Currently, in pipe welding, it is nearly difficult for a human welder to weld the whole circumference of a pipe in a single uninterrupted pass using MIG welding causing inconsistencies in weld quality around the welded pipe. The aim of this study was to develop an automated-orbital pipe MIG welding system and to optimize welding parameters for enhancing ultimate tensile strength and Rockwell hardness of mild steel 1020 grade pipe. Three levels of variation were applied to the four input parameters that were chosen. Nine experiments were carried out using orthogonal array of L9. In this experimental investigation, the highest ultimate tensile strength (UTS) of 411.2 MPa and Rockwell hardness (RH) of 95 HRB were achieved at 110 A of current and 24 V of voltage, welding gun travel speed of 30 cm/min and 3 mm of arc length. For modeling the orbital pipe MIG welding process experimental input parameters and response results, a hybrid ANN-GA model was constructed. This model was used to forecast and optimize ultimate tensile strength and Rockwell hardness, as well as the process factors that go with it. The results indicated that the ANN-GA model could predict the output responses with a mean absolute error of 5.06e-05. During optimization, a 4-9-2 network trained with neural network of back propagation by Bayesian regularization approach was determined to have the greatest prediction capability, with maximum UTS and RH of 417.857 MPa and 96.5364 HRB, respectively. The predicted and confirmation test results were both found within the acceptable errors, according to a confirmation test conducted with the optimum parameters of the ANN-GA model.