This preprint is under consideration at BMC Oral Health. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Research article
Reham AL Jasser
King Saud University
Corresponding Author
ORCiD: https://orcid.org/0000-0002-5783-9697
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Treatment outcomes associated with the peri-implant diseases are significantly influenced by individual habits. Several studies identified smoking as one of the important risk factors associated with ineffective treatment outcomes. The present study aims to compare changes in periodontal clinical parameters between conventional and electronic cigarette smokers with non-smokers. It further evaluates changes of salivary inflammatory biomarkers (IL-1 β, IL-6, MMP-8 and TIMP1) after treating peri-implantitis. Participants were divided into three groups: conventional cigarette smokers, E-smokers and non-smokers; each consisting of 20 participants.
Results: Findings of the study indicated that the change in gingival color from red to pink is significantly higher in cigarette smokers and non-smokers when compared with electronic smokers (p=0.043). The gingival consistent changed to be firm in cigarettes smokers and non-smokers. The prevalence of PI, BOP and PD it has reduced across the groups of cigarette and smokers over the four intervals of observation. Besides, no statistically significant difference with the means values of KTW. The level of MMP-8 at baseline of three groups had reduced but increased marginally at sixth month and at the completion of one year among cigarette and e-smokers. The mean IL-6 values had significantly reduced, except for electronic smoking. The IL-1 β values had significantly increased in all groups. The increase of TIMP-1 values in non-smokers is higher at all the three-time points.
Conclusion: All clinical parameters show enhancement post treatment. However, salivary biological biomarkers (MMP-8, IL-1 β and IL-6) have shown a decline in all groups treated.
Keywords
Smoking, Peri-Implant Disease, Risk factor, Peri-implantitis therapy
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CURRENT STATUS: Under Review
Version 1
Posted 01 Mar, 2021
No community comments so far
Reviewer #1 agreed
On 22 May, 2021
Reviewers invited
Invitations sent on 08 Apr, 2021
Editor assigned
On 02 Mar, 2021
Submission checks complete
On 22 Feb, 2021
Editor invited
On 16 Feb, 2021
First submitted
On 08 Feb, 2021
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Subject Areas
Dentistry
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This preprint is under consideration at BMC Oral Health. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Reham AL Jasser
King Saud University
Corresponding Author
ORCiD: https://orcid.org/0000-0002-5783-9697
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 01 Mar, 2021
No community comments so far
Reviewer #1 agreed
On 22 May, 2021
Reviewers invited
Invitations sent on 08 Apr, 2021
Editor assigned
On 02 Mar, 2021
Submission checks complete
On 22 Feb, 2021
Editor invited
On 16 Feb, 2021
First submitted
On 08 Feb, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Dentistry
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Treatment outcomes associated with the peri-implant diseases are significantly influenced by individual habits. Several studies identified smoking as one of the important risk factors associated with ineffective treatment outcomes. The present study aims to compare changes in periodontal clinical parameters between conventional and electronic cigarette smokers with non-smokers. It further evaluates changes of salivary inflammatory biomarkers (IL-1 β, IL-6, MMP-8 and TIMP1) after treating peri-implantitis. Participants were divided into three groups: conventional cigarette smokers, E-smokers and non-smokers; each consisting of 20 participants.
Results: Findings of the study indicated that the change in gingival color from red to pink is significantly higher in cigarette smokers and non-smokers when compared with electronic smokers (p=0.043). The gingival consistent changed to be firm in cigarettes smokers and non-smokers. The prevalence of PI, BOP and PD it has reduced across the groups of cigarette and smokers over the four intervals of observation. Besides, no statistically significant difference with the means values of KTW. The level of MMP-8 at baseline of three groups had reduced but increased marginally at sixth month and at the completion of one year among cigarette and e-smokers. The mean IL-6 values had significantly reduced, except for electronic smoking. The IL-1 β values had significantly increased in all groups. The increase of TIMP-1 values in non-smokers is higher at all the three-time points.
Conclusion: All clinical parameters show enhancement post treatment. However, salivary biological biomarkers (MMP-8, IL-1 β and IL-6) have shown a decline in all groups treated.
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