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Research Article
Z. Khattari
Hashemite University
Corresponding Author
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This work is licensed under a CC BY 4.0 License. Read Full License
In this report, we have investigated the ability of the essential phospholipids and cholesterol found viral membrane of SARS-COV-2 to protect it from the radiation exposure. The applied mehod was Geometric Progression fitting procedure to obtained numerically the atomic number equivalenace (Zeq), for any photon energy absorption exposure (EBF) and absorption (EABF) buildup factors. The used energy range E∈ [0.015,15] MeV up to an ultimate penetration length of 40 mpf for viral membrane essential components phospholipids and cholesterol. Most importantly, the calculated Zeq values were found to vary with incident photon energy and phospholipids compositions. Also, both EBF and EABF were depend strongly on the photon energy and penetration depths. For phospholipids, these two factors almost coincide in the energy range studied while it slightly different for cholesterol. At energies < 150 keV, both buildup factors were found to to inversely proportional to Zeq values of the phospholipids and cholesterol. The buildup factors EABF and EBF were found to be larger for cholesterol than other phospholipids at nearly 60 keV for COVID-19 viral membrane. The above results have shown that the viral membrane can resist the radiation effects and prevent the coronavirus form being inactivated when exposed to γ- or X-rays radiotherapy treatment in medical trails except for a specific radiation energy depending on the mfp (i.e., 60 keV at 5 mfp).
Keywords
SARS-COV-2, COVID-19, Cholesterol, viral Phospholipids Radiation resistance, Buildup factors
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No competing interests reported.
This is a list of supplementary files associated with this preprint. Click to download.
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CURRENT STATUS: Under Revision
Version 1
Posted 11 Mar, 2021
No community comments so far
Editorial decision: Major revision
On 17 May, 2021
Reviews received
Received 15 May, 2021
Reviewers agreed
On 27 Apr, 2021
Reviews received
Received 26 Apr, 2021
Reviewers agreed
On 16 Apr, 2021
Reviewers invited
Invitations sent on 05 Apr, 2021
Editor assigned
On 05 Apr, 2021
Editor invited
On 09 Mar, 2021
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On 09 Mar, 2021
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On 25 Feb, 2021
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A new preprint design is coming!
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This preprint is under consideration at BMC Molecular and Cell Biology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Z. Khattari
Hashemite University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Revision
Version 1
Posted 11 Mar, 2021
No community comments so far
Editorial decision: Major revision
On 17 May, 2021
Reviews received
Received 15 May, 2021
Reviewers agreed
On 27 Apr, 2021
Reviews received
Received 26 Apr, 2021
Reviewers agreed
On 16 Apr, 2021
Reviewers invited
Invitations sent on 05 Apr, 2021
Editor assigned
On 05 Apr, 2021
Editor invited
On 09 Mar, 2021
Submission checks complete
On 09 Mar, 2021
First submitted
On 25 Feb, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
In this report, we have investigated the ability of the essential phospholipids and cholesterol found viral membrane of SARS-COV-2 to protect it from the radiation exposure. The applied mehod was Geometric Progression fitting procedure to obtained numerically the atomic number equivalenace (Zeq), for any photon energy absorption exposure (EBF) and absorption (EABF) buildup factors. The used energy range E∈ [0.015,15] MeV up to an ultimate penetration length of 40 mpf for viral membrane essential components phospholipids and cholesterol. Most importantly, the calculated Zeq values were found to vary with incident photon energy and phospholipids compositions. Also, both EBF and EABF were depend strongly on the photon energy and penetration depths. For phospholipids, these two factors almost coincide in the energy range studied while it slightly different for cholesterol. At energies < 150 keV, both buildup factors were found to to inversely proportional to Zeq values of the phospholipids and cholesterol. The buildup factors EABF and EBF were found to be larger for cholesterol than other phospholipids at nearly 60 keV for COVID-19 viral membrane. The above results have shown that the viral membrane can resist the radiation effects and prevent the coronavirus form being inactivated when exposed to γ- or X-rays radiotherapy treatment in medical trails except for a specific radiation energy depending on the mfp (i.e., 60 keV at 5 mfp).
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
No competing interests reported.
This is a list of supplementary files associated with this preprint. Click to download.
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