Perception and Practice of Self-medication With Antibiotics Among Medical Students in Sudanese Universities: a Cross-sectional Study.

doi:10.21203/rs.3.rs-260575/v1

PDF

Research

Perception and Practice of Self-medication With Antibiotics Among Medical Students in Sudanese Universities: a Cross-sectional Study.

https://doi.org/10.21203/rs.3.rs-260575/v1

This work is licensed under a CC BY 4.0 License

Version 1

posted 03 Mar, 2021

You are reading this latest preprint version

Introduction: The benefits of antibiotics are under threat by self-medication, which culminated in economic burdening of developing countries, treatment failures, the emergence of antibiotic-resistant strains of bacteria and an increased probability of exposure and infection of the general population by antibiotic-resistant bacterial strains.

Objectives: This study aimed to evaluate the knowledge and attitude of medical students in Sudan towards the use of antibiotics, the prevalence of self-medication with antibiotics among medical students in Sudan and to identify risk factors which promote self-medication with antibiotics.

Materials and Methods: This was a cross-sectional, descriptive and institution-based study, between November 2020 and January 2021. 1,110 medical students were selected by multistage cluster sampling. Logistic regression was used to identify risk factors of self-medication with antibiotics among the study participants.

Results: The median knowledge score was 7 out of a maximum of 10 (IQR: 5-8). A moderately positive attitude was observed among the participants (Median: 7/10; IQR: 6-8). 675 (60.8%) self-medicated with antibiotics within the previous 12 months, mostly from community pharmacies (321/675; 47.5%). Antibiotics were most commonly used to treat respiratory tract infections (38.1%) and cough (30.4%). Logistic regression analysis demonstrated that self-medication with antibiotics was significantly associated with gender, year of study and monthly income.

Conclusions: Undergraduate medical students had moderate knowledge and attitude towards antibiotic use and antibiotic resistance, and an alarmingly high prevalence of self-medication with antibiotics. This highlights the urgent need for tighter legislation regarding the sales of antibiotics in community pharmacies by the state and federal health ministries.

Infectious Diseases

General Microbiology

Knowledge

attitude

practice

self-medication

antibiotics

medical students

Sudan

Antibiotics are medications which inhibit the growth of bacteria and are prepared for prevention and treatment of bacterial diseases (1). Since the introduction of antimicrobial agents as part of an essential drugs concept developed by the World Health Organization (WHO) in the 1970s, antibiotic stewardship has played a significant role in improving public health (2,3). These medications are essential treatments in the developing world, particularly where infectious diseases remain a common cause of morbidity and mortality (4). However, in the developing world, the societal, economic and therapeutic benefits of antibiotics have come under threat by self-medication and parent-to-child medication, usually with over-the-counter antibiotics (5–9). Self-medication can be described as the use of medications to treat self-diagnosed disorders or symptoms, or the intermittent use of a prescribed drug for chronic or recurrent diseases or symptoms (10). Various practices of self-medication include the acquisition of these medications without prescription from a certified medical practitioner, reuse of previous prescriptions, use of leftover medications and sharing with family members, neighbours and others (5,11). Reasons for practicing self-medication are unique to each region and can be related to various factors including health systems, location (12), poverty, gender and age (13). In some regions, self-medication is regarded as a gateway to independence from health systems (14) and a means of observing a human right to refuse treatment from physicians (15). Self-medication with antibiotics is directly linked to inappropriate use, such as inadequate dosage, sharing of medications and cessation of treatment with cessation of symptoms (16). This leads to an increased risk of drug interactions, the concealing of symptoms of underlying conditions and the emergence of antibiotic-resistant strains (17). Furthermore, the outcome of improper use of antibiotics has been documented as an increased incidence of water-borne and food-borne infections by antibiotic-resistant bacteria, nosocomial infections and suppressed animal production. As a result of the advent of resistant strains, prolonged hospital stays due to failure of treatment regimens, in conjunction with increased community movement, culminates in a greater risk of the general population to contracting strains of antibiotic-resistant bacteria (18,19). The overall mortality rate of antimicrobial resistance is currently estimated at 700,000 lives per annum and is projected to rise to 10 million lives annually by 2050. In an effort to combat the resultant increase in mortality, the World Health Organization has initiated a global effort to raise awareness of antimicrobial resistance and increase antibiotic stewardship. (20)

In Sudan, studies have shown alarmingly high prevalence rates of self-medication with antibiotics in Khartoum State, with prevalence rates ranging between 41% (21) to 79.5% (22) and the practice being significantly associated with age (21,22) and income (10). Antibiotics in Sudan are readily accessible without the need for prescriptions, with little control of sales by governing bodies, which subsequently leads to an increased economic burdening on state and federal health systems (23–25).

The aim of this study was to investigate the knowledge and attitude of undergraduate medical students in Sudan, in eight universities across five states, towards antibiotic use and antibiotic resistance. Also, this study sought to assess the prevalence of self-medication with antibiotics among the participants, the risk factors which promote practicing self-medication with antibiotics, the most common symptoms treated by antibiotic self-medication and the reasons for practicing self-medication with antibiotics. This study was motivated by the recent change in population movement between various states in Sudan, the absence of data on self-medication with antibiotics at a national level in Sudan and the alarming spread of antibiotic-resistant strains of bacteria through through Sudan, Africa and the Eastern Mediterranean Region.

Study design

This was a descriptive, cross-sectional study conducted in the medical schools of University of Khartoum, Alzaiem Alazhari University, University of Gezira, University of Gadarif, University of Bakht Alruda, National Ribat University, Omdurman Islamic University and Ahfad University for Women between November 2020 and January 2021. The total population of medical students was 12,350 people.

Sampling size and technique

A pilot study was conducted, in which the prevalence of non-prescription antibiotic use was 49%. The calculated sample size was 1,110 medical students according to the mathematical equation below, considering p = 0.49, Z = 1.96 at 95% confidence and N = 12,350.

A multistage cluster sampling technique was applied to proportionally select the participants. In the first stage, medical students from each university were selected. The second stage involved the acquisition of a simple random sample of medical students from each academic year, based on ID numbers registered at the Deanship of Student Affairs in each medical school.

Data Collection Tools and Methods

A closed-ended, pre-validated and pretested questionnaire was used to collect data from the respondents, consisting of 38 questions divided into five sections: Sociodemographic characteristics, Knowledge, Attitude, Practice and Storage.

The first section recorded the socio-demographic characteristics of the respondents including gender, academic year, monthly allowance, health insurance status and relatives working in the health sector.

The knowledge and attitude sections of the questionnaire each contained 10 questions whose responses were measured with a five-point Likert scale. One point was awarded for the correct answer (answering “Agree/Strongly Agree” to correct statements and items of positive attitude and “Disagree/Strongly Disagree” to incorrect statements and items of negative attitude), while no points were awarded for “Not Sure” and the incorrect responses. For quantitative analysis of the responses to knowledge, a score of < 60% was considered poor, 60–80% was considered moderate and ≥ 80% was considered a good score in both sections.

In the practice section of the questionnaire, participants were asked if non-prescription antibiotics were taken within the previous 12 months and obliged to answer five further questions regarding their source, symptoms treated, the reasons for self-medicating with antibiotics and the name of the antibiotics taken. All respondents were required to answer four further questions on how to use antibiotics. The storage section contained three questions on whether antibiotics are stored at home, how often they are stored and where respondents store antibiotics. Responses to these sections were not given a score.

Data Analysis

The data collected was cleaned, analysed and presented using SPSS version 26.0.0 for macOS Catalina. Responses on sociodemographic characteristics were presented using frequency and percentages. As the data on knowledge and attitude scores were not normally distributed, Wilcoxon rank testing was applied to evaluate associations between median scores and the respondents’ characteristics. Chi-square testing was also used to identify risk factors of non-prescription antibiotic use among the participants. A P-value of < 0.05 was considered significant.

Sociodemographic characteristics

The majority of the study population were females (69.2%). 29.7% were fourth-year medical students and 32.4% were receiving monthly allowances of 5,000–10,000 SDG (75–150 USD) per month. Students with health insurance accounted for 49.6%. (Table 1)

Knowledge

A median knowledge score of 7/10 (IQR: 5–8) was achieved by the respondents in this study, thus demonstrating a moderate level of knowledge towards antibiotic use. 329 (29.6%) achieved good knowledge scores, while 484 (43.6%) achieved moderate knowledge scores. 297 (26.7%) of the respondents showed poor knowledge. Median scores were significantly associated with academic year and monthly allowance (P < 0.01; Wilcoxon rank test). 6th-year medical students had significantly higher knowledge on antibiotics than medical students in other years. (Table 1).

The majority of students in this study (943/1110; 84.9%) were aware that repetitive non-compliance with antibiotics leads to antibiotic resistance, while one-fifth (204/1110; 18.3%) incorrectly stated that cold and flu symptoms can be treated with antibiotics. (Table 2)

Table 1

Sociodemographic characteristics of the respondents and median knowledge and attitude scores.
Sociodemographic Characteristics	n (%)	Knowledge score: Median (IQR)	P (Wilcoxon sum test)	Attitude score: Median (IQR)	P (Wilcoxon sum test)
Gender			0.1		0.168
Male	342 (30.8%)	7(5–8)		6(4–8)
Female	768 (69.2%)	7(5–8)		6(5–8)
Academic Year			< 0.001		0.003
First Year	221 (19.9%)	6(5–7)		6(4–8)
Second Year	159 (14.3%)	6(5–6)		6(4–7)
Third Year	206 (18.6%)	7(5–8)		6(4–7)
Fourth Year	330 (29.7%)	7(6–8)		6(5–8)
Fifth Year	143 (12.9%)	7(6–8)		6(5–8)
Sixth Year	51 (4.6%)	8(7–9)		7(6–8)
Monthly Allowance			0.046		0.002
< 5,000 SDG	290 (26.1%)	6.5(5–8)		6(5–7)
5,000–10,000 SDG	360 (32.4%)	7(6–8)		6(5–8)
10,000–15,000 SDG	209 (18.9%)	6(6–8)		7(5–8)
> 15,000 SDG	251 (22.6%)	7(5–8)		6(5–8)
Family members in the health field			< 0.001		0.009
Yes	691 (62.3%)	6(5–8)		6(5–8)
No	419 (37.7%)	7(5–8)		6(5–7)
Health insurance			0.137		0.096
Yes	551 (49.6%)	6(5–8)		6(5–8)
No	559 (50.4%)	7(6–8)		6(5–8)

Table 2

Responses to questions related to knowledge (n = 1,110)
	Strongly Disagree: n (%)	Disagree: n (%)	Not Sure: n (%)	Agree: n (%)	Strongly Agree: n (%)
Antibiotics can be used to treat cold and flu symptoms. .	561 (50.5%)	148 (13.3%)	197 (17.7%)	76 (6.8%)	128 (11.5%)
Antibiotics should not be purchased without prescriptions.	122 (11.0%)	68 (6.1%	139 (12.5%)	156 (14.1%)	625 (56.3%)
It is safe to use any antibiotic during pregnancy.	619 (5.8%)	214 (19.3%)	215 (19.4%)	47 (4.2%)	15 (1.4%)
Antibiotics will always be effective in treating the same diseases in future.	640 (57.7%)	257 (23.2%)	88 (7.9%)	61 (5.5%)	64 (5.8%)
Allergic reactions can occur from using antibiotics.	22 (2.0%)	65 (5.9%)	164 (14.8%)	253 (22.8%)	606 (54.6%)
Different infections require separate antibiotic treatment regimens.	214 (19.3%)	81 (7.3%)	214 (19.3%)	271 (24.4%)	330 (29.7%)
Antibiotics can be used to treat bilharziasis.	394 (35.5%)	160 (14.4%)	319 (28.7%)	119 (10.7%)	118 (10.6%)
Most sore throats are treated with antibiotics.	275 (24.8%)	182 (16.4%)	303 (27.3%)	222 (20.0%)	128 (11.5%)
It is preferable to use broad-spectrum antibiotics under all circumstances.	404 (36.4%)	221 (19.9%)	260 (23.4%)	144 (13.0%)	81 (7.3%)
Repetitive non-compliance with antibiotic courses may lead to antibiotic resistance.	19 (1.7%)	31 (2.8%)	117 (10.5%)	167 (15.0%)	776 (70.0%)

Attitude

The median attitude score achieved by medical students in this study was 7/10 (IQR: 6–8). Wilcoxon rank testing depicted that attitude scores varied significantly among the participants according to academic year, monthly allowance and having relatives in the health field (P < 0.01). (Table 1). Over three-fifths of medical students (63.6%) would ask their pharmacist or physician for antibiotics, while 14.1% held the misconception that more expensive antibiotic regimens had less side effects (Table 3).

Table 3

Responses to questions related to attitude (n = 1,110)
	Strongly Disagree n (%)	Disagree n (%)	Not Sure n (%)	Agree n (%)	Strongly Agree n (%)
I believe it is better to self-medicate with antibiotics for minor illnesses than to see a doctor.	453 (40.8%)	200 (18.0%)	173 (15.6%)	148 (13.3%)	136 (12.3%)
I would only purchase antibiotics with a valid prescription.	140 (12.6%)	117 (10.5%)	232 (20.9%)	201 (18.1%)	420 (37.8%)
I believe that more expensive antibiotics have fewer side effects.	505 (45.5%)	196 (17.7%)	253 (22.8%)	102 (9.2%)	54 (4.8%)
I would stop my treatment with antibiotics when my sumptoms stop.	727 (65.5%)	144 (13.0%)	102 (9.2%)	49 (4.4%)	88 (7.9%)
I would use antibiotics for the same reasons as paracetamol.	579 (52.2%)	226 (20.3%)	191 (17.2%)	64 (5.8%)	50 (4.5%)
I prefer to be prescribed intravenous antibiotics.	462 (41.6%)	243 (21.9%)	302 (27.2%)	66 (5.9%)	37 (3.3%)
I would use antibiotics to treat malaria.	260 (23.4%)	183 (16.5%)	314 (28.3%)	179 (16.1%)	174 (15.7%)
I believe it is important to read the leaflet provided.	19 (1.7%)	34 (3.1%)	132 (11.9%)	213 (19.2%)	712 (64.1%)
I agree that antibiotic resistance can occur from inappropriate use.	68 (6.1%)	36 (3.2%)	172 (15.5%)	145 (13.1%)	689 (62.1%)
I would ask my pharmacist or doctor for antibiotics.	116 (10.5%)	76 (6.8%)	212 (19.1%)	203 (18.3%)	503 (45.3%)

Practice

Of the 1,110 medical students, 675 (60.8%) had self-medicated with antibiotics within the previous 12 months (Table 4). Chi-square testing demonstrated that the use of non-prescription antibiotics was significantly associated with gender (P < 0.01), monthly allowance (P = 0.011) and academic year (P < 0.02). Logistic regression analysis also depicted that females were 1.52 times more likely to self-medicate with antibiotics than males (95% CI: 1.16–1.99). Medical students without relatives working in the health field were less likely to use non-prescription antibiotics (OR: 0.83; 95% CI: 0.65–1.07).

The most common source of non-prescribed antibiotics in this study was community pharmacies (47.5%), followed by personally-known physicians (46.1%) (Table 5)

The most common antibiotic used without prescription in this study was found to be azithromycin (202/675; 29.9%), followed by amoxicillin/clavulanic acid (181/675; 26.8%) and erythromycin (87/675; 12.9%). Over one-quarter of the respondents did not recall the antibiotics taken prior to the study (Table 6). The most common symptoms treated with non-prescription antibiotics were upper respiratory tract symptoms (257/675; 38.1%), followed by cough (205/675; 30.4%) and common cold (177/675; 26.2%).

Table 4

Sociodemographic characteristics of the respondents and self-medication with antibiotics.
Sociodemographic Characteristics	Total (n = 1,110)	Self-medicated with antibiotics (n = 675)	OR	95% CI	P
Gender					0.002
Male	342	231	1	-
Female	768	444	1.52	1.16–1.99
Academic Year					0.002
First Year	221	127	1	-
Second Year	159	81	1.3	0.86–1.96
Third Year	206	127	0.84	0.57–1.24
Fourth Year	330	226	0.62	0.44–0.89
Fifth Year	143	89	0.82	0.53–1.26
Sixth Year	51	25	1.41	0.76–2.59
Monthly Allowance					0.011
< 5,000 SDG	290	183	1	-
5,000–10,000 SDG	360	194	1.46	1.07–2.01
10,000–15,000 SDG	209	142	0.81	0.55–1.18
> 15,000 SDG	251	156	1.04	0.73–1.48
Family members in the health field					0.155
Yes	691	409	1	-
No	419	266	0.83	0.65–1.07
Health insurance					0.533
Yes	551	330	1	-
No	559	345	0.93	0.73–1.18

Table 5

Sources of non-prescription antibiotics (n = 675)
Source of non-prescription antibiotics (n = 675)	n (%)
Community pharmacies	321 (47.5%)
Personally-known physicians	311 (46.1%)
Friends from abroad	24 (3.6%)
Neighbours	15 (2.2%)
Other	4 (0.6%)

It was found that over three-fifths (682/1110; 61.4%) carefully read the leaflet provided, while 44.3% (492/1110) always complete the course of antibiotics (Table 7).

Table 6

Non-prescription antibiotics used by the respondents and symptoms treated with non-prescription antibiotics (n = 675)
Name of antibiotic	n = 675	%
Azithromycin	202	29.9%
Amoxicillin/clavulanic acid	181	26.8%
Erythromycin	87	12.9%
Ciprofloxacin	43	6.4%
Cefixime	31	4.6%
Metronidazole	19	2.8%
Clarithromycin	17	2.5%
Clindamycin	15	2.2%
Cephalexin	14	2.1%
Levofloxacin	12	1.8%
Other	24	3.6%
Unknown antibiotic	195	28.9%
Symptoms treated with non-prescription antibiotics.
Respiratory tract symptoms.	257	38.1%
Cough.	205	30.4%
Common cold.	177	26.2%
Abdominal pain.	99	14.7%
Urinary tract symptoms.	92	13.6%
Malaria.	26	3.9%
Ear infections.	24	3.6%
Sore throat.	45	6.7%
Wounds	8	1.2%
Other.	30	4.4%

The major reason cited by the respondents for self-medicating with antibiotics was previous experiences with similar symptoms (335/675; 49.6%). Costly appointments were also common reason to practice antibiotic self-medication in this study (138/675; 20.4%). (Table 7) When using antibiotics, over three-fifths (682/1110; 61.1%) carefully read the leaflet before consumption. 25.0% (278/1110) of the respondents always store antibiotics at home for future use. (Table 8) Over two-thirds (759/1110; 68.4%) stored antibiotics during the study. Logistic regression analysis demonstrated that self-medication with antibiotics was significantly associated with storage (P < 0.001) (Table 9).

Table 7

Reasons for self-medicating with antibiotics (n = 675)
	n	%
Previous experience with similar symptoms	335	49.6%
Costly doctor’s appointments	138	20.4%
No waiting	177	26.2%
Non-expert recommendations	31	4.6%
Leftover antibiotics at home	61	9.0%
Other	43	6.4%

Table 8

Practice of antibiotic use and storage of antibiotics (n = 1,110)
	Never n (%)	Sometimes n (%)	Always n (%)
Practice
I complete the course of antibiotics.	78 (7.0%)	540 (48.6%)	492 (44.3%)
I carefully read the leaflet provided.	59 (5.3%)	369 (33.2%)	682 (61.4%)
I experience effects when taking antibiotics.	587 (52.9%)	442 (39.8%)	81 (7.3%)
When using intravenous antibiotics, I administer them myself.	978 (88.1%)	108 (9.7%)	24 (2.2%)
Storage
How often do you store antibiotics at home?	160 (14.4%)	672 (60.5%)	278 (25.1%)

Table 9

Self-medication and storage storage of antibiotics
Are antibiotics stored in the home?	Total n (%)	Self-medicated with antibiotics n = 675	P
Yes	759 (68.4%)	488	< 0.001
No	351 (31.6%)	187	< 0.001

Medical education before graduation about antimicrobial resistance is one of the important sources that increase their knowledge about antibiotics. Subjects such as pathology courses, pharmacology, clinical pharmacy, and microbiology are opportune for antibiotic and antimicrobial resistance education. The medical curricula of various universities that increases student knowledge and backgrounds about AMR was not available to be assessed. However, this study sought to investigate medical students’ knowledge about antibiotics and antimicrobial resistance including the secondary aim to evaluate possible differences in their attitude and practice outcomes.

Our findings in this study showed that 329 (29.6%) and 484 (43.6%) of medical students appeared to have good and moderate knowledge about antibiotics respectively, while 297 (26.7%) of medical students in this study had poor knowledge. Studies in southeast Asia and Italy have also shown significantly higher knowledge about antibiotics among final-year allied health students (1,2). It has also been stated that poor knowledge may lead to inappropriate antibiotics consumption which can result in a corresponding increase in bacterial resistance antibiotics (3).

Our study finds that there was a difference between medical students in clinical science years (seniors) and those in their initial basic science (juniors) years when it comes to their knowledge about antibiotic resistance. The results of this study identified that senior students have significantly better knowledge scores when compared to juniors (P < 0.001), which concurs with the findings in a study among pharmacy students in Sri Lankan universities (4). Our results support that medical students from various areas, universities and backgrounds are aware about the growing global problem of antimicrobial resistance stated by the current evidence(3,5). A recent cross-sectional study in 29 European countries in 2018 discovered that medical students still need more education about the proper use of antibiotics for their future practice (6).

The majority (63.6%) held the misconception that antibiotics can be requested from healthcare providers during consultations. Patient request and coercion has proven to influence the prescription behaviour of healthcare providers, especially in the absence of continuing education and external responsibility. These factors greatly influence the dispensing behaviour among physicians, with malpractice being more common among healthcare providers expressing their refusal to communicate effectively with patients, in order to achieve time-effectiveness (10,21,32). In Tanzania, 25.5% also preferred use of non-prescription antibiotics for minor illnesses as opposed to consulting doctors. This has been cited as a common reason for antibiotic self-medication in Namibia (33,34).

Similar to a study conducted in UAE, a considerable proportion of final year medical students demonstrated a positive attitude to antibiotic use (35). Academic seniority was also significantly associated with attitude scores (P < 0.01), with first-to-third year students achieving lower scores. Antibiotic resistance is not given sufficient cover in medical curricula in Sudan, while liberal practice of antibiotic use may be motivated by the acquisition of tuition in pharmacology and infectious diseases during this period. These findings are consistent with a previous study in China, where third-year medical students achieved the lowest attitude scores. (36).

Our results in this study have shown that the prevalence of self-medication with antibiotics within the previous 12 months among medical students in Sudan is 60.8%, which is a very high rate. Such results are not uncommon in Sudan as similar trends have been observed in previous studies among undergraduate students and the general population in Khartoum State (10,21,32). In Africa and the Eastern Mediterranean regions, this trend is also not unique to Sudan. Several studies on self-medication with antibiotics in both regions have portrayed similar and higher prevalence rates. In the African region, a study in northeastern Tanzania has shown that the prevalence of self-medication with antibiotics is 58%, while in Namibia, a study conducted on antibiotic self-mediation among children with acute respiratory infections depicted a prevalence rate of 60%. In rural Nigeria, a considerably higher prevalence rate (82.2%) was observed. (33,34,37)

In the Eastern Mediterranean region, studies in UAE and Saudi Arabia reported prevalence rates of 52.1% and 78.8% respectively. (38,39)

Many significant predictors of self-medication among undergraduate medical students in Sudan were identified in this study. Females were significantly more likely to use non-prescription antibiotics than males in this study (p < 0.01). Previous studies in Khartoum State (10,21), also reported self-medication with antibiotics being higher among females. This was also a common finding in multiple studies across Africa. In studies conducted among university students in Ethiopia and Nigeria (37, 40–42), female gender was also a significant determinant of self-medication with antibiotics. This could be due to the practice of sharing various types of medications being higher among females, although this requires confirmation through further studies.

Monthly allowance was also found to be a predictor of antibiotic self-medication in this study (p = 0.011). In lower-middle-income and low-income countries, low income may force individuals to search ways for decreased expenditure associated with access to healthcare, often by avoiding consultations with primary care and specialist physicians (43). The development of health systems capable of providing healthcare to the population without financial hardship, in conjunction with a regulatory framework on antibiotic use would thus be crucial in combating the emergence of antibiotic-resistant strains resulting from the irrational use of antibiotics. (44)

The results of this study indicated that the most commonly used antibiotics to practice self-medication were azithromycin (29.9%) and amoxicillin/clavulanic acid (26.8%). Amoxicillin/clavulanic acid was also among the most popular antibiotics used for self-medication in Ethiopia (40) and Eritrea (45). Amoxicillin/clavulanic acid is widely prescribed by healthcare providers worldwide, inexpensive and is considered as first-line therapy in many lower-middle-income and low-income countries where infectious diseases are highly prevalent (46). In this study, azithromycin was the most popular antibiotic - a finding which was not observed in previously conducted studies in Sudan (10,21,32,46). This change may be due to the resistance of bacterial strains as a result of over-prescription and misuse amoxicillin/clavulanic acid. Amoxicillin/clavulanic acid is commonly sold in pharmacies as Amoclan in Sudan. Amoclan is effective in treatment of infections caused by Klebsiella and Escherichia coli. However, resistant strains have emerged as a result of its overuse (47,48). This may also be explained by clients and patients requesting more potent antibiotics from their pharmacies. The use of higher-potency antibiotics also suggests that pharmacists and physicians may inform their patients about infections resistant to certain antibiotics, while patients use this information independently after their consultations. Azithromycin was also commonly prescribed in Mozambique and India (49,50). 195 respondents used unknown antibiotics, with unknown dosage and course durations. Incomplete courses and indiscriminate drug use increase the risk of side effects rom polypharmacy and the emergence of antibiotic-resistant strains (10,51,52)

The most common symptoms treated with non-prescription antibiotics were acute respiratory tract symptoms (38.1%), cough (30.4%) and common cold (26.2%). These ailments do not usually require antibiotic treatment and the practice of non-prescription antibiotic use for their treatment is a global commonality (53–62). In accordance with the response of the World Health Organization to the global crisis of antimicrobial crisis, a universal protocol regarding antibiotic prescription is adopted by clinicians. Bacteria are the only class of organisms against which antibiotics have any effect, with infection by different strains of bacteria requiring treatment with different antibiotics. It is on these grounds that only a fully qualified healthcare provider is given the right to decide which antibiotic is used in particular bacterial infections, after thorough clinical assessment of each patient, in accordance which local and national guidelines. These policies promote patient safety and safer, more economical utilisation of antibiotics among both prescribers and patients (63–65). If the public were to be aware of these policies, the practice of self-medication with antibiotics would likely be discouraged. A one-health approach should therefore be applied in an effort to raise awareness and share information regarding the correct protocol of antibiotic use, which would lead to the making of more informed decisions regarding the use of non-prescription antibiotics.

Of the 675 respondents who practiced non-prescription antibiotic use, 47.5% sought these medications from community pharmacies, while 9.0% used leftover antibiotics. This pattern remains consistent in Sudan (10,21,32,46) and thus demonstrates laxity within its health system in prohibition of sales of antibiotics without valid prescriptions. Similar experiences also motivated 49.6% to use nonprescription antibiotics as a cost-effective option. This trend can be combated by enacting policies prohibiting the inappropriate sales in private pharmacies and maintaining supplies in hospital pharmacies and public health facilities. In low-income countries, low supplies of essential drugs in hospital pharmacies may drive patients to pay higher prices in private pharmacies (66). The enactment of policies prohibiting irrational sales of antibiotics can lead to considerably lower antibiotic self-mediation rates, thus proving beneficial in combating antimicrobial resistance (67,68). Leftover antibiotics are among the most frequently stored antibiotics in low-income countries, indicating frequent non-compliance with the course of anti-infective treatment in conjunction with an increased risk of sharing (69).

The authors acknowledge that this study is not without limitations. As this is a retrospective questionnaire-based study, the results of the study are entirely dependent on the responses given by the participants and are therefore influenced by recall bias. Also, the questionnaire itself was administered online due to high travel expenses amid a difficult political climate. Despite these barriers, given the applied sampling technique, the authors believe that the results give an appropriate portrayal of knowledge and attitude towards antibiotic use and antibiotic resistance, paired with an accurate estimate of self-medication with antibiotics among medical students in Sudan.

In this study, undergraduate medical students in Sudan demonstrated moderate levels of knowledge and attitude towards antibiotics. The prevalence of self-medication with antibiotics is very high among Sudanese medical students, with community pharmacies being a popular source of non-prescription antibiotics. Policy reform and legislation to regulate sales of antibiotics as prescription-only medications and revision of content on antimicrobial resistance in medical curricula in Sudan are therefore crucial in addressing antibiotic misuse and improving knowledge and attitude towards antibiotic use among medical students.

Ethics.

Ethical clearance was obtained from the Medical Research Ethics Committee of the Faculty of Medicine and Health Sciences, University of Gadarif. The objectives of the study, beneficence and non-maleficence were explained to the respondents prior to obtaining informed consent to participate in our study.

Acknowledgement.

We acknowledge all the respondents for their time in participating in this study.

Funding.

This study was funded independently by the authors.

Transparency declarations.

None to declare.

Conflict of Interest.

None declared among the authors.

Availability of data and materials.

The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.

Author Contributions.

Osman K.O. Elmahi and Reem A.E. Musa designed the study and performed the literature review. All authors collected and analysed the data, wrote the manuscript and approved the final manuscript.

Ayukekbong, J.A.; Ntemgwa, M.; Atabe, A.N. The threat of antimicrobial resistance in developing countries: Causes and control strategies. Resist. Infect. Control 2017, 6, 47.
le Grand A, Hogerzeil HV, Haaijer-Ruskamp FM, Intervention research in rational use of drugs: a review. Health Policy Plan, 1999, 14: 89-102
Wise R., Antimicrobial resistance: priorities for action, 2001, J Antimicrob Chemother, 49: 585-6.
World Health Organization. Health Organization. Geneva : World Health Organization: [Mar;2018 ]. 2008. Health statistics and information systems. The global burden of disease: 2004 Update.
Loyola Filho, A.I.; Lima-Costa, M.F.; Uchôa, E. Bambuí Project: A qualitative approach to self-medication. Cad. Saude Publica 2004, 20, 1661–1669.
Elong Ekambi G-A, Okalla Ebongue C, Penda IC, Nnanga Nga E, Mpondo Mpondo E, Eboumbou Moukoko CE (2019) Knowledge, practices and attitudes on antibiotics use in Cameroon: Self-medication and prescription survey among children, adolescents and adults in private pharmacies. PLoS ONE 14(2): e0212875. https://doi.org/10.1371/journal.pone.0212875
Högberg LD, Muller A, Zorzet A, Monnet DL, Cars O, Antibiotic use worldwide, Lancet Infect Dis. 2014 Dec; 14(12):1179-80.
Morgan DJ, Okeke IN, Laxminarayan R, Perencevich EN, Weisenberg S. Non-prescription antimicrobial use worldwide: a systematic review. Lancet Infect Dis. 2011;11(9):692-701. doi:10.1016/S1473-3099(11)70054-8
Escourrou B., Bouville B., Bismuth M., Durrieu G., Oustric S. Child self-medication by parents: a real risk? Revue du praticien. 2010; 60(Sup 1):34–36
Awad, AI , Eltayeb, IB , Capps, PAG . Self-medication practices in Khartoum State, Sudan. Eur J Clin Pharmacol 2006; 62:317–24.
Shehnaz SI, Agarwal AK, Khan N, A systematic review of self-medication practices among adolescents, J Adolescent Health, 2014, 55(4): 467-483
Ehigiator, O.; Azodo, C.C.; Ehizele, A.O.; Ezeja, E.B.; Ehigiator, L.; Madukwe, I.U. Self-medication practices among dental, midwifery and nursing students. Eur. J. Gen. Dent. 2013, 2, 54–57
Ocan, M; Obuku, EA; Bwanga, F; Akena, D; Richard, S; Ogwal-Okeng, J; Obua, C, "Household antimicrobial self-medication: a systematic review and meta-analysis of the burden, risk factors and outcomes in developing countries", 2015, BMC Public Health. 15: 742. doi:10.1186/s12889-015-2109-3
Hughes, C.M., McElnay, J.C., Fleming, G.F. Benefits and Risks of Self Medication, 2001, Drug-Safety 24, 1027–1037. https://doi.org/10.2165/00002018-200124140-00002
Flanigan J Three arguments against prescription requirements Journal of Medical Ethics 2012;38:579-586.
World Health Organization. Geneva : World Health Organization. Geneva : World Health Organization: [Mar;2018 ]. 2009. Community-Based Surveillance of Antimicrobial Use and Resistance in Resource-Constrained Settings: Report on Five Pilot Projects.
Spellberg B, Guidos R, Gilbert D, Bradley J, Boucher HW, Scheld WM, Bartlett JG, Edwards J Jr, The epidemic of antibiotic-resistant infections: a call to action for the medical community from the Infectious Diseases Society of America, 2008, Clin Infect Dis, 46(2):155-64.
Zdziarski P, Simon K, Majda J. Overuse of high stability antibiotics and its consequences in public and environmental health. Acta Microbiol Pol. 2003;52(1):5-13.
WHO,Fact sheet N°194 (2002) Antimicrobial resistance.
Williams, D.N. Antimicrobial resistance: Are we at the dawn of the post-antibiotic era? 2016, J. R. Coll. Physicians Edinb, 46, 150–156.
Elhada AHA, Eltayeb IB, Mudawi MME, Pattern of self-medication with antibiotics in Khartoum State, Sudan, World J Pharm Res, 2014;3(5):678-692.
Awad AI, Eltayeb IB. Self-Medication Practices with Antibiotics and Antimalarials Among Sudanese Undergraduate University Students. Annals of Pharmacotherapy. 2007;41(7-8):1249-1255.
Yadav S, Rawal G. Self-medication practice in low income countries. Int J Pharmaceut Chem Anal. 2015;2(3):139–142.
Auta A, Omale S, Folorunsho TJ, David S, Banwat SB. Medicine vendors: Self-medication practices and medicine knowledge. N Am J Med Sci. 2012; 4(1):24–28. DOI: 10.4103/1947-2714.92899
Thapa K, Bhattachan B, Gurung RR, Katuwal A, Khadka JB. Antibiotic resistance pattern of Shigella spp. among gastroenteritis patients at Tertiary Care Hospital in Pokhara, Nepal. Nepal Journal of Biotechnology. 2017;5(1):14-20.
Jairoun A, Hassan N, Ali A, Jairoun O, Shahwan M. Knowledge, attitude and practice ofantibiotic use among university students: A cross sectional study in UAE. BMC Public Health. 2019;19(1):1–8.
Dhingra S, Khan M, Maharaj S, Pandey S, Patel I, Ahmad A. Knowledge, attitude and practice of B.Sc. Pharmacy students about antibiotics in Trinidad and Tobago. J Res Pharm Pract. 2015;4(1):37.
Okedo-Alex I, Madubueze UC, Umeokonkwo CD, Oka OU, Adeke AS, Okeke KC. Knowledge of antibiotic use and resistance among students of a medical school in Nigeria. Malawi Med J. 2019;31(2):133–7.
Sakeena MHF, Bennett AA, Jamshed S, Mohamed F, Herath DR, Gawarammana I, et al. Investigating knowledge regarding antibiotics and antimicrobial resistance among pharmacy students in Sri Lankan universities. BMC Infect Dis. 2018;18(1):1–11.
Dyar OJ, Hills H, Seitz LT, Perry A, Ashiru-Oredope D. Assessing the knowledge, attitudes and behaviors of human and animal health students towards antibiotic use and resistance: a pilot cross-sectional study in the UK. Antibiotics. 2018;7(1):1–8.
Assar A, Abdelraoof MI, Abdel-Maboud M, Shaker KH, Menshawy A, Swelam AH, et al. Knowledge, attitudes, and practices of Egypt’s future physicians towards antimicrobial resistance (KAP-AMR study): a multicenter cross-sectional study. Environ Sci Pollut Res. 2020;27(17):21292–8.
Awad AI, Eltayeb IB. Self-Medication Practices with Antibiotics and Antimalarials Among Sudanese Undergraduate University Students. Annals of Pharmacotherapy. 2007;41(7-8):1249-1255. doi:10.1345/aph.1K068
Horumpende PG, Said SH, Mazuguni FS, Antony ML, Kumburu HH, Sonda TB, et al., Prevalence, determinants and knowledge of antibacterial self-medication: A cross sectional study in North-eastern Tanzania, 2018, PLoS ONE 13(10): e0206623. https://doi.org/10.1371/journal.pone.0206623
Kamati M, Godman B, Kibuule D. Prevalence of Self-Medication for Acute Respiratory Infections in Young Children in Namibia: Findings and Implications. J Res Pharm Pract. 2019 Dec 27;8(4):220-224. doi: 10.4103/jrpp.JRPP_19_121.
Jairoun A, Hassan N, Ali A. et al. Knowledge, attitude and practice of antibiotic use among university students: a cross sectional study in UAE. BMC Public Health 2019;19:518 https://doi.org/10.1186/s12889-019-6878-y
Lv B, Zhou Z, Xu G, Yang D, Wu L, Shen Q, Jiang M et al., Knowledge, attitudes and practices concerning self‐medication with antibiotics among university students in western China. Trop Med Int Health, 2014;19:769-779. https://doi.org/10.1111/tmi.12322
Abdulraheem IS, Adegboye A, Fatiregun AA. Self-medication with Antibiotics: Empirical Evidence from a Nigerian Rural Population. JPRI, 2016;11(5):1-3. Available from: https://www.journaljpri.com/index.php/JPRI/article/view/186197.
Sridhar SB, Shariff A, Dallah L, Anas D, Ayman M, Rao PG. Assessment of Nature, Reasons, and Consequences of Self-medication Practice among General Population of Ras Al-Khaimah, UAE. Int J Appl Basic Med Res. 2018 Jan-Mar;8(1):3-8. doi: 10.4103/ijabmr.IJABMR_46_17.
Rasheed A.A., Yagoub U., Alkhashan H., Abdelhay O., Alawwad A., Aboud A.A., Battah S.A., Prevalence and Predictors of Self-Medication With Antibiotics inAl Wazarat Health Center, Riyadh City, KSA, 2016, BioMed Research International; 1-8, https://doi.org/10.1155/2016/3916874.
Gelayee DA, Self-Medication Pattern among Social Science University Students in Northwest Ethiopia, Journal of Pharmaceutics, 2017, 1-5. https://doi.org/10.1155/2017/8680714
Osemene KP and Lamikanra A, A study of the prevalence of self-medication practice among university students in southwestern Nigeria, Trop J Pharm Res, 2012;11(4):683-9.
Gutema GB, Gadisa DA, Kidanemariam ZA, Berhe DF, Berhe AH, Hadera MG, et al. Self-medication practices among health sciences students: The case of Mekelle University. J Appl Pharm Sci 2011;1:183-9.
Alhomoud F, Aljamea Z, Almahasnah R, Alkhalifah K, Basalelah L, Alhomoud FK, Self-medication and self-prescription with antibiotics in the Middle East—do they really happen? A systematic review of the prevalence, possible reasons, and outcomes, Int J inf Dis, 2017;57:3-12 https://doi.org/10.1016/j.ijid.2017.01.014
Chokshi A, Sifri Z, Cennimo D, Horng H. Global Contributors to Antibiotic Resistance. J Glob Infect Dis. 2019 Jan-Mar;11(1):36-42. doi: 10.4103/jgid.jgid_110_18.
Ateshim, Y., Bereket, B., Major, F. et al. Prevalence of self-medication with antibiotics and associated factors in the community of Asmara, Eritrea: a descriptive cross sectional survey. 2019, BMC Public Health 19, 726. https://doi.org/10.1186/s12889-019-7020-x
Elmahi OKO, Balla SA, Khalil HA. Self-Medication with Antibiotics and Its Predictors among the Population in Khartoum Locality, Khartoum State, Sudan in 2018, Int J Trop Dis and Health, 2020;41(4):17-25. Available from: https://www.journalijtdh.com/index.php/IJTDH/article/view/30267.
Beytur A,Yakupogullari Y,Oguz F,Otlu B,Kaysadu H, Oral amoxicillin-clavulanic acid treatment in urinary tract infections caused by extended-spectrum Beta-lactamase-producing organisms, Jundishapur Journal of Microbiology, 2014;8(1):e13792
Abduzaimovic A, Aljicevic M, Rebic V, Vranic SM, Abduzaimovic K, Sestic S, Antibiotic resistance in urinary isolates of Escherichia coli, Materia Socio-Medica, 2016;28(6):416.
Torres NF, Solomon VP, Middleton LE Identifying the commonly used antibiotics for self-medication in urban Mozambique: a qualitative study BMJ Open 2020;10:e041323. doi: 10.1136/bmjopen-2020-041323
Kotwani A, Wattal C, Joshi PC, et al. Irrational use of antibiotics and role of the pharmacist: an insight from a qualitative study in New Delhi, India. J Clin Pharm Ther 2012;37:308–12.
Chalker J. Improving antibiotic prescribing in Hai Phong Province, Viet Nam: the ‘antibiotic-dose’ indicator. Bull World Health Organ 2001;79:313–20.
World Health Organization. Global strategy for containment of antimicrobial resistance: communicable disease surveillance and response (CSR). Geneva: World Health Organization.
Ajayi I. Self medication practices among patients seen in a suburban tertiary eye care centre in Nigeria, 2014.
Alhomoud F, Aljamea Z, Almahasnah R, et al. Self-medication and self-prescription with antibiotics in the Middle East-do they really happen? A systematic review of the prevalence, possible reasons, and outcomes. Int J Infect Dis 2017;57:3–12.
Zhu X, Pan H, Yang Z, et al. Self-medication practices with antibiotics among Chinese university students. Public Health 2016;130:78–83.
Ngigi CK, Mwagiru P, Wala J. Self-medication with antibiotics prior to seeking treatment among adult patients attending outpatient department at gatundu sub-county hospital, Kiambu County, Kenya. Imp J Interdiscip Res 2016;2.
Gajdács M, Paulik E, Szabó A. Knowledge, attitude and practice of community pharmacists regarding antibiotic use and infectious diseases: a cross-sectional survey in Hungary (KAPPhA-HU). Antibiotics 2020;9:41.
Aslam A, Gajdács M, Zin CS, et al. Public awareness and practices towards self-medication with antibiotics among the Malaysian population. A development of questionnaire and pilot-testing. Antibiotics 2020;9:97.
Alrasheedy AA, Alsalloum MA, Almuqbil FA, et al. The impact of law enforcement on dispensing antibiotics without prescription: a multi-methods study from Saudi Arabia. Expert Rev Anti Infect Ther 2020;18:87–97.
Zapata-Cachafeiro M, Piñeiro-Lamas M, Guinovart MC, et al. Magnitude and determinants of antibiotic dispensing without prescription in Spain: a simulated patient study. J Antimicrob Chemother 2019;74:511–4.
Torres NF, Chibi B, Middleton LE, et al. Evidence of factors influencing self-medication with antibiotics in low and middle- income countries: a systematic scoping review. Public Health 2019;168:92–101.
Jakupi A, Raka D, Kaae S, et al. Culture of antibiotic use in Kosovo - an interview study with patients and health professionals. Pharm Pract 2019;17:1540.21.
WHO. Global action plan on antimicrobial resistance. Geneva: Google Scholar, 2015.
WHO. Worldwide country situation analysis: response to antimicrobial resistance: summary. Geneva: World Health Organization, 2015.
WHO. Assessing non-prescription and inappropriate use of antibiotics: report on survey, 2019.
Torres, N.F., Solomon, V. & Middleton, L.E. Patterns of self-medication with antibiotics in Maputo City: a qualitative study, 2019, Antimicrob Resist Infect Control 8, 161. https://doi.org/10.1186/s13756-019-0618-z
Bavestrello L, Cabello A, Casanova D. Impacto de medidas regulatorias en la tendencia de consumo comunitario de antibióticos en Chile [Impact of regulatory measures in the trends of community consumption of antibiotics in Chile]. Rev Med Chil. 2002;130(11):1265-1272.
Santa-Ana-Tellez Y., Mantel-Teeuwisse A.K., Dreser A., Leufkens H.G.M., Wirtz V.J., Impact of Over-The-Counter Restrictions on Antibiotic Consumption in Brazil and Mexico, PLoS One, 2013;8(10):1-6.
Chacko CT, Prakash D, Hafsa P et.al. A review on the attitude and practice on self medication, storage and disposal of drugs in a community, International Journal of Research and Review, 2020;7(8):122-129.

PDF

Version 1

posted 03 Mar, 2021

You are reading this latest preprint version

Perception and Practice of Self-medication With Antibiotics Among Medical Students in Sudanese Universities: a Cross-sectional Study.

Status:

Version 1

Abstract

Introduction

Methodology

Study design

Sampling size and technique

Data Collection Tools and Methods

Data Analysis

Results

Sociodemographic characteristics

Knowledge

Attitude

Practice

Discussion

Conclusions

Declarations

References

Status:

Version 1