Association between five types of Tumor Necrosis Factor-α Gene Polymorphism and Hepatocellular Carcinoma Risk: A Meta-Analysis
Background: Research focusing on the relationship between five types of tumor necrosis factor-alpha (TNF-α) SNPs and the risk of hepatocellular carcinoma (HCC) were still controversial. Hereby, we performed a meta-analysis to determine the association between TNF-α promoter SNPs: -1031 T/C, -863 C/A, -857 C/T, -308 G/A, and -238 G/A with HCC risk.
Methods: We interrogated articles from journal database: PubMed, Pro-Quest, EBSCO, Science Direct, and Springer to determine the relationship between five types of SNPs in TNF-α gene with HCC risk. RevMan 5.3 software was used for analysis in fixed/random effect models.
Results: This meta-analysis included 23 potential articles from 2004-2018 with 3,237 HCC cases and 4,843 controls. We found that SNP -863 C/A were associated with a significantly increased HCC risk (A vs C, OR=1.31, 95% CI=1.03-1.67). Similar results were obtained in -857 C/T (TT/CT vs CC, OR=1.31, 95% CI=1.06-1.62), -308 G/A (AA vs GG, OR=3.14, 95% CI=2.06-4.79), and -238 G/A (AA vs GG, OR=3.87, 95% CI=1.32-11.34). While no associations were observed between SNP TNF-α -1031 T/C and HCC risk.
Conclusions: The present meta-analysis showed that TNFα SNPs -863C/A, -857 C/T, -308 G/A, and -238 G/A were associated with the risk of HCC.
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Posted 28 Sep, 2020
On 23 Nov, 2020
On 23 Nov, 2020
On 30 Oct, 2020
Received 19 Oct, 2020
On 27 Sep, 2020
Invitations sent on 27 Sep, 2020
On 22 Sep, 2020
On 21 Sep, 2020
On 21 Sep, 2020
On 01 Aug, 2020
On 22 Jul, 2020
Received 30 Jun, 2020
Received 22 Jun, 2020
On 11 Jun, 2020
On 11 Jun, 2020
Received 11 Jun, 2020
On 31 May, 2020
Invitations sent on 29 May, 2020
On 27 May, 2020
On 20 May, 2020
On 18 May, 2020
Association between five types of Tumor Necrosis Factor-α Gene Polymorphism and Hepatocellular Carcinoma Risk: A Meta-Analysis
Posted 28 Sep, 2020
On 23 Nov, 2020
On 23 Nov, 2020
On 30 Oct, 2020
Received 19 Oct, 2020
On 27 Sep, 2020
Invitations sent on 27 Sep, 2020
On 22 Sep, 2020
On 21 Sep, 2020
On 21 Sep, 2020
On 01 Aug, 2020
On 22 Jul, 2020
Received 30 Jun, 2020
Received 22 Jun, 2020
On 11 Jun, 2020
On 11 Jun, 2020
Received 11 Jun, 2020
On 31 May, 2020
Invitations sent on 29 May, 2020
On 27 May, 2020
On 20 May, 2020
On 18 May, 2020
Background: Research focusing on the relationship between five types of tumor necrosis factor-alpha (TNF-α) SNPs and the risk of hepatocellular carcinoma (HCC) were still controversial. Hereby, we performed a meta-analysis to determine the association between TNF-α promoter SNPs: -1031 T/C, -863 C/A, -857 C/T, -308 G/A, and -238 G/A with HCC risk.
Methods: We interrogated articles from journal database: PubMed, Pro-Quest, EBSCO, Science Direct, and Springer to determine the relationship between five types of SNPs in TNF-α gene with HCC risk. RevMan 5.3 software was used for analysis in fixed/random effect models.
Results: This meta-analysis included 23 potential articles from 2004-2018 with 3,237 HCC cases and 4,843 controls. We found that SNP -863 C/A were associated with a significantly increased HCC risk (A vs C, OR=1.31, 95% CI=1.03-1.67). Similar results were obtained in -857 C/T (TT/CT vs CC, OR=1.31, 95% CI=1.06-1.62), -308 G/A (AA vs GG, OR=3.14, 95% CI=2.06-4.79), and -238 G/A (AA vs GG, OR=3.87, 95% CI=1.32-11.34). While no associations were observed between SNP TNF-α -1031 T/C and HCC risk.
Conclusions: The present meta-analysis showed that TNFα SNPs -863C/A, -857 C/T, -308 G/A, and -238 G/A were associated with the risk of HCC.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5