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Research Article
Bong Soo Kyung
Barunsesang Hospital
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose
We compared the clinical and radiologic results of human umbilical cord-blood derived mesenchymal stem cells (hUCB-MSCs)cartilage regeneration procedures combined with HTO to those of microfracture with HTO.
Methods
From August 2017 to December 2018, HTO patients with International Cartilage Regeneration and Joint Preservation Society (ICRS) grade IV cartilage defects over 200 mm2 on medial femoral condyle (MFC) were enrolled. For comparison, all participants were divided into two groups: those who had undergone an hUCB-MSC induced cartilage regeneration procedure (group MSC) and those with microfractures only (group C, controls). Clinically, Hospital for Special Surgery (HSS), International Knee Documentation Committee (IKDC), and Lysholm scores were evaluated post-operatively at 18 months. Radiologically, mechanical axis (MA) and joint space width (JSW) were evaluated.
Results
A total of 100 knees were enrolled (43 in group MSC, 57 in group C). The IKDC score in group MSC (69) was better than that in group C (62; P < 0.05). The JSW increment in the MSC group (0.6 mm) was more than that in group C (0.1 mm; P < 0.05). No patient developed nonunion, correction loss, or arthroplasty conversion.
Conclusion
hUCB-MSCs can improve clinical outcome and JSW better than microfracture only in HTO patients.
Keywords
knee, medial osteoarthritis, cartilage defect, umbilical cord-blood-derived mesenchymal stem cell, high tibial osteotomy
Figure 1
Figure 2
No competing interests reported.
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Received 05 Apr, 2021
Reviewer #1 agreed
On 22 Mar, 2021
Reviewer #17 agreed
On 22 Mar, 2021
Reviewer #3 agreed
On 22 Mar, 2021
Reviewer #19 agreed
On 22 Mar, 2021
Reviewer #18 agreed
On 22 Mar, 2021
Reviewer #9 agreed
On 22 Mar, 2021
Reviewer #10 agreed
On 22 Mar, 2021
Reviewer #8 agreed
On 22 Mar, 2021
Reviewers invited
Invitations sent on 19 Mar, 2021
Editor assigned
On 19 Mar, 2021
Editor invited
On 03 Mar, 2021
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On 03 Mar, 2021
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Subject Areas
Stem Cell & Developmental Cell Biology
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This preprint is under consideration at Scientific Reports. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Bong Soo Kyung
Barunsesang Hospital
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 10 Mar, 2021
No community comments so far
Review #8 received
Received 05 Apr, 2021
Review #10 received
Received 05 Apr, 2021
Review #9 received
Received 05 Apr, 2021
Review #1 received
Received 05 Apr, 2021
Reviewer #1 agreed
On 22 Mar, 2021
Reviewer #17 agreed
On 22 Mar, 2021
Reviewer #3 agreed
On 22 Mar, 2021
Reviewer #19 agreed
On 22 Mar, 2021
Reviewer #18 agreed
On 22 Mar, 2021
Reviewer #9 agreed
On 22 Mar, 2021
Reviewer #10 agreed
On 22 Mar, 2021
Reviewer #8 agreed
On 22 Mar, 2021
Reviewers invited
Invitations sent on 19 Mar, 2021
Editor assigned
On 19 Mar, 2021
Editor invited
On 03 Mar, 2021
Submission checks complete
On 03 Mar, 2021
First submitted
On 19 Feb, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Stem Cell & Developmental Cell Biology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose
We compared the clinical and radiologic results of human umbilical cord-blood derived mesenchymal stem cells (hUCB-MSCs)cartilage regeneration procedures combined with HTO to those of microfracture with HTO.
Methods
From August 2017 to December 2018, HTO patients with International Cartilage Regeneration and Joint Preservation Society (ICRS) grade IV cartilage defects over 200 mm2 on medial femoral condyle (MFC) were enrolled. For comparison, all participants were divided into two groups: those who had undergone an hUCB-MSC induced cartilage regeneration procedure (group MSC) and those with microfractures only (group C, controls). Clinically, Hospital for Special Surgery (HSS), International Knee Documentation Committee (IKDC), and Lysholm scores were evaluated post-operatively at 18 months. Radiologically, mechanical axis (MA) and joint space width (JSW) were evaluated.
Results
A total of 100 knees were enrolled (43 in group MSC, 57 in group C). The IKDC score in group MSC (69) was better than that in group C (62; P < 0.05). The JSW increment in the MSC group (0.6 mm) was more than that in group C (0.1 mm; P < 0.05). No patient developed nonunion, correction loss, or arthroplasty conversion.
Conclusion
hUCB-MSCs can improve clinical outcome and JSW better than microfracture only in HTO patients.
Figure 1
Figure 2
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