See the published version of this article at BMC Gastroenterology.
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Research article
Mohsen Karbalaei
Jiroft University of Medical Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0001-9899-2885
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Gastroenterology.
Background
Helicobacter pylori is accounted as the most etiologic agent for digestive disorders, in particular, the most important of them i.e. peptic ulcer and gastric cancer. In the recent years, association of vacA genotypes and gastrointestinal disorders has attracted a lot of attention. In present study, we assessed the correlation between vacA genotypes (s1, s2, m1, m2, s1m1, s1m2, s2m1 and s2m2) and development to peptic ulcer in Iranian population.
Methods
In our study, first, 23 original articles containing of information of 3328 patients were evaluated. Statistical analysis was done by Comprehensive Meta-Analysis version 2.0 software (Biostat, Englewood, NJ, USA). In this regards, we used from fixed-effects model for analysis of data with low heterogeneity, while for analysis of data with high heterogeneity (I2 statistic index > 25%, Cochrane Q statistic p value < 0.05), random-effects model was used.
Results
Abundance of each of s1, s2, m1, m2, s1m1, s1m2, s2m1, and s2m2 was estimated 36.24%, 28.32%, 42.90% 29.86%, 27.88%, 32.34%, 15.70%, and 25.94%, respectively. According to the results, the m1, s1, and s1m2 genotypes were among the most prevalent genotypes among the Iranian patients, whereas, s2m1 genotype had the lowest frequency.
Conclusions
Finally, we demonstrated that there is a significant relationship between infection of stomach with m1, s1m1, and s2m1 genotypes and development to peptic ulcer.
Keywords
Helicobacter pylori, Iran, peptic ulcer disease, vacA genotyp
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CURRENT STATUS: Published
Version 1
Posted 29 May, 2020
Published
On 14 Aug, 2020
No community comments so far
Editorial decision: Major revision
On 26 Jun, 2020
Review #2 received
Received 20 Jun, 2020
Review #1 received
Received 12 Jun, 2020
Reviewer #2 agreed
On 01 Jun, 2020
Reviewer #1 agreed
On 30 May, 2020
Reviewers invited
Invitations sent on 30 May, 2020
Editor assigned
On 10 May, 2020
Submission checks complete
On 09 May, 2020
Editor invited
On 09 May, 2020
First submitted
On 07 May, 2020
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Subject Areas
Gastroenterology & Hepatology
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This preprint is under consideration at BMC Gastroenterology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Mohsen Karbalaei
Jiroft University of Medical Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0001-9899-2885
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 1
Posted 29 May, 2020
Published
On 14 Aug, 2020
No community comments so far
Editorial decision: Major revision
On 26 Jun, 2020
Review #2 received
Received 20 Jun, 2020
Review #1 received
Received 12 Jun, 2020
Reviewer #2 agreed
On 01 Jun, 2020
Reviewer #1 agreed
On 30 May, 2020
Reviewers invited
Invitations sent on 30 May, 2020
Editor assigned
On 10 May, 2020
Submission checks complete
On 09 May, 2020
Editor invited
On 09 May, 2020
First submitted
On 07 May, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Gastroenterology & Hepatology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Gastroenterology.
Background
Helicobacter pylori is accounted as the most etiologic agent for digestive disorders, in particular, the most important of them i.e. peptic ulcer and gastric cancer. In the recent years, association of vacA genotypes and gastrointestinal disorders has attracted a lot of attention. In present study, we assessed the correlation between vacA genotypes (s1, s2, m1, m2, s1m1, s1m2, s2m1 and s2m2) and development to peptic ulcer in Iranian population.
Methods
In our study, first, 23 original articles containing of information of 3328 patients were evaluated. Statistical analysis was done by Comprehensive Meta-Analysis version 2.0 software (Biostat, Englewood, NJ, USA). In this regards, we used from fixed-effects model for analysis of data with low heterogeneity, while for analysis of data with high heterogeneity (I2 statistic index > 25%, Cochrane Q statistic p value < 0.05), random-effects model was used.
Results
Abundance of each of s1, s2, m1, m2, s1m1, s1m2, s2m1, and s2m2 was estimated 36.24%, 28.32%, 42.90% 29.86%, 27.88%, 32.34%, 15.70%, and 25.94%, respectively. According to the results, the m1, s1, and s1m2 genotypes were among the most prevalent genotypes among the Iranian patients, whereas, s2m1 genotype had the lowest frequency.
Conclusions
Finally, we demonstrated that there is a significant relationship between infection of stomach with m1, s1m1, and s2m1 genotypes and development to peptic ulcer.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
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