This preprint is under consideration at Breast Cancer Research and Treatment. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Tomi Akinyemiju
Duke University School of Medicine
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1412-3234
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose: There is conflicting evidence on the role of lipid biomarkers in breast cancer (BC), and no study to our knowledge has examined this association among African women.
Methods: We estimated odds ratios (ORs) and 95% confidence intervals (95% CI) for the association of lipid biomarkers – total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides – with odds of BC overall and by subtype (Luminal A, Luminal B, HER2-enriched and triple-negative or TNBC) for 296 newly diagnosed BC cases and 116 healthy controls in Nigeria.
Results: Cases were slightly older than controls (48.5 vs. 46.0) and had a lower BMI (25.4 vs. 26.5). Each unit SD increase in triglycerides was associated with 39% increased odds of BC in fully adjusted models (aOR: 1.39; 95% CI: 1.03, 1.86). However, there were no significant associations of total cholesterol, LDL and HDL with odds of breast cancer in fully adjusted models. In analysis of molecular subtypes, each unit SD increase in LDL was associated with 64% increased odds of Luminal B BC (aOR 1.64; 95% CI: 1.06, 2.55). Each unit SD decrease in HDL was associated with 49% increased odds of TNBC (aOR: 1.49, 95% CI: 0.94, 2.34), and clinically low HDL was associated with 2.7 times increased odds of TNBC (aOR 2.67; 95% CI: 1.10, 6.49).
Conclusions: Low HDL and high LDL appear to significantly increase the odds of TN and Luminal B BC, among African women. Future prospective studies can characterize this association and inform clinical approaches targeting HDL as a BC prevention strategy.
Keywords
cholesterol, breast cancer, Nigeria, molecular subtype, lipid
Figure 1
Figure 2
Figure 3
Loading...
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 09 Mar, 2021
No community comments so far
Review #? received
Received 06 Mar, 2021
Reviewers invited
Invitations sent on 01 Mar, 2021
Editor invited
On 01 Mar, 2021
Editor assigned
On 23 Feb, 2021
First submitted
On 23 Feb, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Learn more about our company.
This preprint is under consideration at Breast Cancer Research and Treatment. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Tomi Akinyemiju
Duke University School of Medicine
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1412-3234
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 09 Mar, 2021
No community comments so far
Review #? received
Received 06 Mar, 2021
Reviewers invited
Invitations sent on 01 Mar, 2021
Editor invited
On 01 Mar, 2021
Editor assigned
On 23 Feb, 2021
First submitted
On 23 Feb, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose: There is conflicting evidence on the role of lipid biomarkers in breast cancer (BC), and no study to our knowledge has examined this association among African women.
Methods: We estimated odds ratios (ORs) and 95% confidence intervals (95% CI) for the association of lipid biomarkers – total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides – with odds of BC overall and by subtype (Luminal A, Luminal B, HER2-enriched and triple-negative or TNBC) for 296 newly diagnosed BC cases and 116 healthy controls in Nigeria.
Results: Cases were slightly older than controls (48.5 vs. 46.0) and had a lower BMI (25.4 vs. 26.5). Each unit SD increase in triglycerides was associated with 39% increased odds of BC in fully adjusted models (aOR: 1.39; 95% CI: 1.03, 1.86). However, there were no significant associations of total cholesterol, LDL and HDL with odds of breast cancer in fully adjusted models. In analysis of molecular subtypes, each unit SD increase in LDL was associated with 64% increased odds of Luminal B BC (aOR 1.64; 95% CI: 1.06, 2.55). Each unit SD decrease in HDL was associated with 49% increased odds of TNBC (aOR: 1.49, 95% CI: 0.94, 2.34), and clinically low HDL was associated with 2.7 times increased odds of TNBC (aOR 2.67; 95% CI: 1.10, 6.49).
Conclusions: Low HDL and high LDL appear to significantly increase the odds of TN and Luminal B BC, among African women. Future prospective studies can characterize this association and inform clinical approaches targeting HDL as a BC prevention strategy.
Figure 1
Figure 2
Figure 3
Loading...