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Research
Alireza Sedaghat
Mashhad University of Medical Sciences
Corresponding Author
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Purpose: The objective of this systematic review was to evaluate the effect of pre-, pro-, and synbiotics on feeding tolerance of enterally-fed critically ill adult patients.
Methods: Medline, Science Direct, Web of Knowledge, and the Cochrane Central Register of Controlled Trials were searched up to November 2019. English language randomized controlled trials reporting the effect of pre, pro or synbiotics on the feeding tolerance of enterally-fed critically ill adult patients were included.
Results: Overall, 15 papers were selected for review. Among six studies reporting the energy intake, only two studies showed significantly higher energy intake in the prebiotic-receiving groups. Among four RCTs reporting frequency or time to achieve the target calorie, only one found a significant effect of probiotics to reduce the time to achieve a target dose of calorie. About the prevalence or duration of diarrhea, 7 out of 12 RCTs reported a beneficial effect. All but one study found no beneficial effects for gut microbiota manipulation on clinical endpoints including length of stay (LOS) in hospital and intensive care unit (ICU).
Conclusion: It should be noticed that the heterogeneity in study designs, product format, and ICU patient populations makes it difficult to draw any general conclusion. Overall, it seems that pre, pro or synbiotics have not significant beneficial effect on feeding tolerance and clinical endpoints in critically ill adults, but they may reduce the prevalence or duration of diarrhea.
Keywords
prebiotics, probiotics, synbiotics, gut microbiota, feeding tolerance, critical care
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CURRENT STATUS: Published
View the published article at Systematic Reviews.
No community comments so far
Editorial decision: Major revision
On 21 Feb, 2021
Editor assigned
On 25 Dec, 2020
Submission checks complete
On 25 Dec, 2020
Editor invited
On 25 Dec, 2020
Version 2
Posted 15 Oct, 2020
No comments provided
Review #1 received
Received 28 Oct, 2020
Review #2 received
Received 19 Oct, 2020
Reviewer #2 agreed
On 15 Oct, 2020
Reviewer #1 agreed
On 14 Oct, 2020
Reviewers invited
Invitations sent on 12 Oct, 2020
Editor assigned
On 07 Oct, 2020
Submission checks complete
On 06 Oct, 2020
Editor invited
On 06 Oct, 2020
No comments provided
Editorial decision: Major revision
On 04 Sep, 2020
Review #3 received
Received 21 Aug, 2020
Reviewer #3 agreed
On 22 Jun, 2020
Review #1 received
Received 07 Jun, 2020
Reviewer #2 agreed
On 20 May, 2020
Review #2 received
Received 20 May, 2020
Reviewer #1 agreed
On 18 May, 2020
Reviewers invited
Invitations sent on 16 May, 2020
Editor assigned
On 13 May, 2020
Editor invited
On 12 May, 2020
Submission checks complete
On 30 Apr, 2020
First submitted
On 29 Apr, 2020
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at Systematic Reviews.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Alireza Sedaghat
Mashhad University of Medical Sciences
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Systematic Reviews.
No community comments so far
Editorial decision: Major revision
On 21 Feb, 2021
Editor assigned
On 25 Dec, 2020
Submission checks complete
On 25 Dec, 2020
Editor invited
On 25 Dec, 2020
Version 2
Posted 15 Oct, 2020
No comments provided
Review #1 received
Received 28 Oct, 2020
Review #2 received
Received 19 Oct, 2020
Reviewer #2 agreed
On 15 Oct, 2020
Reviewer #1 agreed
On 14 Oct, 2020
Reviewers invited
Invitations sent on 12 Oct, 2020
Editor assigned
On 07 Oct, 2020
Submission checks complete
On 06 Oct, 2020
Editor invited
On 06 Oct, 2020
No comments provided
Editorial decision: Major revision
On 04 Sep, 2020
Review #3 received
Received 21 Aug, 2020
Reviewer #3 agreed
On 22 Jun, 2020
Review #1 received
Received 07 Jun, 2020
Reviewer #2 agreed
On 20 May, 2020
Review #2 received
Received 20 May, 2020
Reviewer #1 agreed
On 18 May, 2020
Reviewers invited
Invitations sent on 16 May, 2020
Editor assigned
On 13 May, 2020
Editor invited
On 12 May, 2020
Submission checks complete
On 30 Apr, 2020
First submitted
On 29 Apr, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Systematic Reviews.
Purpose: The objective of this systematic review was to evaluate the effect of pre-, pro-, and synbiotics on feeding tolerance of enterally-fed critically ill adult patients.
Methods: Medline, Science Direct, Web of Knowledge, and the Cochrane Central Register of Controlled Trials were searched up to November 2019. English language randomized controlled trials reporting the effect of pre, pro or synbiotics on the feeding tolerance of enterally-fed critically ill adult patients were included.
Results: Overall, 15 papers were selected for review. Among six studies reporting the energy intake, only two studies showed significantly higher energy intake in the prebiotic-receiving groups. Among four RCTs reporting frequency or time to achieve the target calorie, only one found a significant effect of probiotics to reduce the time to achieve a target dose of calorie. About the prevalence or duration of diarrhea, 7 out of 12 RCTs reported a beneficial effect. All but one study found no beneficial effects for gut microbiota manipulation on clinical endpoints including length of stay (LOS) in hospital and intensive care unit (ICU).
Conclusion: It should be noticed that the heterogeneity in study designs, product format, and ICU patient populations makes it difficult to draw any general conclusion. Overall, it seems that pre, pro or synbiotics have not significant beneficial effect on feeding tolerance and clinical endpoints in critically ill adults, but they may reduce the prevalence or duration of diarrhea.
Figure 1
This is a list of supplementary files associated with this preprint. Click to download.
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