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Research Article
María Carmen Fariñas
Marqués de Valdecilla University Hospital
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Introduction:
To analyze the association between human immunodeficiency virus (HIV) infection, and the presence of subclinical atherosclerosis and endothelial dysfunction.
Methods
Prospective cohort study of HIV positive patients who underwent to intimate thickness (IMT) determination and coronary artery calcium score to determine subclinical atherosclerosis. To detect endothelial dysfunction breath holding index, flow mediated dilation and concentration of endothelial progenitor cells (EPC) were measured.
Results
Patients with an IMT ≥ 0.9 mm had an average of 559.3 ± 283.34 CD4/µl and those with an IMT < 0.9 mm 715.4 ± 389.92 CD4/µl (p = 0.04). Patients with a low calcium score had a significantly higher average of CD4 cells value and lower zenith viral load than those with a higher score (707.7 ± 377.5 CD4/µl vs 477.23 ± 235.7 CD4/µl (p = 0.01)) and (7x104 ± 5x104 c/ml vs 23.4 x 104 ± 19 x 104 c /ml (p = 0.02). Early EPCs concentration in patients with a CD4 nadir < 350/ul was lower than concentration among those presenting a CD4 nadir ≥ 350 (p = 0.03).
Conclusion
In HIV positive patients low CD4 cells levels and high viral load were associated to a higher risk of developing subclinical atherosclerosis.HIV patients with less CD4 cells may have fewer early EPCs.
Keywords
HIV, atherosclerosis, endothelial dysfunction
No competing interests reported.
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Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 11 Mar, 2021
No community comments so far
Editorial decision: Major revision
On 29 Apr, 2021
Reviews received
Received 22 Apr, 2021
Reviewers agreed
On 01 Apr, 2021
Reviewers agreed
On 19 Mar, 2021
Reviewers invited
Invitations sent on 19 Mar, 2021
Editor assigned
On 17 Mar, 2021
Editor invited
On 10 Mar, 2021
Submission checks complete
On 10 Mar, 2021
First submitted
On 20 Feb, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
This preprint is under consideration at Scientific Reports. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
María Carmen Fariñas
Marqués de Valdecilla University Hospital
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 11 Mar, 2021
No community comments so far
Editorial decision: Major revision
On 29 Apr, 2021
Reviews received
Received 22 Apr, 2021
Reviewers agreed
On 01 Apr, 2021
Reviewers agreed
On 19 Mar, 2021
Reviewers invited
Invitations sent on 19 Mar, 2021
Editor assigned
On 17 Mar, 2021
Editor invited
On 10 Mar, 2021
Submission checks complete
On 10 Mar, 2021
First submitted
On 20 Feb, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Introduction:
To analyze the association between human immunodeficiency virus (HIV) infection, and the presence of subclinical atherosclerosis and endothelial dysfunction.
Methods
Prospective cohort study of HIV positive patients who underwent to intimate thickness (IMT) determination and coronary artery calcium score to determine subclinical atherosclerosis. To detect endothelial dysfunction breath holding index, flow mediated dilation and concentration of endothelial progenitor cells (EPC) were measured.
Results
Patients with an IMT ≥ 0.9 mm had an average of 559.3 ± 283.34 CD4/µl and those with an IMT < 0.9 mm 715.4 ± 389.92 CD4/µl (p = 0.04). Patients with a low calcium score had a significantly higher average of CD4 cells value and lower zenith viral load than those with a higher score (707.7 ± 377.5 CD4/µl vs 477.23 ± 235.7 CD4/µl (p = 0.01)) and (7x104 ± 5x104 c/ml vs 23.4 x 104 ± 19 x 104 c /ml (p = 0.02). Early EPCs concentration in patients with a CD4 nadir < 350/ul was lower than concentration among those presenting a CD4 nadir ≥ 350 (p = 0.03).
Conclusion
In HIV positive patients low CD4 cells levels and high viral load were associated to a higher risk of developing subclinical atherosclerosis.HIV patients with less CD4 cells may have fewer early EPCs.
No competing interests reported.
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