Among natural disasters, flood is increasingly recognized as a serious worldwide concern that causes the most damages in parts of agriculture, fishery, housing, and infrastructure, and strongly affects economic and social activities. Universally, there is a requirement to increase our conception of flood vulnerability and to outstretch methods and tools to assess it. Spatial analysis of flood vulnerability is part of non-structural measures to prevent and reduce flood destructive effects. Hence, the current study proposes a methodology for assessing the flood vulnerability in the area of watershed in a severely flooded area of Iran (i.e., Kashkan Watershed). First interdependency analysis among criteria (including population density, PD; livestock density, LD; percentage of farmers and ranchers, PFR; distance to industrial and mining areas, DTIM; distance to tourist and cultural heritage areas, DTTCH; land use; distance to residential areas, DTRe; distance to road, DTR; and distance to stream, DTS) was conducted using the decision-making trial and evaluation laboratory (DEMATEL) method. Hence, the cause and effect factors and their interaction levels in the whole network were investigated. Then, using the interdependency relationships among criteria, a network structure from flood vulnerability factors to determine their importance of factors was constructed and the analytical network process (ANP) was applied. Finally, with aim of overcome ambiguity, reduce uncertainty, and keep the data availability, an appropriate Fuzzy membership function was applied to each layer by analyzing the relationship of each layer with flood vulnerability. Importance analysis indicated that the variables of land use (0.197), DTS (0.181), PD (0.180), DTRe (0.140), and DTR (0.138) were the most important variables. The flood vulnerability map produced by the integrated method of DEMATEL-ANP-FUZZY showed that about 19.2% of the region has a high to very high flood vulnerability.