Ti-4822 TiAl alloy is a typical intermetallic compound with great potential applications in aeronautics and astronautics, such as high-pressure compressors and low-pressure turbine blades of aero-engines. The laser directed energy deposition (DED) and grinding technologies are the effective methods for forming and finish machining the Ti-4822 parts with geometries. However, the DED Ti-4822 is a typical hard-brittle and difficult machining material with poor thermal conductivity and rough surface, leading to a poor grinding surface integrity. Therefore, in order to investigate the grinding performance of DED Ti-4822, a new prediction model of grinding force was proposed with combination of single grain grinding and dynamic active grains grinding simulation in this paper. The influence of grinding parameters and grinding wheels on grinding force, grinding force ratio, surface morphology of specimens, grinding wheels and debris, and microhardness of DED Ti-4822 and similar superalloys was analyzed by the single-factor and orthogonal experiments. The experimental results demonstrated that low feed speed, small grinding depth and high grinding speed are beneficial to reduce grinding force and surface roughness (0.19-0.51). Compared with CBN wheel, the diamond wheel is more appropriate for processing DED Ti-4822 because of smoother grinding surface with less defects and lower wheel wear. In terms of microhardness, significant surface hardening will be generated by grinding DED Ti-4822. The maximum hardness can reach 776.6 HV and the mean depth of grinding hardened layer is about 20μm.