See the published version of this preprint at BMC Pregnancy and Childbirth.
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Research article
Geum Joon Cho
Korea University College of Medicine
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Our objective was to evaluate risks of adverse obstetric outcomes in pregnancies with myoma(s) or in pregnancies following myomectomy.
Methods: We analyzed the national health insurance database, which covers almost the entire Korean population, between 2004 and 2015. The risks of adverse pregnancy outcomes in pregnancies with myoma(s) or in pregnancies following myomectomy, compared to those in women without a diagnosed myoma, were analyzed in multivariate logistic regression analysis.
Results: During the study period, 38,402 women with diagnosed myoma(s), 9,890 women with a history of myomectomy, and 740,675 women without a diagnosed myoma gave birth. Women with a history of diagnosed myoma(s) and women with a history of myomectomy had significantly higher risks of cesarean section (aOR 1.13, 95% CI 1.1-1.16 and aOR 7.46, 95% CI 6.97-7.98, respectively) and placenta previa (aOR 1.41, 95% CI 1.29-1.54 and aOR 1.58, 95% CI 1.35-1.83, respectively), compared to women without a diagnosed myoma. And the risk of uterine rupture was significantly higher in women with previous myomectomy (aOR 12.78, 95% CI 6.5-25.13), compared to women without a diagnosed myoma, which was much increased (aOR 41.35, 95% CI 16.18-105.69) in nulliparous women. The incidence of uterine rupture was the highest at delivery within one year after myomectomy and decreased over time after myomectomy.
Conclusions: Women with a history of myomectomy had significantly higher risks of cesarean section and placenta previa compared to women without a diagnosed myoma.
Keywords
Myoma, Myomectomy, Pregnancy outcome, Uterine rupture
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Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Pregnancy and Childbirth.
Community comments: 1
Editorial decision: Accept
On 08 Nov, 2020
Editor assigned
On 07 Nov, 2020
Submission checks complete
On 07 Nov, 2020
Editor invited
On 07 Nov, 2020
Version 3
Posted 16 Sep, 2020
No comments provided
Editorial decision: Minor revision
On 08 Oct, 2020
Review #2 received
Received 26 Sep, 2020
Reviewer #2 agreed
On 24 Sep, 2020
Reviewers invited
Invitations sent on 23 Sep, 2020
Reviewer #1 agreed
On 23 Sep, 2020
Review #1 received
Received 23 Sep, 2020
Editor assigned
On 15 Sep, 2020
Submission checks complete
On 14 Sep, 2020
Editor invited
On 14 Sep, 2020
No comments provided
Editorial decision: Major revision
On 17 Aug, 2020
Review #2 received
Received 12 Aug, 2020
Reviewer #2 agreed
On 11 Aug, 2020
Editor assigned
On 09 Aug, 2020
Reviewers invited
Invitations sent on 09 Aug, 2020
Reviewer #1 agreed
On 09 Aug, 2020
Review #1 received
Received 09 Aug, 2020
Submission checks complete
On 08 Aug, 2020
Editor invited
On 08 Aug, 2020
No comments provided
Editorial decision: Major revision
On 06 Jul, 2020
Reviewer #3 agreed
On 07 Jun, 2020
Review #3 received
Received 07 Jun, 2020
Reviewer #2 agreed
On 06 Jun, 2020
Review #2 received
Received 06 Jun, 2020
Review #1 received
Received 28 May, 2020
Reviewer #1 agreed
On 27 May, 2020
Reviewers invited
Invitations sent on 26 May, 2020
Editor assigned
On 06 May, 2020
Submission checks complete
On 05 May, 2020
Editor invited
On 05 May, 2020
First submitted
On 04 May, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Maternal & Fetal Medicine
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at BMC Pregnancy and Childbirth.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Geum Joon Cho
Korea University College of Medicine
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Pregnancy and Childbirth.
Community comments: 1
Editorial decision: Accept
On 08 Nov, 2020
Editor assigned
On 07 Nov, 2020
Submission checks complete
On 07 Nov, 2020
Editor invited
On 07 Nov, 2020
Version 3
Posted 16 Sep, 2020
No comments provided
Editorial decision: Minor revision
On 08 Oct, 2020
Review #2 received
Received 26 Sep, 2020
Reviewer #2 agreed
On 24 Sep, 2020
Reviewers invited
Invitations sent on 23 Sep, 2020
Reviewer #1 agreed
On 23 Sep, 2020
Review #1 received
Received 23 Sep, 2020
Editor assigned
On 15 Sep, 2020
Submission checks complete
On 14 Sep, 2020
Editor invited
On 14 Sep, 2020
No comments provided
Editorial decision: Major revision
On 17 Aug, 2020
Review #2 received
Received 12 Aug, 2020
Reviewer #2 agreed
On 11 Aug, 2020
Editor assigned
On 09 Aug, 2020
Reviewers invited
Invitations sent on 09 Aug, 2020
Reviewer #1 agreed
On 09 Aug, 2020
Review #1 received
Received 09 Aug, 2020
Submission checks complete
On 08 Aug, 2020
Editor invited
On 08 Aug, 2020
No comments provided
Editorial decision: Major revision
On 06 Jul, 2020
Reviewer #3 agreed
On 07 Jun, 2020
Review #3 received
Received 07 Jun, 2020
Reviewer #2 agreed
On 06 Jun, 2020
Review #2 received
Received 06 Jun, 2020
Review #1 received
Received 28 May, 2020
Reviewer #1 agreed
On 27 May, 2020
Reviewers invited
Invitations sent on 26 May, 2020
Editor assigned
On 06 May, 2020
Submission checks complete
On 05 May, 2020
Editor invited
On 05 May, 2020
First submitted
On 04 May, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Maternal & Fetal Medicine
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Pregnancy and Childbirth.
Background: Our objective was to evaluate risks of adverse obstetric outcomes in pregnancies with myoma(s) or in pregnancies following myomectomy.
Methods: We analyzed the national health insurance database, which covers almost the entire Korean population, between 2004 and 2015. The risks of adverse pregnancy outcomes in pregnancies with myoma(s) or in pregnancies following myomectomy, compared to those in women without a diagnosed myoma, were analyzed in multivariate logistic regression analysis.
Results: During the study period, 38,402 women with diagnosed myoma(s), 9,890 women with a history of myomectomy, and 740,675 women without a diagnosed myoma gave birth. Women with a history of diagnosed myoma(s) and women with a history of myomectomy had significantly higher risks of cesarean section (aOR 1.13, 95% CI 1.1-1.16 and aOR 7.46, 95% CI 6.97-7.98, respectively) and placenta previa (aOR 1.41, 95% CI 1.29-1.54 and aOR 1.58, 95% CI 1.35-1.83, respectively), compared to women without a diagnosed myoma. And the risk of uterine rupture was significantly higher in women with previous myomectomy (aOR 12.78, 95% CI 6.5-25.13), compared to women without a diagnosed myoma, which was much increased (aOR 41.35, 95% CI 16.18-105.69) in nulliparous women. The incidence of uterine rupture was the highest at delivery within one year after myomectomy and decreased over time after myomectomy.
Conclusions: Women with a history of myomectomy had significantly higher risks of cesarean section and placenta previa compared to women without a diagnosed myoma.
Figure 1
Figure 2
This is a list of supplementary files associated with this preprint. Click to download.
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