Global support for the ongoing DOPPS Programs is provided without restriction on publications by various funders. For details see https://www.dopps.org/AboutUs/Support.aspx.
Authors' contributions
VC-S: Roles/Writing - original draft; Writing - review & editing.
DM: Formal analysis; Methodology; Writing - review & editing
MMYW: Writing - original draft; Writing - review & editing
KM: Conceptualization; Formal analysis; Funding acquisition; Investigation; Methodology; Validation; Visualization; Roles/Writing - original draft; Writing - review & editing.
DC: Methodology; Writing - original draft; Writing - review & editing
HR: Writing - review & editing.
BR: Funding acquisition; Writing - review & editing.
BS: Writing - review & editing.
ZAM: Conceptualization, Methodology, Validation, Writing - review & editing
RP-F: Conceptualization; Funding acquisition; Investigation; Supervision; Writing - original draft; Writing - review & editing
All authors read and approved the final manuscript.
Acknowledgements
CKDopps Steering Committee and Country Investigators: Antonio Lopes, Roberto Pecoits-Filho (Brazil); Christian Combe, Christian Jacquelinet, Ziad Massy, Benedicte Stengel (France); Johannes Duttlinger, Danilo Fliser, Gerhard Lonnemann, Helmut Reichel (Germany); Takashi Wada, Kunihiro Yamagata (Japan); Ron Pisoni, Bruce Robinson (United States).
Additional CKDopps Research Group: Viviane Calice da Silva, Ricardo Sesso (Brazil); Elodie Speyer, Natalia Alencar de Pinho (France); Koichi Asahi, Junichi Hoshino, Ichiei Narita (Japan); Rachel Perlman, Friedrich Port, Nidhi Sukul, Michelle Wong, Eric Young, Jarcy Zee (United States).
Jennifer McCready-Maynes, an employee of Arbor Research Collaborative for Health, provided editorial support.