This preprint is under consideration at Italian Journal of Pediatrics. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Research Article
Fabio Meneghin
Vittore Buzzi Children's Hospital: Ospedale dei Bambini Vittore Buzzi
Corresponding Author
ORCiD: https://orcid.org/0000-0001-7686-4233
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Neonatal hypoglycemia is a common disorder especially in at-risk infants and it can be associated with poor long-term neurological outcomes. Several therapeutic interventions are suggested, from the implementation of breastfeeding to the glucose intravenous administration. Oral dextrose gel massaged into the infant’s inner cheek is a recent treatment option of asymptomatic hypoglycemia, after which oral feeding is encouraged. This approach seems to reduce the admission of infants to neonatal intensive care unit (NICU) so favouring maternal bonding and breastfeeding success at discharge.
Methods: In our unit we recently implemented the protocol for the management of asymptomatic hypoglycemia with the introduction of dextrose oral gel at 40%. Therefore we compared two cohorts of near term at-risk infants with asymptomatic hypoglycemia: a historical group managed with our old protocol and the second one prospectively followed after the introduction of dextrose gel at 40%.
Results: Primary outcome was occurrence of NICU admission and glucose intravenous needs; breastfeeding success was the secondary outcome. Infants in the dextrose oral gel group showed statistically lower need of NICU admission and higher prevalence of exclusive breastfeeding at discharge compared with infants of the historical group.
Conclusions: In our population the introduction of dextrose oral gel at 40% to the protocol, helped in the safe management of asymptomatic hypoglycemia in near term infants and, at the same time, implemented breastfeeding.
Keywords
hypoglycemia, at-risk newborns, breastfeeding, dextrose gel at 40%, neonatal intensive care unit, NICU admission
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CURRENT STATUS: Under Review
Version (no preprint)
Posted 18 May, 2021
Review #1 received
Received 18 May, 2021
Editorial decision: Major revision
On 18 May, 2021
Reviewer #1 agreed
On 10 May, 2021
Editor assigned
On 09 May, 2021
Reviewers invited
Invitations sent on 09 May, 2021
Submission checks complete
On 09 May, 2021
Editor invited
On 09 May, 2021
This version was not preprinted
Version 1
Posted 01 Mar, 2021
No community comments so far
Editorial decision: Major revision
On 31 Mar, 2021
Review #1 received
Received 25 Mar, 2021
Reviewer #2 agreed
On 14 Mar, 2021
Reviewer #1 agreed
On 12 Mar, 2021
Reviews received
Received 12 Mar, 2021
Reviewers invited
Invitations sent on 24 Feb, 2021
Editor assigned
On 23 Feb, 2021
Submission checks complete
On 23 Feb, 2021
Editor invited
On 23 Feb, 2021
First submitted
On 20 Feb, 2021
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PDF Downloads: ...
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This preprint is under consideration at Italian Journal of Pediatrics. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Fabio Meneghin
Vittore Buzzi Children's Hospital: Ospedale dei Bambini Vittore Buzzi
Corresponding Author
ORCiD: https://orcid.org/0000-0001-7686-4233
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version (no preprint)
Posted 18 May, 2021
Review #1 received
Received 18 May, 2021
Editorial decision: Major revision
On 18 May, 2021
Reviewer #1 agreed
On 10 May, 2021
Editor assigned
On 09 May, 2021
Reviewers invited
Invitations sent on 09 May, 2021
Submission checks complete
On 09 May, 2021
Editor invited
On 09 May, 2021
This version was not preprinted
Version 1
Posted 01 Mar, 2021
No community comments so far
Editorial decision: Major revision
On 31 Mar, 2021
Review #1 received
Received 25 Mar, 2021
Reviewer #2 agreed
On 14 Mar, 2021
Reviewer #1 agreed
On 12 Mar, 2021
Reviews received
Received 12 Mar, 2021
Reviewers invited
Invitations sent on 24 Feb, 2021
Editor assigned
On 23 Feb, 2021
Submission checks complete
On 23 Feb, 2021
Editor invited
On 23 Feb, 2021
First submitted
On 20 Feb, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Neonatal hypoglycemia is a common disorder especially in at-risk infants and it can be associated with poor long-term neurological outcomes. Several therapeutic interventions are suggested, from the implementation of breastfeeding to the glucose intravenous administration. Oral dextrose gel massaged into the infant’s inner cheek is a recent treatment option of asymptomatic hypoglycemia, after which oral feeding is encouraged. This approach seems to reduce the admission of infants to neonatal intensive care unit (NICU) so favouring maternal bonding and breastfeeding success at discharge.
Methods: In our unit we recently implemented the protocol for the management of asymptomatic hypoglycemia with the introduction of dextrose oral gel at 40%. Therefore we compared two cohorts of near term at-risk infants with asymptomatic hypoglycemia: a historical group managed with our old protocol and the second one prospectively followed after the introduction of dextrose gel at 40%.
Results: Primary outcome was occurrence of NICU admission and glucose intravenous needs; breastfeeding success was the secondary outcome. Infants in the dextrose oral gel group showed statistically lower need of NICU admission and higher prevalence of exclusive breastfeeding at discharge compared with infants of the historical group.
Conclusions: In our population the introduction of dextrose oral gel at 40% to the protocol, helped in the safe management of asymptomatic hypoglycemia in near term infants and, at the same time, implemented breastfeeding.
Figure 1
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