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Research article
A Clinical Study on Hyperbaric Oxygen Therapy to Treat Severe Traumatic Brain Injury Traumatic Brain Injury
lin zhu
3201 hospital affiliated of xi'an JiaoTong University
Corresponding Author
ORCiD: https://orcid.org/0000-0002-6331-9444
License:
This work is licensed under a CC BY 4.0 License. Read Full License
This clinical research initiates to study the early hyperbaric oxygen therapy applied in Severe Traumatic Brain Injury based on lots of clinical treatment practice for the Severe Craniocerebral Injury patients, whose survival and rehabilitation has drawn great attention among neurosurgeon experts.
Background: 1. To investigate the clinical effect of early stage hyperbaric oxygen therapy in the treatment of severe traumatic brain injury; 2. To study the treatment therapy of when to apply hyperbaric oxygen therapy to Severe Craniocerebral Injury patients; 3. To study if combining removal of intracerebral hematoma and craniotomy decompression with early stage hyperbaric oxygen therapy can achieve more effective treatment results.
Methodology: 90 cases of severe craniocerebral injury patients admitted to neurosurgery department of 3201 hospital affiliated of Xi’an Jiaotong university were randomly divided into observation group and control group from January 2016 to January 2017, craniotomy for decompression and removal of intracerebral hematoma were performed in both groups. Hyperbaric oxygen therapy was started in the early postoperative period in the observation group and in the late postoperative period in the control group. The Glasgow Coma Scale Score (GCS) of the two groups were compared before and after operation. Patients were followed up for 6 months, the clinical prognosis was assessed by the Glasgow Outcome Scale Score (GOS) and long-term Karnofsky Performance Status Score (KPS).
Results: After treatment, GCS (Glasgow Coma Scale Score) scores of observation group was significantly higher than that of control group (P<O.05); After 6 months’ follow-up, the GOS (Glasgow Outcome Scale score) scores of observation group was significantly higher than that of control group (P<0.05), the favorable prognosis rate was significantly higher than that of the control group (P<0.05). The KPS (Karnofsky Performance Status Score) scores of the observation group were significantly better than that of the control group, and the difference was statistically significant (P < 0.05).
Conclusion: Combing craniotomy decompression and removal of intracerebral hematoma with early hyperbaric oxygen-assisted therapy can significantly improve the survival rate, recovery rate and clinical prognosis of patients with severe traumatic brain injury.
Keywords
Severe traumatic brain injury, Standard large traumatic craniotomy, Early Hyperbaric oxygen Therapy
George Visger
commented on 16 May, 2020
I developed hydrocephalus from concussions while playing with the SF 49ers in 1981 at age 23. I underwent 3 emergency VP shunt brain surgeries in 10 months, comatose after the 2nd. In the next 12 years I underwent a total of 9 emergency shunt revisions and several grand mal seizures. In 2010, nearly 30 years post 1st brain surgery I began HBOT after undergoing a 3 day Neuro cognitive evaluation. After every 40 treatments I underwent a 6 hr Neuro cognitive evaluation and after my 160th HBOT my Neuro cognitive memory scores improved 14.3%, AND I quit all 4 dementia meds I was on. I’ve now completed 238 HBOT and at age 61 still functioning.
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CURRENT STATUS: Under Review
Version 1
Posted 11 May, 2020
Community comments: 1
Editorial decision: Major revision
On 24 Feb, 2021
Review #2 received
Received 21 Feb, 2021
Review #1 received
Received 15 Oct, 2020
Reviewer #2 agreed
On 16 Sep, 2020
Reviewer #1 agreed
On 09 Sep, 2020
Reviewers invited
Invitations sent on 24 Jul, 2020
Submission checks complete
On 06 May, 2020
Editor assigned
On 28 Apr, 2020
Editor invited
On 27 Apr, 2020
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This preprint is under consideration at BMC Neuroscience. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
A Clinical Study on Hyperbaric Oxygen Therapy to Treat Severe Traumatic Brain Injury Traumatic Brain Injury
lin zhu
3201 hospital affiliated of xi'an JiaoTong University
Corresponding Author
ORCiD: https://orcid.org/0000-0002-6331-9444
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 11 May, 2020
Community comments: 1
Editorial decision: Major revision
On 24 Feb, 2021
Review #2 received
Received 21 Feb, 2021
Review #1 received
Received 15 Oct, 2020
Reviewer #2 agreed
On 16 Sep, 2020
Reviewer #1 agreed
On 09 Sep, 2020
Reviewers invited
Invitations sent on 24 Jul, 2020
Submission checks complete
On 06 May, 2020
Editor assigned
On 28 Apr, 2020
Editor invited
On 27 Apr, 2020
Metrics
Comments: 1
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
This clinical research initiates to study the early hyperbaric oxygen therapy applied in Severe Traumatic Brain Injury based on lots of clinical treatment practice for the Severe Craniocerebral Injury patients, whose survival and rehabilitation has drawn great attention among neurosurgeon experts.
Background: 1. To investigate the clinical effect of early stage hyperbaric oxygen therapy in the treatment of severe traumatic brain injury; 2. To study the treatment therapy of when to apply hyperbaric oxygen therapy to Severe Craniocerebral Injury patients; 3. To study if combining removal of intracerebral hematoma and craniotomy decompression with early stage hyperbaric oxygen therapy can achieve more effective treatment results.
Methodology: 90 cases of severe craniocerebral injury patients admitted to neurosurgery department of 3201 hospital affiliated of Xi’an Jiaotong university were randomly divided into observation group and control group from January 2016 to January 2017, craniotomy for decompression and removal of intracerebral hematoma were performed in both groups. Hyperbaric oxygen therapy was started in the early postoperative period in the observation group and in the late postoperative period in the control group. The Glasgow Coma Scale Score (GCS) of the two groups were compared before and after operation. Patients were followed up for 6 months, the clinical prognosis was assessed by the Glasgow Outcome Scale Score (GOS) and long-term Karnofsky Performance Status Score (KPS).
Results: After treatment, GCS (Glasgow Coma Scale Score) scores of observation group was significantly higher than that of control group (P<O.05); After 6 months’ follow-up, the GOS (Glasgow Outcome Scale score) scores of observation group was significantly higher than that of control group (P<0.05), the favorable prognosis rate was significantly higher than that of the control group (P<0.05). The KPS (Karnofsky Performance Status Score) scores of the observation group were significantly better than that of the control group, and the difference was statistically significant (P < 0.05).
Conclusion: Combing craniotomy decompression and removal of intracerebral hematoma with early hyperbaric oxygen-assisted therapy can significantly improve the survival rate, recovery rate and clinical prognosis of patients with severe traumatic brain injury.
George Visger
commented on 16 May, 2020
I developed hydrocephalus from concussions while playing with the SF 49ers in 1981 at age 23. I underwent 3 emergency VP shunt brain surgeries in 10 months, comatose after the 2nd. In the next 12 years I underwent a total of 9 emergency shunt revisions and several grand mal seizures. In 2010, nearly 30 years post 1st brain surgery I began HBOT after undergoing a 3 day Neuro cognitive evaluation. After every 40 treatments I underwent a 6 hr Neuro cognitive evaluation and after my 160th HBOT my Neuro cognitive memory scores improved 14.3%, AND I quit all 4 dementia meds I was on. I’ve now completed 238 HBOT and at age 61 still functioning.