Using natural language from a smartphone pregnancy app to identify maternal depression

Depression is highly prevalent in pregnancy, yet it often goes undiagnosed and untreated. Language can be an indicator of psychological well-being. This longitudinal, observational cohort study of 1,274 pregnancies examined written language shared in a prenatal smartphone app. Natural language feature of text entered in the app (e.g. in a journaling feature) throughout the course of participants’ pregnancies were used to model subsequent depression symptoms. Language features were predictive of incident depression symptoms in a 30-day window (AUROC = 0.72) and offer insights into topics most salient in the writing of individuals experiencing those symptoms. When natural language inputs were combined with self-reported current mood, a stronger predictive model was produced (AUROC = 0.84). Pregnancy apps are a promising way to illuminate experiences contributing to depression symptoms. Even sparse language and simple patient-reports collected directly from these tools may support earlier, more nuanced depression symptom identification.


Introduction
Perinatal depression has signi cant impacts on both maternal and infant wellbeing. Maternal depression is associated with adverse birth outcomes, including low birth weight and preterm birth 1-2 as well as delayed infant development [3][4][5][6][7][8] . Maternal suicide accounts for as much as 20% of postpartum mortality [9][10] . During pregnancy, approximately 15% of women report experiencing depression, making it one of the most common co-occurring health conditions in pregnancy 11 . True rates of maternal depression may be even higher due to disclosure barriers of social stigma and limited physician time to address mental health during prenatal care 12 . While screening instruments for perinatal depression have been recommended (e.g., Edinburgh Postnatal Depression Scale 13 and PHQ-9/PHQ-2 14 ), they are not consistently administered at routine prenatal care, worsening the problem of adequate detection.
Moreover, while these metrics identify likelihood of a diagnosis of major depression, they offer limited insight into the underlying issues triggering or exacerbating depressed mood.
Digital health applications are now prevalent in almost every aspect of healthcare delivery in the United States 15 . Pregnancy is no exception, with more mobile health apps available for use during pregnancy than for any other clinical domain 16 . While many of these tools are directly marketed to consumers, others are designed by or delivered directly from healthcare systems and may serve as a useful form of ongoing connection to a healthcare provider in between routine prenatal visits 17 . Many individuals report the desire to use a smartphone to disclose and receive feedback about personal or sensitive health information 18 . Therefore, smartphone apps may also offer a way for pregnant people to disclose stigmatized information more easily 19 .
Natural language serves as an indicator of mental health status. The words we select and the sentiment of our statements offer a window into our wellbeing 20 . Moreover, the themes in our narratives may identify the foci of our rumination. Recent promising natural language processing (NLP) models have included information extracted from large-scale datasets in conjunction with more domain-specialized language guided by practitioner expertise [21][22][23][24][25] . Zhang and colleagues reviewed studies speci cally detecting mental illness using NLP methods and found that the vast majority applied these methods to text that had been extracted from large social media forums or electronic health records 26 . These NLP models of prediction generally seek out extensive datasets because the black box approaches they employ require them to train large numbers of parameters. A much smaller number of the studies they reviewed -2% -used an individual's own narrative writing to identify depression. However, even limited amounts of narrative text may be useful in identifying an individual at risk of poor mental health 27 . Thus, narrative language provided by patients through pregnancy apps may offer an additional opportunity for healthcare providers to identify maternal depression risk while gaining a better understanding of the underlying nature of an individual patient's stressors.
Here, we collected rst-person narrative text entries as well as depression symptom scores using a prenatal care app prescribed by obstetrical care providers to their patients for use during pregnancy. We then used these data to predict depression symptom scores from features of natural language, employing four distinct NLP approaches. Figure 1 details the process by which we generated 4 sets of unique language feature scores that can be entered as inputs into a single regularized linear regression predicting depression symptom scores. Sentiment analysis tools (here we used SentiWordNet) estimate positive or negative valence in words and clarify the writer's attitude about their subject 28 . The Linguistic Inquiry and Word Count dictionary (LIWC), where expert insight seeded psychologically-informed themes, has shown utility in identifying pre-speci ed topics associated with mental health issues 21,24,29,30 . Topic modeling can elucidate emergent themes particular to speci c domains of writing 31 that may not be present in more generalized NLP datasets developed on news articles and historical texts. Word2vec features provide a representation of words' syntactic and semantic features based on the context of their use in vast bodies of pre-training text 32 .
The goal of this study was to determine if (a) the type of digital support routinely offered to patients as part of prenatal care could be used to identify pregnancy depression symptoms from patient-entered natural language and (b) if those natural language features could provide insight into the most salient themes associated with depression symptoms during pregnancy. This study was pre-registered on the Open Science Framework at https://osf.io/tydfh.

Study participants
During the study period of September 2019 -October 2022, the MyHealthyPregnancy app was used by 7,455 individuals who had been prescribed the app as part of their routine prenatal care and agreed to share their deidenti ed data for scienti c research. While engaging with the larger set of pregnancy monitoring and education features included in the app, individuals experiencing a total of 1,274 pregnancies (a small number used the tool for more than one pregnancy) provided at least one openended text entry and voluntarily completed at least one 10-item Edinburgh Postnatal Depression Scale (EPDS) to self-report depression symptoms in the app. This subset of app users was then enrolled in the study and randomly divided into a test set, development set, and training set with a respective split of 15%, 15% and 70% of participants (Fig. 2). Of these, 59.42% (N = 757) provided enough language in openended text entries for meaningful feature extraction within the 60-day period preceding an EPDS score.
The nal split was 122 participants (16.1%) in the test set, 118 participants (15.5%) in the development set, and 517 participants (68.3%) in the training set. Table 1 displays the baseline demographic categories and relevant clinical history, which were provided by participants upon initiating app use and have been shown in prior literature to predict depression in pregnancy 33 . Most participants identi ed as non-Hispanic White/Caucasians and were partnered. The mean age of participants was 29.8 years (SD = 5.4 years). Most had a college education or higher. The majority reported a family household income of at least $50,000 annually. The demographic characteristics of those included in the study were largely re ective of the greater population of MyHealthyPregnancy app users, with few signi cant differences between app users enrolled in the study and app users who were not enrolled. However, participants who were enrolled were more likely to have a household income of less than $50,000/year and were more likely to report histories of depression and/or anxiety (Supplementary Table 1).  I'm obsessing, getting the baby's room ready. There's a ton of stuff out there but not sure what's immediately necessary. Also had a migraine this morning (took some meds) and issues with food aversions this week. Having some mood swings too, it comes and goes throughout the day but it's alright for now.
Shorter entries were typically explanations in response to open-ended prompts (e.g., "What had the biggest impact on your mood today, and why?" with a sample response of "Good mood today b/c of ultrasound") rather than unprompted entries.

Self-reported mood on a Likert scale
Participants could also self-report mood through the app as frequently as once a day on a 5-point Likert scale. Participants responded to a prompt of "How is your mood today?"; reporting daily mood scores ranging from 1 ("Very Poor") to 5 ("Very good"). Among the text entries eligible for modeling, 92% of entries were paired with at least one co-occurring report of mood. with a mean mood across participant responses of 3.88. Among those who shared their current mood in the app, mood was reported an average 5.4 times in the month prior to completing an EPDS.

Depression model using language inputs derived from text entries
In a Least Absolute Shrinkage and Selection Operator (LASSO) model (see Table 2), which included baseline demographic categories and relevant clinical history, natural language features were found to be predictive of moderate to severe prenatal depression symptoms occurring in a subsequent 30-day timeframe in the test set (AUROC = 0.72) and to a slightly lesser extent in the subsequent 60-day timeframe (AUROC = 0.69). The addition of self-reported current mood around the time of text entry noticeably increased the predictive performance of the model (AUROC = 0.84 and AUROC = 0.81 for 30day and 60-day timeframes, respectively). The number of NLP features retained in each model and their coe cients are shown in Table 3. The 30day and 60-day timeframe models retained 17 and 19 natural language features, respectively. Across both timepoints, sentiment uctuation (SentiWordNet differences in positive and negative sentiment scores), LIWC (psychologically-informed) themes, and word2vec (underlying semantic and syntactic) features all predicted depression symptoms. When self-reported mood was included, sentiment uctuation was no longer retained in the model for either timeframe, and several LIWC themes were dropped. Additionally, when mood was included, a greater number of word2vec features were retained, with the maximum coe cient among word2vec features increasing from 0.17 to 0.26 in the 60-day timeframe. Emergent topics (from topic modeling) were not retained in any of the models.  Table 4 shows coe cients of the most predictive SentiWordNet score (sentiment uctuation), the LIWC summary characteristics and psychological process themes, and the most predictive word2vec features that were associated with subsequent moderate to severe depression symptoms. In both the 30-day and 60-day models, sentiment uctuation (i.e., the difference between the degree of positive and negative sentiment present in text entries) was negatively associated with subsequent depression symptoms, although the strength of the relationship between sentiment uctuation and depression symptoms was much stronger in the 30-day time period. In both time periods, one of the most protective language features against depression symptoms was the use of rst-person plural pronouns, such as we and ours. Language related to want (e.g., wish, crave, hope), language related to mental health (e.g., antisocial, trauma, suicide), and language related to space (e.g., home, around) were all positively associated with subsequent depression symptoms. Language related to time (e.g., today, nally) was negatively associated with subsequent depression symptoms. When participants' current mood was added to the 30-day model, only the LIWC theme of mental health was retained, though with a reduced coe cient, and language related to pregnancy & reproductive health emerged as positively associated with subsequent depression symptoms. The tone of writing was strongly associated with decreased depression symptoms in the language models in both timeframes but was no longer retained once current mood was accounted for. Word count had a small but positive association with depression symptoms in all models.
A modi ed text sample indicative of moderate to severe depression is as follows: I haven't been sleeping well, so it's hard to get out of bed. Then it's hard for me to cope with the stress at work. I'm so tired and I just want to be at home. My husband and I talked about how to support me more because I'm really struggling doing all this on my own. I want this fatigue to stop ASAP. Today I had an ultrasound -the heart rate was 130. I think that means ITS A BOY and I'm kind of freaking out A modi ed text discussing the same topics but without depression-indicative language features is as follows: I've been working a lot lately and sleep isn't as easy as it used to be. I'm tired a lot, but my husband's been taking care of chores in the evening to lighten the load. And today we had an ultrasound and got to see our little girl moving around!! I can't wait to watch her grow, and I'm so happy we're all in this together.
Lastly, several word2vec features were positively associated with depression symptoms. Word2vec feature 166, for example, was positively associated with depression symptoms at both 30-day and 60day timepoints, whether or not mood was included in the model. Upon qualitative review of these word2vec features, it was not immediately obvious what underlying language dimension differentiates those with high scores from those with low scores. Those with the highest scores on feature 166, for example, tended to write lengthier, more detailed responses than those with the lowest scores, and often referenced interpersonal con ict (e.g., ghts with partners, tension with co-workers). Given this qualitative observation, it is possible that response length is an aspect of the underlying structure driving the positive link between word2vec features and depression but does not fully explain the relationship between word2vec features and degree of depression symptoms.

Discussion
In this observational prospective cohort study, we modeled depression symptoms using NLP outputs from sparse written text collected through a pregnancy smartphone app that was delivered to patients are part of their routine prenatal care. The model had performance matching or better than other machine learning models for maternal depression prediction, which often have been built on larger data sets with a greater number of variables [34][35] . Our results add to a new, but growing, literature indicating that even sparse language can be used to predict depression symptoms. Moreover, this study focuses on a population for whom depression can have severe consequences. By capturing language through a prenatal smartphone app, this study also lays a foundation for wider-scale remote assessment of maternal depression from patients' everyday language.
Speci cally, we nd that natural language features, including tone, rst-person plural pronoun use, speci c topics, such as space, mental and pregnancy-related health, and temporal wants, context-derived syntactic and semantic dimensions, and word count are indicative of depression symptoms. Moreover, these features capture a unique aspect of symptom level beyond current mood or baseline demographics or clinical risk factors. The best-performing model identi ed incident depression in a 30-day window with mood, topics focused on mental health and pregnancy-related health issues, and syntactic/semantic features all associated with depression symptoms. Pronoun use and topics associated with depression symptoms could re ect aspects of social isolation, e.g., use of "I" rather than "we" and references to staying in or needing to be in certain physical spaces. Our results also shed light on the types of topics that current mood may be capturing, such as temporal desires (captured by the LIWC topic, wants, -e.g., "wish", "hopeful").
In an illustrative contrast to prior studies nding that use of the rst-person singular is associated with depression 36-40 , we nd that rst-person plural pronoun use is negatively associated with (or protective against) depression symptoms. The use of rst-person plural pronouns in our predominantly partnered sample, particularly during pregnancy, could be indicative of the strength of the existing family structure. Use of "we" rather than "I" when discussing pregnancy may indicate degree of bonding in the partnership unit or the mother-infant dyad, consistent with literature on the protective effects of social support and mother-child bonding 41 . This linguistic focus on rst-person plural pronouns may indicate a protective counterpoint of social supports in opposition to the self-focus or self-criticism suggested by rst-person singular pronouns that has been shown to be harmful in prior work 35,[42][43] .
Notably, the theme of mental health was retained as a predictive language feature in the 30-day timeframe when controlling for mood and other baseline characteristics. That those with moderate to severe depression symptoms were writing about their mental health (e.g., psychiatrist, zoloft, trauma) is suggestive of the writer's existing understanding of their depression status and perhaps a sensitivity to their own ebbs and ows. Previous studies have shown that those who are depressed may nd writing therapeutic 44 , while others have found that re-living events can be either therapeutic or harmful 45 . Here, when given the opportunity to share writing in a pregnancy app, individuals experiencing depression symptoms wrote about their mental health and wrote more extensively than those who were not depressed. In addition to being a tool for eliciting depression symptoms in between routine prenatal care, such tools may offer an additional opportunity for sharing, particularly if structured in a way to support therapeutic rather than harmful disclosure of experiences. To do this effectively, future work should explore the structure of digital tool-based elicitation of writing to understand which prompts and formats of writing-elicitation allow for therapeutic disclosure.
Much of our data was collected during a pandemic and through periods of mandated self-isolation with fewer in-person clinical appointments. However, even though COVID-19 was explicitly included as a novel LIWC theme in modeling, it was not retained as an indicator for depression symptoms in our modeling. This result suggests that other topics, which may be consequent to COVID-19 pandemic experiences but do not speci cally reference COVID-19 precautions or symptoms, are more directly indicative of depression.
Consistent with other literature 46-48 , we nd that a lack of uctuation in a text's sentiment is symptomatic of depression (i.e. less varied -or " attened" -affect in language is associated with depression symptoms). We also nd that high-dimensional representations of the underlying syntactic and semantic content of open-ended text, captured by word2vec features, were indicative of depression symptoms, even more so when paired with self-reported mood. While the word2vec features are not easily interpretable, these ndings suggest that there is something about underlying word choice that is uniquely informative and distinct from explicitly psychologically meaningful themes. Future work should examine whether these word-based language features could be used as an automated trigger for depression screening among patients of a speci c healthcare system, as has been discussed in the context of social media 49 .
Our ndings should be interpreted in the context of its naturalistic, patient-led data generation. While the self-motivated collection approach translates clearly to practice, the resulting data are sparse and tend to be highly topically focused. Thus, we may not have fully captured the range of language features that could indicate depression symptoms among pregnant people in a more directed data collection structure. For example, we did not nd any emergent topics associated with depression symptoms in this sample, likely due to topic models' need for larger bodies of text. It is possible that the number and, especially, length of the written texts may not have been su cient to expose more subtle or infrequent but meaningful themes. Future work could include manual coding of the entries to clarify more nuanced themes and experimental data collection with and without clear writing prompts.
The naturalistic structure of the study added some noise to our text. Some individuals used open-ended text opportunities to track blood pressure readings or take notes on medical appointments. How individuals used the open-ended writing opportunities in the tool is something that could be explored in future work. We nd that individuals with a history of depression or anxiety tend to use the overall tool for longer and write more frequently. However, this disproportionate use of the tool by those who have a history of depression may also be a strength if prenatal apps offer an additional means of therapeutic disclosure and connection to patients who are more likely to become depressed.
To the best of our knowledge, this is one of the rst prospective longitudinal studies to use natural language collection 50 and the rst focused on maternal depression symptom prediction. Incorporating language inputs enables moderate predictive ability of depressive symptoms among peripartum patients in a large academic health system. This work points to an immediate value in using digital tools for depression symptom evaluation and support between routine clinical care appointments. It also indicates the potential for future analysis of app-elicited language to trigger mental health care provision.

Participant enrollment
The MyHealthyPregnancy smartphone application was prescribed to patients receiving prenatal care in the UPMC healthcare system as part of a quality improvement initiative (Quality Improvement/Ethics board approval project number: 1684). Prescriptions were typically made between the 7th and 10th weeks of pregnancy, at a patient's rst prenatal visit. Upon downloading the app and creating an account, participants electronically consented to the dissemination of de-identi ed aggregate data for scienti c development. The speci c analyses presented here, collected from a longitudinal observational cohort of patients, were approved by the University of Pittsburgh's Institutional Review Board (STUDY19100210)) There was no nancial compensation provided to participants for app use.

Data collection
Upon initiation of app use, participants completed baseline questions, including sociodemographic information regarding their race/ethnic identity, household income, education level, and relationship status. They were additionally asked about their history of diagnosed depressive and anxiety disorders.
Participants could record information about their pregnancy experience on a routine (up to daily) basis using a "check-in" questionnaire that included a question about their mood that day, with response options recorded on a 5-point Likert scale.
Throughout their pregnancy, participants were able to share open-ended text in the app in several ways.
First, the app contained a dedicated section for participants to voluntarily document their thoughts, feelings, symptoms, or other notes. Second, participants had opportunities to share open-ended responses to routine (weekly or monthly) questions about their current experience, covering mental and relationship wellbeing (e.g., What had the biggest impact on your mood today, and why?). Lastly, from April 2020 to September 2022, an app-embedded COVID symptom screener also included open-ended text questions asking users about their sources for COVID-19 information, preferred methods to prevent infection, and challenges during the pandemic (i.e., Are you experiencing nancial or other personal di culties as a result of this pandemic?).
The app also allowed participants to complete the Edinburgh Postnatal Depression Scale (EPDS) to monitor their mental health throughout their pregnancy. Participants were prompted on the app's home screen once a trimester to complete the questionnaire throughout the course of the study. Starting in June 2021, an update in the app made the EPDS available to participants to complete at any time.

Inclusion criteria
All users were eligible to participate if they had provided consent for deidenti ed aggregate analysis of their data for research purposes, completed an EPDS at some point during their use of the app, and entered one or more usable open-ended text entries within the 60-day window prior to providing an EPDS score. Usable text entries were de ned as English-language entries that retained at least one meaningful word after concatenated text entries had been processed to remove less meaningful words. Word removal applied to text before extraction of word2vec features, LDA topics, and sentiment. This included stopwords (such as "I", "be", and "did") and overly common words found in responses to open-ended text prompts (such as "today" and "yes"). Pre-processing also removed capitalization, punctuation marks, and accent marks.

Pairing open-ended text with depression symptom scores
To ensure that open-ended text entries could be used to model mental status, text and EPDS pairings were identi ed for which text entries preceded self-reported EPDS scores within a xed time. Two xed time frames were selected. A 60-day window was chosen to re ect the DSM-5 criteria for major depressive disorder, which de nes remission as 2 or more months of little to no depressive symptoms. A shorter 30-day window was chosen to re ect the timeframe often used by clinicians to identify depressive symptoms for a new depression diagnosis.
Participant data was rst processed by grouping together open-ended text entries with following EPDS scores. Open-ended text entries within 60 days preceding an EPDS score were concatenated together.
This concatenated text was then paired with the average of all following EPDS scores within 60 days from the last open-ended text entry in the cluster before the occurrence of a newer text entry. The same process was completed to create text and EPDS score pairings in a 30-day timeframe. With both timeframes, EPDS scores with no preceding text entries and text entries with no following EPDS scores were eliminated from the dataset. In models that included reports of mood, mood data was only included if within the same timeframe as open-ended text entries. Figure 3 shows an example of data grouped together in the 60-day and 30-day timeframe. Multiple reports of mood in the 30-day or 60-day window were averaged before use in the regression model.

Sentiment uctuation
Text sentiment was analyzed using SentiWordNet 28 . Each word extracted from a processed text entry was stemmed and given a positive or negative score using a stemmed SentiWordNet dictionary. Words that had multiple entries within the dictionary were given the average of those scores. Positive and negative scores across an entire processed text entry were averaged to give an average positive sentiment and an average negative sentiment. Finally, overall uctuation in sentiment was calculated by subtracting the average negative from average positive scores.

Themes and topics
Topic modeling was performed using Latent Dirichlet Allocation (LDA), an unsupervised machine learning method that clusters data points into a predetermined number of topics 31 . The number of LDA topics, k, was selected by iterating across ve splits of the training set and evaluating the resulting topics for predictive capacity on EPDS using LASSO. The k between 1 and 50 leading to best performance was used to run a new, nal set of topics on the full dataset. The optimal k value was found to be 5 topics. Topic models, an unsupervised method, permit us to examine domain-speci c patterns that may emerge in this text by pregnant people as distinct from general usage, and from the news media text used to train word2vec, by illustrating which less-common words frequently occur together in this body of text.
The Linguistic Inquiry and Word Count dictionary (LIWC-22) was used to count the number of occurrences of 119 themes, grammatical features, and positive and negative affect within each text entry 29 . In addition to 117 LIWC-22 themes, two additional themes were manually created to capture domain-speci c content. A COVID-19 theme included terminology related to the global health crisis, such as "mask", "booster", and "pandemic". A second theme was created for pregnancy-speci c health, which captured pregnancy terminology not fully captured in pre-existing LIWC categories. This theme included common pregnancy-related symptoms, such as "heartburn" and "contractions," as well as words that are speci c to healthcare services provided in pregnancy, e.g., "doula" or "amniocentesis." In contrast to the other NLP methods, LIWC was used on un-processed text entries to ensure the capture of pronouns, conjunctions, and other function words.
Syntactic/semantic features Word embeddings incorporate high-dimensional context-derived representations of syntactic and semantic information for each concatenated text entry. The 300-dimensional word2vec embeddings were pre-trained on word co-occurrence and proximity in 1.6 million news articles, giving similar representations to words that usually showed up in the same contexts 32 . Here, a word embedding vector was retrieved for each word in the entry, and each entry was represented by a vector of the highest value for each of the 300 features. This approach acknowledges that there is systematic regularity among word embeddings that captures meaningful information about semantic and syntactic roles 51 . While individual features are not manually interpretable, we build from the assumption that they are independently meaningful to consolidate word embeddings from each journal entry into a single summary vector.
Statistical analysis EPDS scores were predicted for each data point in the data set using LASSO, a penalized linear regression model that reduces over tting. Natural language features were standardized within the dataset prior to modeling, with a mean of 0 and a standard deviation of 1 for each feature. A ve-fold cross validation was used on the training + development set to nd the optimal shrinkage penalty for the LASSO regression in a range from 0.0001 to 1. The value minimizing averaged mean squared error in predictions was then used to train the LASSO on the entire training and development dataset. Continuous EPDS score predictions were used to calculate AUROC in predicting true test set scores with a threshold of > 13.
LASSO regression was run in the 60-day and 30-day timeframe with NLP features and demographic information. This included the participant's age at the start of their pregnancy, their race/ethnicity (White, Black, Hispanic/Latinx, Asian, or other), a binary variable for having a household income of $50,000 or more, a binary variable for having an associate degree or higher, self-reported history of depression, and self-reported history of anxiety. Secondary LASSO regressions were run in the 60-day and 30-day timeframe among the same data points that included demographic information only to serve as a comparison point.
Two exploratory analyses explored the importance of mood variation and the presence of bothersome physical symptoms by combining demographic information and language features with minimum mood, maximum mood, average mood, and a binary variable for the reporting of physical symptoms in the 60day and 30-day timeframes.

Declarations
DATA AVAILABILITY Original identi able data are not publicly available to protect patient privacy and due to the terms and conditions of app data use. De-identi ed natural language feature data will be available in the National Institute of Mental Health Data Archives.

ACKNOWLEDGEMENTS
We gratefully acknowledge Dr. Alexander Davis for offering expert guidance in the initial stages of this work and Dr. Kaleab Abebe for his role as a data steward. This work was supported by grant number R21MH119450-01from the National Institute of Mental Health. The design, collection, analysis, and interpretation of the study were independent of funding sources.

COMPETING INTERESTS
Drs. Krishnamurti and Simhan are co-founders of Naima Health LLC, which provided the data for this study. However, no nancial or material compensation was provided by Naima Health LLC to fund this work. Ms. Rodriguez and Ms. Hayani are employees of Naima Health. Drs. Krishnamurti and Allen have a patent pending for identi cation of psychosocial risk from natural language features. Dr. Moses-Kolko and Rothenberger report no con icts of interest.  STROBE ow diagram. Flowchart of enrollment in study, eligibility criteria for modeling, and split into training, development, and testing groups.