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Research Article
Gong Rongpeng
Qinghai University Medical College
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Previous studies have shown that hyperuricemia is involved in diabetes, obesity, hypertension, chronic kidney disease, and other diseases. At the same time, studies have shown that vitamin D3 levels in the body are linked to the onset of diabete. However, there is currently no sufficient evidence to prove whether this connection is affected by uric acid levels. Therefore, we attempted to investigate the relationship between vitamin D3 content and the occurrence of diabetes in the hyperuricemia population by using the data of the NHANES database from 2009 to 2018.
Method
We conducted a cross-sectional study using the NHANES database. According to strict inclusion and exclusion criteria, we finally selected 3543 representative data. Multivariate logistic regression analysis was used to explore the relationship between vitamin D3 and diabetes in the hyperuricemia population after complete adjustment. We found a linear relationship between vitamin D3 content and the incidence of diabetes.
Result
The results of this study showed that there was a correlation between the content of vitamin D3 and the incidence of diabetes in people with hyperuricemia, and the effect values (OR and 95% confidence interval) were 0.95and (0.92-0.98), respectively, and the difference was statistically significant.
Conclusion
Our study shows that vitamin D3 content is associated with the incidence of diabetes in people with high uric acid. This study provides a new idea for exploring the factors affecting the pathogenesis of diabetes in patients with hyperuricemia.
Keywords
hyperuricemia, vitamin D3, diabetes mellitus, a cross-sectional study
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CURRENT STATUS: Under Review
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Posted 19 Apr, 2021
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Received 16 Apr, 2021
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Subject Areas
Endocrinology & Metabolism
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
This preprint is under consideration at Endocrine. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Gong Rongpeng
Qinghai University Medical College
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 19 Apr, 2021
No community comments so far
Reviewers invited
Invitations sent on 16 Apr, 2021
Reviews received
Received 16 Apr, 2021
Editor assigned
On 23 Feb, 2021
First submitted
On 17 Feb, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Endocrinology & Metabolism
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Previous studies have shown that hyperuricemia is involved in diabetes, obesity, hypertension, chronic kidney disease, and other diseases. At the same time, studies have shown that vitamin D3 levels in the body are linked to the onset of diabete. However, there is currently no sufficient evidence to prove whether this connection is affected by uric acid levels. Therefore, we attempted to investigate the relationship between vitamin D3 content and the occurrence of diabetes in the hyperuricemia population by using the data of the NHANES database from 2009 to 2018.
Method
We conducted a cross-sectional study using the NHANES database. According to strict inclusion and exclusion criteria, we finally selected 3543 representative data. Multivariate logistic regression analysis was used to explore the relationship between vitamin D3 and diabetes in the hyperuricemia population after complete adjustment. We found a linear relationship between vitamin D3 content and the incidence of diabetes.
Result
The results of this study showed that there was a correlation between the content of vitamin D3 and the incidence of diabetes in people with hyperuricemia, and the effect values (OR and 95% confidence interval) were 0.95and (0.92-0.98), respectively, and the difference was statistically significant.
Conclusion
Our study shows that vitamin D3 content is associated with the incidence of diabetes in people with high uric acid. This study provides a new idea for exploring the factors affecting the pathogenesis of diabetes in patients with hyperuricemia.
Figure 1
Figure 2
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