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Association between five types of Tumor Necrosis Factor-α Gene Polymorphism and Hepatocellular Carcinoma Risk: A Meta-Analysis
Citrawati Dyah Kencono Wungu
Universitas Airlangga Fakultas Kedokteran
Corresponding Author
ORCiD: https://orcid.org/0000-0001-5180-957X
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View the published version at BMC Cancer.
Background: Research focusing on the relationship between five types of tumor necrosis factor-alpha (TNF-α) SNPs and the risk of hepatocellular carcinoma (HCC) were still controversial. Hereby, we performed a meta-analysis to determine the association between TNF-α promoter SNPs: -1031 T/C, -863 C/A, -857 C/T, -308 G/A, and -238 G/A with HCC risk.
Methods: We interrogated articles from journal database: PubMed, Pro-Quest, EBSCO, Science Direct, and Springer to determine the relationship between five types of SNPs in TNF-α gene with HCC risk. RevMan 5.3 software was used for analysis in fixed/random effect models.
Results: This meta-analysis included 23 potential articles from 2004-2018 with 3,237 HCC cases and 4,843 controls. We found that SNP -863 C/A were associated with a significantly increased HCC risk (A vs C, OR=1.31, 95% CI=1.03-1.67). Similar results were obtained in -857 C/T (TT/CT vs CC, OR=1.31, 95% CI=1.06-1.62), -308 G/A (AA vs GG, OR=3.14, 95% CI=2.06-4.79), and -238 G/A (AA vs GG, OR=3.87, 95% CI=1.32-11.34). While no associations were observed between SNP TNF-α -1031 T/C and HCC risk.
Conclusions: The present meta-analysis showed that TNFα SNPs -863C/A, -857 C/T, -308 G/A, and -238 G/A were associated with the risk of HCC.
Keywords
Meta-analysis, tumor necrosis factor-α, single nucleotide polymorphism, hepatocellular carcinoma
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CURRENT STATUS: Published
Version 2
Posted 28 Sep, 2020
Published
On 23 Nov, 2020
Published
On 23 Nov, 2020
No community comments so far
Editorial decision: Accept
On 30 Oct, 2020
Review #1 received
Received 19 Oct, 2020
Reviewer #1 agreed
On 27 Sep, 2020
Reviewers invited
Invitations sent on 27 Sep, 2020
Editor assigned
On 22 Sep, 2020
Submission checks complete
On 21 Sep, 2020
Editor invited
On 21 Sep, 2020
No comments provided
Editorial decision: Major revision
On 01 Aug, 2020
Reviewer #4 agreed
On 22 Jul, 2020
Review #3 received
Received 30 Jun, 2020
Review #1 received
Received 22 Jun, 2020
Reviewer #2 agreed
On 11 Jun, 2020
Reviewer #3 agreed
On 11 Jun, 2020
Review #2 received
Received 11 Jun, 2020
Reviewer #1 agreed
On 31 May, 2020
Reviewers invited
Invitations sent on 29 May, 2020
Editor assigned
On 27 May, 2020
Submission checks complete
On 20 May, 2020
Editor invited
On 18 May, 2020
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This preprint is under consideration at BMC Cancer. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Association between five types of Tumor Necrosis Factor-α Gene Polymorphism and Hepatocellular Carcinoma Risk: A Meta-Analysis
Citrawati Dyah Kencono Wungu
Universitas Airlangga Fakultas Kedokteran
Corresponding Author
ORCiD: https://orcid.org/0000-0001-5180-957X
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 2
Posted 28 Sep, 2020
Published
On 23 Nov, 2020
Published
On 23 Nov, 2020
No community comments so far
Editorial decision: Accept
On 30 Oct, 2020
Review #1 received
Received 19 Oct, 2020
Reviewer #1 agreed
On 27 Sep, 2020
Reviewers invited
Invitations sent on 27 Sep, 2020
Editor assigned
On 22 Sep, 2020
Submission checks complete
On 21 Sep, 2020
Editor invited
On 21 Sep, 2020
No comments provided
Editorial decision: Major revision
On 01 Aug, 2020
Reviewer #4 agreed
On 22 Jul, 2020
Review #3 received
Received 30 Jun, 2020
Review #1 received
Received 22 Jun, 2020
Reviewer #2 agreed
On 11 Jun, 2020
Reviewer #3 agreed
On 11 Jun, 2020
Review #2 received
Received 11 Jun, 2020
Reviewer #1 agreed
On 31 May, 2020
Reviewers invited
Invitations sent on 29 May, 2020
Editor assigned
On 27 May, 2020
Submission checks complete
On 20 May, 2020
Editor invited
On 18 May, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Cancer.
Background: Research focusing on the relationship between five types of tumor necrosis factor-alpha (TNF-α) SNPs and the risk of hepatocellular carcinoma (HCC) were still controversial. Hereby, we performed a meta-analysis to determine the association between TNF-α promoter SNPs: -1031 T/C, -863 C/A, -857 C/T, -308 G/A, and -238 G/A with HCC risk.
Methods: We interrogated articles from journal database: PubMed, Pro-Quest, EBSCO, Science Direct, and Springer to determine the relationship between five types of SNPs in TNF-α gene with HCC risk. RevMan 5.3 software was used for analysis in fixed/random effect models.
Results: This meta-analysis included 23 potential articles from 2004-2018 with 3,237 HCC cases and 4,843 controls. We found that SNP -863 C/A were associated with a significantly increased HCC risk (A vs C, OR=1.31, 95% CI=1.03-1.67). Similar results were obtained in -857 C/T (TT/CT vs CC, OR=1.31, 95% CI=1.06-1.62), -308 G/A (AA vs GG, OR=3.14, 95% CI=2.06-4.79), and -238 G/A (AA vs GG, OR=3.87, 95% CI=1.32-11.34). While no associations were observed between SNP TNF-α -1031 T/C and HCC risk.
Conclusions: The present meta-analysis showed that TNFα SNPs -863C/A, -857 C/T, -308 G/A, and -238 G/A were associated with the risk of HCC.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5