In DM1 patients with bacterial keratitis 25.8% of eyes (16 eyes) had central localization of the disease, 54.8% of eyes (34 eyes) – paracentral one, in 19.4% of eyes (12 eyes) – peripheral one. Localization of bacterial keratitis in nondiabetic patients of the control group was central in 27.9% of eyes (12 eyes), paracentral – in 60.5% of eyes (26 eyes), peripheral – in 11.6% of eyes (5 eyes), was not statistically changed from the parameters of the DM1 patients (р>0.05).
The degree of pericorneal injection in DM1 patients with bacterial keratitis was found marked, moderate and mild in 48.4% (30 eyes), 37.1% (23 eyes) and 14.5% patients (9 eyes), respectively, versus 46.5% (20 eyes), 37.2% (16 eyes) and 16.3% nondiabetic patients (7 eyes) with bacterial keratitis of the control group, respectively, р>0.05.
Corneal ulcer defect size in DM1 patients with bacterial keratitis was found more than 5 mm, 2-5 mm, less than 2 mm in 27.4% (17 eyes), 35.5% (22 eyes) and 37.1% DM1 patients (23 eyes) with bacterial keratitis, respectively, versus 30.2% (13 eyes), 30.2% (13 eyes) and 39.6% (17 eyes) nondiabetic patients with bacterial keratitis of the control group, respectively, р>0.05.
In DM1 patients with bacterial keratitis the corneal ulcer defect depth was as deep as more than 2/3 of the corneal thickness in 8% (5 eyes), and as deep as 1/3-2/3 of the corneal thickness in 33.9% (21 eyes), and as deep as less than 1/3 of the corneal thickness in 58.1% (36 eyes). In nondiabetic patients with bacterial keratitis the corneal ulcer defect depth was as deep as more than 2/3 of the corneal thickness in 7% (3 eyes), and as deep as 1/3-2/3 of the corneal thickness in 27.9% (12 eyes), and as deep as less than 1/3 of the corneal thickness in 65.1% (28 eyes), was not statistically changed from the parameters of the DM1 patients (р>0.05).
The depth of corneal infiltration in DM1 patients was found diffuse, stromal and epithelial in 8.1% (5 eyes), 62.9% (39 eyes) and 29% patients (18 eyes), respectively, versus 7% (3 eyes), 60.5% (26 eyes) and 32.5% (14 eyes) nondiabetic patients with bacterial keratitis of the control group, respectively, р>0.05.
The depth of edema of the corneal tissue surrounding the ulcer in DM1 patients with bacterial keratitis was found diffuse, stromal and epithelial in 21% (13 eyes), 40.3% (25 eyes) and 38.7% patients (24 eyes), respectively, versus 20.9% (9 eyes), 39.5% (17 eyes) and 39.5% (17 eyes) nondiabetic patients with bacterial keratitis of the control group, respectively, р>0.05.
Compared to controls, DM1 patients with bacterial keratitis showed higher degree of inflammatory reaction in the anterior chamber of the eye, p<0.05 (tab 1). The degree of inflammatory reaction in the anterior chamber of the eye in DM1 patients with bacterial keratitis was found marked, moderate and mild in 17.7%, 27.4% and 48.4% patients, respectively, versus 7%, 25.6% and 51.2% nondiabetic patients with bacterial keratitis of the control group, respectively. In 6.5% and 16.2% of DM1 and nondiabetic patient with bacterial keratitis, respectively, inflammatory reaction in the anterior chamber of the eye was not found.
Compared to controls, DM1 patients with bacterial keratitis showed 28.8% lower mean corneal sensitivity threshold, p<0.05 (tab 2). Mean corneal sensitivity threshold in DM1 patients with bacterial keratitis was 164.8±29.4 ml/min, ranged from 119.8 to 235.6 ml/min. Mean corneal sensitivity threshold in nondiabetic patients with bacterial keratitis of the control group was 128±20.2 ml/min, ranged from 97.5 to 194.3 ml/min. The degree of decreasing of corneal sensitivity in DM1 patients with bacterial keratitis was higher than in nondiabetic patients of the control group, p<0.05. Severely, moderately and mildly decreased corneal sensitivity was found in 64.5%, 25.8% and 9.7% patients, respectively, in DM1 patients with bacterial keratitis, versus 7%, 39.5% and 53.5% nondiabetic patients with bacterial keratitis of the control group, respectively.