1 Fraga, A. M., Souza de Araujo, E. S., Stabellini, R., Vergani, N. & Pereira, L. V. A survey of parameters involved in the establishment of new lines of human embryonic stem cells. Stem Cell Rev Rep7, 775-781, doi:10.1007/s12015-011-9250-x (2011).
2 Fernandez-Alonso, R., Bustos, F., Williams, C. A. C. & Findlay, G. M. Protein Kinases in Pluripotency-Beyond the Usual Suspects. J Mol Biol429, 1504-1520, doi:10.1016/j.jmb.2017.04.013 (2017).
3 Fernandes, A. M. et al. Worldwide survey of published procedures to culture human embryonic stem cells. Cell Transplant19, 509-523, doi:10.3727/096368909X485067 (2010).
4 Fedorcsak, P. & Storeng, R. Effects of leptin and leukemia inhibitory factor on preimplantation development and STAT3 signaling of mouse embryos in vitro. Biol.Reprod.69, 1531-1538 (2003).
5 Kauma, S. W. & Matt, D. W. Coculture cells that express leukemia inhibitory factor (LIF) enhance mouse blastocyst development in vitro. J Assist Reprod Genet12, 153-156, doi:10.1007/bf02211386 (1995).
6 Mitchell, M. H., Swanson, R. J., Hodgen, G. D. & Oehninger, S. Enhancement of in vitro murine embryo development by recombinant leukemia inhibitory factor. J Soc Gynecol Investig1, 215-219, doi:10.1177/107155769400100307 (1994).
7 Nicola, N. A. & Babon, J. J. Leukemia inhibitory factor (LIF). Cytokine Growth Factor Rev26, 533-544, doi:10.1016/j.cytogfr.2015.07.001 (2015).
8 Morgani, S. M. & Brickman, J. M. LIF supports primitive endoderm expansion during pre-implantation development. Development142, 3488-3499, doi:10.1242/dev.125021 (2015).
9 Fukui, Y. & Matsuyama, K. Development of in vitro matured and fertilized bovine embryos cultured in media containing human leukemia inhibitory factor. Theriogenology42, 663-673, doi:10.1016/0093-691x(94)90383-t (1994).
10 Sirisathien, S. et al. Effect of leukemia inhibitory factor on bovine embryos produced in vitro under chemically defined conditions. Theriogenology59, 1751-1763, doi:10.1016/s0093-691x(02)01258-x (2003).
11 Vejlsted, M., Avery, B., Gjorret, J. O. & Maddox-Hyttel, P. Effect of leukemia inhibitory factor (LIF) on in vitro produced bovine embryos and their outgrowth colonies. Mol Reprod Dev70, 445-454, doi:10.1002/mrd.20221 (2005).
12 Yamanaka, K., Kudo, T., Kimura, N., Amano, T. & Itagaki, Y. Effect of bovine leukemia inhibitory factor on hatching and numbers of inner cell mass and trophectoderm of bovine intact and biopsied blastocysts. Anim Sci J70, 444-450 (1999).
13 Kocyigit, A. & Cevik, M. Effects of leukemia inhibitory factor and insulin-like growth factor-I on the cell allocation and cryotolerance of bovine blastocysts. Cryobiology71, 64-69, doi:10.1016/j.cryobiol.2015.05.068 (2015).
14 Kocyigit, A. & Cevik, M. Leucemia inhibitory factor; investigating the time-dependent effect on viability of vitrified bovine embryos. Reprod Domest Anim52, 1113-1119, doi:10.1111/rda.13040 (2017).
15 Rodriguez, A. et al. Effects of human versus mouse leukemia inhibitory factor on the in vitro development of bovine embryos. Theriogenology67, 1092-1095, doi:10.1016/j.theriogenology.2006.11.015 (2007).
16 Wooldridge, L. K. & Ealy, A. D. Interleukin-6 promotes primitive endoderm development in bovine blastocysts BMC Developmental BiologySubmitted (2020).
17 Wooldridge, L. K. & Ealy, A. D. Interleukin-6 increases inner cell mass numbers in bovine embryos. BMC Dev Biol19, 2, doi:10.1186/s12861-019-0182-z (2019).
18 Wooldridge, L. K., Johnson, S. E., Cockrum, R. R. & Ealy, A. D. Interleukin-6 requires JAK to stimulate inner cell mass expansion in bovine embryos. Reproduction, doi:10.1530/REP-19-0286 (2019).
19 Knijn, H. M. et al. Consequences of in vivo development and subsequent culture on apoptosis, cell number, and blastocyst formation in bovine embryos. Biol Reprod69, 1371-1378, doi:10.1095/biolreprod.103.017251 (2003).
20 Iwasaki, S., Yoshiba, N., Ushijima, H., Watanabe, S. & Nakahara, T. Morphology and proportion of inner cell mass of bovine blastocysts fertilized in vitro and in vivo. J Reprod Fertil90, 279-284, doi:10.1530/jrf.0.0900279 (1990).
21 Fischer-Brown, A. E. et al. Embryonic disc development and subsequent viability of cattle embryos following culture in two media under two oxygen concentrations. Reprod Fertil Dev16, 787-793, doi:RD04026 [pii] (2004).
22 Bertolini, M. et al. Growth, development, and gene expression by in vivo- and in vitro-produced day 7 and 16 bovine embryos. Mol Reprod Dev63, 318-328, doi:10.1002/mrd.90015 (2002).
23 Alberto, M. L. et al. Development of bovine embryos derived from reproductive techniques. Reprod Fertil Dev25, 907-917, doi:10.1071/RD12092 (2013).
24 Mess, A. M. et al. Vascularization and VEGF expression altered in bovine yolk sacs from IVF and NT technologies. Theriogenology87, 290-297, doi:10.1016/j.theriogenology.2016.09.012 (2017).
25 Rose-John, S. Interleukin-6 Family Cytokines. Cold Spring Harb Perspect Biol10, doi:10.1101/cshperspect.a028415 (2018).
26 Johnson, D. E., O'Keefe, R. A. & Grandis, J. R. Targeting the IL-6/JAK/STAT3 signalling axis in cancer. Nat Rev Clin Oncol15, 234-248, doi:10.1038/nrclinonc.2018.8 (2018).
27 Meng, F., Forrester-Gauntlett, B., Turner, P., Henderson, H. & Oback, B. Signal Inhibition Reveals JAK/STAT3 Pathway as Critical for Bovine Inner Cell Mass Development. Biol Reprod93, 132, doi:10.1095/biolreprod.115.134254 (2015).
28 Wooldridge, L. K. & Ealy, A. D. Interleukin-6 promotes primitive endoderm development in bovine blastocysts. BMC Dev Biol21, 3, doi:10.1186/s12861-020-00235-z (2021).
29 Ramos-Ibeas, P. et al. Embryonic disc formation following post-hatching bovine embryo development in vitro. Reproduction160, 579-589, doi:10.1530/REP-20-0243 (2020).
30 Isaac, E. & Pfeffer, P. L. Growing cattle embryos beyond Day 8 - An investigation of media components. Theriogenology161, 273-284, doi:10.1016/j.theriogenology.2020.12.010 (2021).
31 Kuijk, E. W. et al. The roles of FGF and MAP kinase signaling in the segregation of the epiblast and hypoblast cell lineages in bovine and human embryos. Development139, 871-882, doi:10.1242/dev.071688 (2012).
32 Yang, Q. E. et al. Fibroblast growth factor 2 promotes primitive endoderm development in bovine blastocyst outgrowths. Biol Reprod85, 946-953, doi:10.1095/biolreprod.111.093203 (2011).
33 Yamanaka, Y., Lanner, F. & Rossant, J. FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst. Development137, 715-724, doi:137/5/715 [pii]10.1242/dev.043471 (2010).
34 Hosoe, M. et al. Characterisation of bovine embryos following prolonged culture in embryonic stem cell medium containing leukaemia inhibitory factor. Reprod Fertil Dev31, 1157-1165, doi:10.1071/RD18343 (2019).
35 Yoshida, K. et al. Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc Natl Acad Sci U S A93, 407-411 (1996).
36 Ware, C. B. et al. Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death. Development121, 1283-1299 (1995).
37 McFarland-Mancini, M. M. et al. Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor. J Immunol184, 7219-7228, doi:10.4049/jimmunol.0901929 (2010).
38 Reese, S. T. et al. Pregnancy loss in beef cattle: A meta-analysis. Anim Reprod Sci212, 106251, doi:10.1016/j.anireprosci.2019.106251 (2020).
39 Ealy, A. D., Wooldridge, L. K. & McCoski, S. R. Post-transfer Consequences of In Vitro-Produced Embryos in Cattle. J Anim Sci, doi:10.1093/jas/skz116 (2019).
40 Wiltbank, M. C. et al. Pivotal periods for pregnancy loss during the first trimester of gestation in lactating dairy cows. Theriogenology86, 239-253, doi:10.1016/j.theriogenology.2016.04.037 (2016).
41 Zhang, K., Hansen, P. J. & Ealy, A. D. Fibroblast growth factor 10 enhances bovine oocyte maturation and developmental competence in vitro. Reproduction140, 815-826, doi:REP-10-0190 [pii]10.1530/REP-10-0190 (2010).